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Ppp2r2b Gene Detail
Summary
  • Symbol
    Ppp2r2b
  • Name
    protein phosphatase 2, regulatory subunit B, beta
  • Synonyms
    2900026H06Rik, 6330404L05Rik, E130009M08Rik, PP2A-PR55B, PR55-BETA, SCA12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920180
    NCBI Gene: 72930
  • Gene Overview
    MyGene.info: PPP2R2B
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr18:42637432-43059471 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      422040 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 22.75 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPP2R2B, protein phosphatase 2 regulatory subunit Bbeta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP2R2B, protein phosphatase 2 regulatory subunit Bbeta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55BETA, PR55-BETA, SCA12
  • Links
    NCBI Gene ID: 5521
    neXtProt AC: NX_Q00005
    UniProt: Q00005

  • Chr Location
    5q32; chr5:146589504-147081520 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human PPP2R2B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    172
  • Tissues
    25
  • cDNA Data
    25
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028098 VEGA Gene Model | MGI Sequence Detail 422040 C57BL/6J ±  kb
    transcript OTTMUST00000069607 VEGA | MGI Sequence Detail 2031 Not Applicable  
    polypeptide OTTMUSP00000035372 VEGA | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2916 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000013136 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
      (term hierarchy)
    • InterPro Domains
      IPR000009 Protein phosphatase 2A regulatory subunit PR55
      IPR018067 Protein phosphatase 2A regulatory subunit PR55, conserved site
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 28
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1917986, MGI:2442228
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:249035 Kannan M, et al., WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory