Ppp2r2b
Gene Detail

Symbol Name ID

Ppp2r2b protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform MGI:1920180

Synonyms

2900026H06Rik, 6330404L05Rik, E130009M08Rik, PP2A-PR55B, PR55-BETA, SCA12

Feature Type

protein coding gene

Genetic Map

Chromosome 18

22.75 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:42637432-43059471 bp, - strand From VEGA annotation of GRCm38   422040 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55833  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase 2A, subunit B55
Gene Tree: Ppp2r2b

Human homologs

Human Homolog		PPP2R2B, protein phosphatase 2, regulatory subunit B, beta
NCBI Gene ID		5521
neXtProt AC		NX_Q00005
Human Synonyms		B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55BETA, PR55-BETA, SCA12
Human Chr (Location)		5q32; chr5:145969067-146461033 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PPP2R2B

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	apoptotic process, mitochondrial fission, ...
Component	cytoplasm, cytoskeleton, ...
Function	protein complex binding, protein phosphatase type 2A regulator activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (172)    Tissues (25)    Images (24)
Theiler Stages: 23, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	156
Western blot	4
RT-PCR	8

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028098 (Evidence)
Ensembl Gene Model	ENSMUSG00000024500 (Evidence)
Entrez Gene	72930 (Evidence)
DFCI	TC1577620, TC1584763, TC1587312
DoTS	DT.101370879, DT.50315525, DT.91401956
Consensus CDS Project	CCDS29216.1, CCDS50268.1
International Mouse Knockout Project Status	Ppp2r2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028098	VEGA Gene Model | MGI Sequence Detail	422040	C57BL/6J
transcript	OTTMUST00000069607	VEGA | MGI Sequence Detail	2031	Not Applicable
polypeptide	OTTMUSP00000035372	VEGA | MGI Sequence Detail	446	Not Applicable

All sequences(50) RefSeq(5) UniProt(2)

Polymorphisms

SNPs(2059 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000009	Protein phosphatase 2A, regulatory subunit PR55
InterPro	IPR018067	Protein phosphatase 2A, regulatory subunit PR55, conserved site
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000013136	serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)

Other accession IDs

MGI:1917986, MGI:2442228