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Ppp2r2b
Gene Detail
Symbol

Name
ID
Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
MGI:1920180
Synonyms
2900026H06Rik, 6330404L05Rik, E130009M08Rik, PP2A-PR55B, PR55-BETA, SCA12
Feature Type
protein coding gene
Genetic Map
Chromosome 18
22.75 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:42637432-43059471 bp, - strand
From VEGA annotation of GRCm38

  422040 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55833  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase 2A, subunit B55
Gene Tree: Ppp2r2b

Human
homologs
Human Homolog PPP2R2B, protein phosphatase 2, regulatory subunit B, beta
NCBI Gene ID 5521
neXtProt AC  NX_Q00005
Human Synonyms  B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55BETA, PR55-BETA, SCA12
Human Chr (Location)  5q32; chr5:146589504-147081520 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PPP2R2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ppp2r2b interacts with 119 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, mitochondrial fission, ...
Component cytoplasm, cytoskeleton, ...
Function protein complex binding, protein phosphatase type 2A regulator activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (172)    Tissues (25)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 156
Western blot 4
RT-PCR 8
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(28) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000028098 (Evidence)
Ensembl Gene ModelENSMUSG00000024500 (Evidence)
Entrez Gene72930 (Evidence)
UniGene26134
DFCITC1587312, TC1577620, TC1584763
DoTSDT.101370879, DT.50315525, DT.91401956
Consensus CDS ProjectCCDS29216.1, CCDS50268.1
International Mouse Knockout Project StatusPpp2r2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028098 VEGA Gene Model | MGI Sequence Detail 422040 C57BL/6J ±  kb
transcript OTTMUST00000069607 VEGA | MGI Sequence Detail 2031 Not Applicable 
polypeptide OTTMUSP00000035372 VEGA | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(2926 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000009 Protein phosphatase 2A, regulatory subunit PR55
InterPro IPR018067 Protein phosphatase 2A, regulatory subunit PR55, conserved site
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000013136 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGI:1917986, MGI:2442228

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory