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Ppp2r2b
Gene Detail
Symbol

Name
ID
Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
MGI:1920180
Synonyms
2900026H06Rik, 6330404L05Rik, E130009M08Rik, PP2A-PR55B, PR55-BETA, SCA12
Feature Type
protein coding gene
Genetic Map
Chromosome 18
22.75 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:42637432-43059471 bp, - strand
From VEGA annotation of GRCm38

  422040 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55833  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPP2R2B
Protein SuperFamily: serine/threonine-protein phosphatase 2A, subunit B55
Gene Tree: Ppp2r2b

Human
homologs
PPP2R2B, protein phosphatase 2, regulatory subunit B, beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5521
neXtProt AC: NX_Q00005

Human Synonyms: B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55BETA, PR55-BETA, SCA12

Human Chr (Location): 5q32; chr5:146589504-147081520 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PPP2R2B

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ppp2r2b interacts with 119 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, mitochondrial fission, ...
Component cytoplasm, cytoskeleton, ...
Function protein complex binding, protein phosphatase type 2A regulator activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (172)    Tissues (25)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 156
Western blot 4
RT-PCR 8
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ppp2r2b ; ZFIN ppp2r2bb    NEW 
Molecular
reagents
All nucleic(30) cDNA(28) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000028098 (Evidence)
Ensembl Gene Model ENSMUSG00000024500 (Evidence)
Entrez Gene 72930 (Evidence)
UniGene 26134
DFCI TC1577620, TC1584763, TC1587312
DoTS DT.101370879, DT.50315525, DT.91401956
Consensus CDS Project CCDS29216.1, CCDS50268.1
International Mouse Phenotyping Consortium Status Ppp2r2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028098 VEGA Gene Model | MGI Sequence Detail 422040 C57BL/6J ±  kb
transcript OTTMUST00000069607 VEGA | MGI Sequence Detail 2031 Not Applicable 
polypeptide OTTMUSP00000035372 VEGA | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(2926 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000009 Protein phosphatase 2A, regulatory subunit PR55
InterPro IPR018067 Protein phosphatase 2A, regulatory subunit PR55, conserved site
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000013136 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGI:1917986, MGI:2442228

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory