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Hepacam Gene Detail
Summary
  • Symbol
    Hepacam
  • Name
    hepatocyte cell adhesion molecule
  • Synonyms
    2900042E01Rik, Glialcam
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920177
    NCBI Gene: 72927
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:37367606-37386572 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 20.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920177
protein coding gene Chr9:37367351-37386575 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034562
protein coding gene Chr9:35341808-35362321 (+)
A/J MGP_AJ_G0034541
protein coding gene Chr9:34406287-34425630 (+)
AKR/J MGP_AKRJ_G0034468
protein coding gene Chr9:35163261-35187086 (+)
BALB/cJ MGP_BALBcJ_G0034532
protein coding gene Chr9:34249036-34270986 (+)
C3H/HeJ MGP_C3HHeJ_G0034245
protein coding gene Chr9:35600455-35619616 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035054
protein coding gene Chr9:36463741-36485100 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031980
protein coding gene Chr9:33522089-33541397 (+)
CAST/EiJ MGP_CASTEiJ_G0033566
protein coding gene Chr9:35290583-35309387 (+)
CBA/J MGP_CBAJ_G0034218
protein coding gene Chr9:37733527-37755708 (+)
DBA/2J MGP_DBA2J_G0034376
protein coding gene Chr9:34461272-34482413 (+)
FVB/NJ MGP_FVBNJ_G0034317
protein coding gene Chr9:33706247-33725393 (+)
LP/J MGP_LPJ_G0034461
protein coding gene Chr9:35541510-35561390 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034363
protein coding gene Chr9:39343222-39363303 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035073
protein coding gene Chr9:35103899-35124071 (+)
PWK/PhJ MGP_PWKPhJ_G0033272
protein coding gene Chr9:34356261-34376585 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033106
protein coding gene Chr9:35306857-35326329 (+)
WSB/EiJ MGP_WSBEiJ_G0033682
protein coding gene Chr9:34911129-34930286 (+)



Homology
more
  • Human Ortholog
    HEPACAM, hepatic and glial cell adhesion molecule
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HEPACAM, hepatic and glial cell adhesion molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GlialCAM, HEPN1, MLC2A, MLC2B
  • Links
    NCBI Gene ID: 220296
    neXtProt AC: NX_Q14CZ8
    UniProt: Q14CZ8

  • Chr Location
    11q24.2; chr11:124919244-124936412 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with human HEPACAM associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 1 genetic background
    2 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display myelin vacuolization that progresses with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72927 NCBI Gene Model | MGI Sequence Detail 18967 C57BL/6J ±  kb
    transcript NM_175189 RefSeq | MGI Sequence Detail 3103 C57BL/6  
    polypeptide Q640R3 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 11
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:244698 Bugiani M, et al., Megalencephalic leukoencephalopathy with cysts: the Glialcam-null mouse model. Ann Clin Transl Neurol. 2017 Jul;4(7):450-465

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory