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March1 Gene Detail
Summary
  • Symbol
    March1
  • Name
    membrane-associated ring finger (C3HC4) 1
  • Synonyms
    2900024D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920175
    NCBI Gene: 72925
Location & Maps
more
  • Sequence Map
    Chr8:65617900-66471637 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      853738 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MARCH1, membrane associated ring-CH-type finger 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MARCH1, membrane associated ring-CH-type finger 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MARCH-I, RNF171
  • Links
    NCBI Gene ID: 55016
    neXtProt AC: NX_Q8TCQ1

  • Chr Location
    4q32.2; chr4:163524298-164383989 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving March1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit abnormal dendritic cell morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016640 VEGA Gene Model | MGI Sequence Detail 853738 C57BL/6J ±  kb
transcript OTTMUST00000040270 VEGA | MGI Sequence Detail 3288 Not Applicable  
polypeptide OTTMUSP00000017991 VEGA | MGI Sequence Detail 540 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6047 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010174 E3 ubiquitin-protein ligase MARCH1
  • EC
  • InterPro Domains
    IPR011016 Zinc finger, RING-CH-type
    IPR013083 Zinc finger, RING/FYVE/PHD-type
Molecular
Reagents
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  • All nucleic 22
    cDNA 22

    Microarray probesets 4
Other
Accession IDs
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MGI:2142827
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:226568 Cho KJ, et al., Ubiquitination by March-I prevents MHC class II recycling and promotes MHC class II turnover in antigen-presenting cells. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10449-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory