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March1
Gene Detail
 Symbol
Name
ID
March1
membrane-associated ring finger (C3HC4) 1
MGI:1920175
Synonyms 2900024D24Rik
Feature Type protein coding gene
Genetic Map
Chromosome 8
33.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:65617900-66471637 bp, + strand
From VEGA annotation of GRCm38

  853738 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113749  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: E3 ubiquitin-protein ligase MARCH
Gene Tree: March1

Human
homologs
Human Homolog MARCH1, membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
NCBI Gene ID 55016
neXtProt AC  NX_Q8TCQ1
Human Synonyms  MARCH-I, RNF171
Human Chr (Location)  4q32.2; chr4:163524298-164383255 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal dendritic cell morphology and physiology.
 
Interactions
March1 interacts with 380 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process antigen processing and presentation of peptide antigen via MHC class II, immune response, ...
Component cytoplasmic vesicle, early endosome membrane, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (122)    Tissues (12)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 122
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016640 (Evidence)
Ensembl Gene ModelENSMUSG00000036469 (Evidence)
Entrez Gene72925 (Evidence)
UniGene380457
DFCITC1582532, TC1594534, TC1609148, TC1627787, TC1636646
DoTSDT.55140802, DT.55281365, DT.94185377, DT.97389992, DT.99854253
NIA Mouse Gene IndexU072954
EC6.3.2.-
Consensus CDS ProjectCCDS22333.1, CCDS52560.1, CCDS52561.1
International Mouse Knockout Project StatusMarch1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016640 VEGA Gene Model | MGI Sequence Detail 853738 C57BL/6J ±  kb
transcript OTTMUST00000040270 VEGA | MGI Sequence Detail 3288 Not Applicable 
polypeptide OTTMUSP00000017991 VEGA | MGI Sequence Detail 540 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(18) UniProt(2)
Polymorphisms SNPs within 2kb(6117 from dbSNP Build 137)    SNPs within 2kb including multiple locations(6131)
Protein-related
information
ResourceIDDescription
InterPro IPR011016 Zinc finger, RING-CH-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000010174 E3 ubiquitin-protein ligase MARCH1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:201198 Oh J, et al., MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J Exp Med. 2013 Jun 3;210(6):1069-77
All references(37)
Other
accession IDs
MGI:2142827

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory