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March1 Gene Detail
Summary
  • Symbol
    March1
  • Name
    membrane-associated ring finger (C3HC4) 1
  • Synonyms
    2900024D24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920175
    NCBI Gene: 72925
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:65617922-66471637 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 33.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6047 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920175
protein coding gene Chr8:65617900-66471637 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033650
protein coding gene Chr8:65634060-66535567 (+)
A/J MGP_AJ_G0033632
protein coding gene Chr8:62894427-63793163 (+)
AKR/J MGP_AKRJ_G0033557
protein coding gene Chr8:64661264-65536027 (+)
BALB/cJ MGP_BALBcJ_G0033628
protein coding gene Chr8:63152722-64011445 (+)
C3H/HeJ MGP_C3HHeJ_G0033338
protein coding gene Chr8:65410146-66317958 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034145
protein coding gene Chr8:68098659-69029696 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031092
protein coding gene Chr8:58073376-58855067 (+)
CAST/EiJ MGP_CASTEiJ_G0032663
protein coding gene Chr8:64836295-65722535 (+)
CBA/J MGP_CBAJ_G0033316
protein coding gene Chr8:70603179-71600868 (+)
DBA/2J MGP_DBA2J_G0033470
protein coding gene Chr8:62685193-63544944 (+)
FVB/NJ MGP_FVBNJ_G0033411
protein coding gene Chr8:61894824-62740124 (+)
LP/J MGP_LPJ_G0033558
protein coding gene Chr8:65687913-66588049 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033455
protein coding gene Chr8:73168214-74231045 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034163
protein coding gene Chr8:64969184-65874708 (+)
PWK/PhJ MGP_PWKPhJ_G0032372
protein coding gene Chr8:61992217-62828441 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032208
protein coding gene Chr8:63891638-64790399 (+)
WSB/EiJ MGP_WSBEiJ_G0032780
protein coding gene Chr8:65331992-66248850 (+)



Homology
more
  • Human Ortholog
    MARCH1, membrane associated ring-CH-type finger 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MARCH1, membrane associated ring-CH-type finger 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MARCH-I, RNF171
  • Links
    NCBI Gene ID: 55016
    neXtProt AC: NX_Q8TCQ1
    UniProt: Q8TCQ1

  • Chr Location
    4q32.2-q32.3; chr4:163524298-164384050 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal dendritic cell morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72925 NCBI Gene Model | MGI Sequence Detail 853716 C57BL/6J ±  kb
transcript NM_001293784 RefSeq | MGI Sequence Detail 4444 C57BL/6  
polypeptide Q6NZQ8 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142827
References
more
  • Summaries
    All 47
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:266483 Borges TJ, et al., March1-dependent modulation of donor MHC II on CD103(+) dendritic cells mitigates alloimmunity. Nat Commun. 2018 Aug 28;9(1):3482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory