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Macrod2 Gene Detail
Summary
  • Symbol
    Macrod2
  • Name
    mono-ADP ribosylhydrolase 2
  • Synonyms
    1110033L15Rik, 2610107G07Rik, 2900006F19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920149
    NCBI Gene: 72899
  • Gene Overview
    MyGene.info: MACROD2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:140395356-142392966 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 69.20 cM, cytoband G3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16790 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920149
protein coding gene Chr2:140395309-142392966 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026571
protein coding gene Chr2:144328694-146378984 (+)
A/J MGP_AJ_G0026535
protein coding gene Chr2:138492790-140451088 (+)
AKR/J MGP_AKRJ_G0026509
protein coding gene Chr2:142455405-144495574 (+)
BALB/cJ MGP_BALBcJ_G0026547
protein coding gene Chr2:138897337-140895955 (+)
C3H/HeJ MGP_C3HHeJ_G0026290
protein coding gene Chr2:142978509-145044148 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026992
protein coding gene Chr2:148675128-150800202 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024368
protein coding gene Chr2:132805552-134741221 (+)
CAST/EiJ MGP_CASTEiJ_G0025751
protein coding gene Chr2:143290453-145394892 (+)
CBA/J MGP_CBAJ_G0026270
protein coding gene Chr2:154104491-156302829 (+)
DBA/2J MGP_DBA2J_G0026404
protein coding gene Chr2:137824293-139793797 (+)
FVB/NJ MGP_FVBNJ_G0026368
protein coding gene Chr2:136384301-138346463 (+)
LP/J MGP_LPJ_G0026508
protein coding gene Chr2:144470720-146564137 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026388
protein coding gene Chr2:158141115-160529999 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027047
protein coding gene Chr2:142433865-144518089 (+)
PWK/PhJ MGP_PWKPhJ_G0025487
protein coding gene Chr2:137407043-139429899 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025288
protein coding gene Chr2:141506405-143570800 (+)
WSB/EiJ MGP_WSBEiJ_G0025824
protein coding gene Chr2:143426431-145504732 (+)



Homology
more
  • Human Ortholog
    MACROD2, mono-ADP ribosylhydrolase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MACROD2, mono-ADP ribosylhydrolase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf133, C2orf133
  • Links
    NCBI Gene ID: 140733
    neXtProt AC: NX_A1Z1Q3
    UniProt: A1Z1Q3

  • Chr Location
    20p12.1; chr20:13995476-16053197 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, healthy and overtly normal and show no significant changes in irradiation-induced lethality, high fat diet-induced obesity, or response to glucose or insulin challenge relative to wild-type controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72899 NCBI Gene Model | MGI Sequence Detail 1997611 C57BL/6J ±  kb
    transcript NM_028387 RefSeq | MGI Sequence Detail 3552 C57BL/6  
    polypeptide Q3UYG8 UniProt | EBI | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Primer pair 1

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGI:1917687, MGI:1921002
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:271238 Lo Re O, et al., Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults. Front Genet. 2018;9:654

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory