Rtl8c Gene Detail

Summary

• Symbol
  Rtl8c
• Name
  retrotransposon Gag like 8C
• Synonyms
  2900027G03Rik, Cxx1c, Mar8.1, Mart8a

• Feature Type
  protein coding gene
• IDs
  MGI:1920115
  NCBI Gene: 72865
• Alliance
  genome feature page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  ChrX:52609999-52610399 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 29.82 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  89 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1920115	protein coding gene	ChrX:52609889-52611102 (+)
129S1/SvImJ	ENSMUSG00200037329	protein coding gene	ChrX:36511744-36512144 (+)
A/J	ENSMUSG00195016399	protein coding gene	ChrX:39664589-39664989 (-)
AKR/J	no annotation
BALB/cJ	ENSMUSG00180033236	protein coding gene	ChrX:37007408-37007808 (+)
C3H/HeJ	ENSMUSG00175039096	protein coding gene	ChrX:40041963-40042363 (+)
C57BL/6NJ	ENSMUSG00215047459	protein coding gene	ChrX:37010922-37011322 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033078	protein coding gene	ChrX:46201527-46201898 (-)
CAST/EiJ	ENSTCUG00005036515	protein coding gene	ChrX:38986900-38987300 (+)
CBA/J	ENSMUSG00210038484	protein coding gene	ChrX:37265483-37265883 (+)
DBA/2J	ENSMUSG00185032204	protein coding gene	ChrX:47969530-47969930 (+)
FVB/NJ	ENSMUSG00205028823	protein coding gene	ChrX:35597759-35598159 (+)
JF1/MsJ	ENSUMUG00000021480	protein coding gene	ChrX:67000943-67001343 (+)
LP/J	ENSMUSG00230027817	protein coding gene	ChrX:54516773-54517173 (+)
NOD/ShiLtJ	ENSMUSG00190034351	protein coding gene	ChrX:36375066-36375466 (+)
NZO/HlLtJ	ENSMUSG00225042666	protein coding gene	ChrX:59693901-59694301 (+)
PWK/PhJ	ENSLUMG00010040401	protein coding gene	ChrX:36685386-36685786 (+)
SPRET/EiJ	ENSMSPG00010021522	protein coding gene	ChrX:38399654-38400054 (+)
WSB/EiJ	ENSIUOG00005046676	protein coding gene	ChrX:37514500-37514900 (+)

Homology

• Human Ortholog
  RTL8A, retrotransposon Gag like 8A

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  RTL8A, retrotransposon Gag like 8A
  
• Synonyms
  CXX1b, FAM127B, MAR8A, SIRH6
• Links
  HGNC:24514

  NCBI Gene ID: 26071

  UniProt: Q9BWD3

  
  
• Chr Location
  Xq26.3; chrX:135050932-135052196 (-)  GRCh38

---

• Human Ortholog
  RTL8B, retrotransposon Gag like 8B
  
• Synonyms
  CXX1c, FAM127C, MAR8B, SIRH4
• Links
  HGNC:33156

  NCBI Gene ID: 441518

  UniProt: Q17RB0

  
  
• Chr Location
  Xq26.3; chrX:135020513-135022542 (-)  GRCh38

---

• Human Ortholog
  RTL8C, retrotransposon Gag like 8C
  
• Synonyms
  CXX1, FAM127A, Mar8, MAR8C, Mart8, MART8C, SIRH5
• Links
  HGNC:2569

  NCBI Gene ID: 8933

  UniProt: A6ZKI3

  
  
• Chr Location
  Xq26.3; chrX:135032355-135033546 (+)  GRCh38

---

• MGI Vertebrate Homology
  Rtl8c stringent orthology
  3 human;1 mouse
  
• HCOP
  vertebrate homology predictions: RTL8A, RTL8B, RTL8C
• Gene Tree
  Rtl8c
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Targeted
  1
• Incidental Mutations
  APF
• Find Mice (IMSR)
  1 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  633
• Tissues
  7
• cDNA Data
  42
• Literature Summary
  2

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  32
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS40975.1

• Ensembl
  ENSMUSG00000051851 (Evidence)
• NCBI Gene
  72865

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000051851	Ensembl Gene Model | MGI Sequence Detail	401	C57BL/6J
transcript	ENSMUST00000063384	Ensembl | MGI Sequence Detail	401	Not Applicable
polypeptide	ENSMUSP00000069901	Ensembl | MGI Sequence Detail	112	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• InterPro Domains
  IPR032549 RTL1/3-8/LDOC, capsid-like domain

Molecular
Reagents

• All nucleic 42

  cDNA 42

  
  

  Microarray probesets 2

Other
Accession IDs

MGI:5906155

References

• Summaries
  All 22

  Developmental Gene Expression 2

  Phenotypes 1
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:336757 Mohan HM, et al., RTL8 promotes nuclear localization of UBQLN2 to subnuclear compartments associated with protein quality control. Cell Mol Life Sci. 2022 Mar 5;79(3):176

TSS for Rtl8c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160967	ChrX:52609859-52609883 (+)	-128 bp
Tssr160968	ChrX:52609885-52609921 (+)	-96 bp
Tssr160969	ChrX:52609926-52609945 (+)	-63 bp
Tssr160970	ChrX:52609954-52609982 (+)	-31 bp