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Crtac1 Gene Detail
Summary
  • Symbol
    Crtac1
  • Name
    cartilage acidic protein 1
  • Synonyms
    2810454P21Rik, Crtac1B, Lotus
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920082
    NCBI Gene: 72832
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:42283037-42431783 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 36.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1336 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920082
protein coding gene Chr19:42283036-42431822 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025145
protein coding gene Chr19:41616594-41769517 (-)
A/J MGP_AJ_G0025122
protein coding gene Chr19:39612088-39763855 (-)
AKR/J MGP_AKRJ_G0025090
protein coding gene Chr19:40901211-41051107 (-)
BALB/cJ MGP_BALBcJ_G0025116
protein coding gene Chr19:39676607-39823635 (-)
C3H/HeJ MGP_C3HHeJ_G0024876
protein coding gene Chr19:41059952-41204621 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025559
protein coding gene Chr19:42685229-42835258 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022973
protein coding gene Chr19:38966609-39112252 (-)
CAST/EiJ MGP_CASTEiJ_G0024341
protein coding gene Chr19:40741358-40890993 (-)
CBA/J MGP_CBAJ_G0024856
protein coding gene Chr19:44766699-44921333 (-)
DBA/2J MGP_DBA2J_G0024988
protein coding gene Chr19:39459580-39604397 (-)
FVB/NJ MGP_FVBNJ_G0024949
protein coding gene Chr19:39235630-39382200 (-)
LP/J MGP_LPJ_G0025074
protein coding gene Chr19:41604165-41755633 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024980
protein coding gene Chr19:44386638-44538086 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025617
protein coding gene Chr19:40954854-41102162 (-)
PWK/PhJ MGP_PWKPhJ_G0024090
protein coding gene Chr19:39353951-39498986 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023894
protein coding gene Chr19:39702542-39849242 (-)
WSB/EiJ MGP_WSBEiJ_G0024411
protein coding gene Chr19:41109599-41256088 (-)



Homology
more
  • Human Ortholog
    CRTAC1, cartilage acidic protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRTAC1, cartilage acidic protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ASPIC, ASPIC1, CEP68, CEP-68, LOTUS
  • Links
    NCBI Gene ID: 55118
    neXtProt AC: NX_Q9NQ79
    UniProt: Q9NQ79

  • Chr Location
    10q24.2; chr10:97854711-98030828 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 23070
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CRTAC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormalities in lateral olfactory tract morphology and axon fasciculation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042401 Ensembl Gene Model | MGI Sequence Detail 148747 C57BL/6J ±  kb
    transcript ENSMUST00000048630 Ensembl | MGI Sequence Detail 2616 Not Applicable  
    polypeptide ENSMUSP00000044858 Ensembl | MGI Sequence Detail 646 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147688
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:266049 Kawakami Y, et al., The soluble form of LOTUS inhibits Nogo receptor type 1-mediated signaling induced by B lymphocyte stimulator and chondroitin sulfate proteoglycans. Neurosci Lett. 2018 Sep 14;683:61-68

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory