About   Help   FAQ
Crtac1 Gene Detail
Summary
  • Symbol
    Crtac1
  • Name
    cartilage acidic protein 1
  • Synonyms
    2810454P21Rik, Crtac1B, Lotus
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920082
    NCBI Gene: 72832
Location & Maps
more
  • Sequence Map
    Chr19:42283037-42431783 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      148747 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 36.07 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CRTAC1, cartilage acidic protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CRTAC1, cartilage acidic protein 1
    Orthology source: HomoloGene
  • Synonyms
    ASPIC, ASPIC1, CEP-68
  • Links
    NCBI Gene ID: 55118
    neXtProt AC: NX_Q9NQ79

  • Chr Location
    10q22; chr10:97854711-98030828 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    13
  • Targeted
    1
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit abnormalities in lateral olfactory tract morphology and axon fasciculation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042401 Ensembl Gene Model | MGI Sequence Detail 148747 C57BL/6J ±  kb
transcript ENSMUST00000048630 Ensembl | MGI Sequence Detail 2616 Not Applicable  
polypeptide ENSMUSP00000044858 Ensembl | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1336 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005898 cartilage acidic protein 1
  • InterPro Domains
    IPR011519 ASPIC/UnbV
    IPR027039 Cartilage acidic protein 1
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147688
References
more
  • Summaries
    All 30
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:214096 Kurihara Y, et al., LOTUS suppresses axon growth inhibition by blocking interaction between Nogo receptor-1 and all four types of its ligand. Mol Cell Neurosci. 2014 Jul;61:211-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory