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Fance Gene Detail
Summary
  • Symbol
    Fance
  • Name
    Fanconi anemia, complementation group E
  • Synonyms
    2810451D06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920025
    NCBI Gene: 72775
  • Gene Overview
    MyGene.info: FANCE
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28313530-28326568 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 14.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920025
protein coding gene Chr17:28313530-28326574 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023437
protein coding gene Chr17:27700508-27715082 (+)
A/J MGP_AJ_G0023395
protein coding gene Chr17:26795080-26808091 (+)
AKR/J MGP_AKRJ_G0023360
protein coding gene Chr17:26991493-27004493 (+)
BALB/cJ MGP_BALBcJ_G0023400
protein coding gene Chr17:27061991-27075019 (+)
C3H/HeJ MGP_C3HHeJ_G0023161
protein coding gene Chr17:27372270-27386467 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023842
protein coding gene Chr17:28819714-28833559 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021317
protein coding gene Chr17:24167269-24180556 (+)
CAST/EiJ MGP_CASTEiJ_G0022662
protein coding gene Chr17:27349582-27365805 (+)
CBA/J MGP_CBAJ_G0023135
protein coding gene Chr17:29842127-29859493 (+)
DBA/2J MGP_DBA2J_G0023266
protein coding gene Chr17:26348927-26362213 (+)
FVB/NJ MGP_FVBNJ_G0023236
protein coding gene Chr17:26154880-26169736 (+)
LP/J MGP_LPJ_G0023344
protein coding gene Chr17:27953301-27967904 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023254
protein coding gene Chr17:29276423-29295501 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023884
protein coding gene Chr17:27409598-27424085 (+)
PWK/PhJ MGP_PWKPhJ_G0022412
protein coding gene Chr17:25157111-25170392 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022230
protein coding gene Chr17:25419503-25432249 (+)
WSB/EiJ MGP_WSBEiJ_G0022724
protein coding gene Chr17:27409024-27423731 (+)



Homology
more
  • Human Ortholog
    FANCE, FA complementation group E
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FANCE, FA complementation group E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FACE, FAE
  • Links
    NCBI Gene ID: 2178
    neXtProt AC: NX_Q9HB96
    UniProt: Q9HB96

  • Chr Location
    6p21.31; chr6:35452339-35467106 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11066
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FANCE
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human FANCE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007570 Ensembl Gene Model | MGI Sequence Detail 13039 C57BL/6J ±  kb
transcript ENSMUST00000114803 Ensembl | MGI Sequence Detail 2025 Not Applicable  
polypeptide ENSMUSP00000110451 Ensembl | MGI Sequence Detail 526 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    10 Sequences
  • InterPro Domains
    IPR021025 Fanconi Anaemia group E protein, C-terminal
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146848, MGI:2147054
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:251511 Fu C, et al., Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice. PLoS One. 2016;11(8):e0159800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory