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Neil1
Gene Detail
 Symbol
Name
ID
Neil1
nei endonuclease VIII-like 1 (E. coli)
MGI:1920024
Synonyms 2810450N13Rik
Feature Type protein coding gene
Genetic Map
Chromosome 9
30.89 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:57143256-57147034 bp, - strand
From NCBI annotation of GRCm38

  3779 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Neil1

Human
homologs
Human Homolog NEIL1, nei endonuclease VIII-like 1 (E. coli)
NCBI Gene ID 79661
neXtProt AC  NX_Q96FI4
Human Synonyms  FPG1, hFPG1, NEI1
Human Chr (Location)  15q24.2; chr15:75346990-75355251 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice develop severe obesity, dyslipidemia, fatty liver disease and tend to show hyperinsulinemia and increased mtDNA damage and deletions. Sporadic phenotypes include reduced subcutaneous fat, skin ulcers, joint inflammation, infertility, and tumors. Male heterozygotes become obese.
 
Human Diseases Modeled Using Mouse Neil1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process base-excision repair, cellular response to DNA damage stimulus, ...
Component chromosome, cytoplasm, ...
Function catalytic activity, damaged DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (4)   
Theiler Stages: 10, 18, 23, 25
Assay TypeResults
RT-PCR 4
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032298 (Evidence)
Entrez Gene72774 (Evidence)
DFCITC1581946, TC1594624, TC1596083
DoTSDT.101328076, DT.101362419, DT.50315989
NIA Mouse Gene IndexU030915
EC3.2.2.-, 4.2.99.18
Consensus CDS ProjectCCDS23217.1
International Mouse Knockout Project StatusNeil1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72774 NCBI Gene Model | MGI Sequence Detail 3779 C57BL/6J ±  kb
transcript NM_028347 RefSeq | MGI Sequence Detail 1170 C57BL/6 
polypeptide Q8K4Q6 UniProt | EBI | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012319 DNA glycosylase/AP lyase, catalytic domain
InterPro IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding
InterPro IPR015371 Endonuclease VIII-like 1, DNA binding
InterPro IPR010979 Ribosomal protein S13-like, H2TH
Protein Ontology PR:000011122 endonuclease 8-like 1
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190031 Canugovi C, et al., Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14948-53
All references(41)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory