Neil1
Gene Detail

Symbol Name ID

Neil1 nei endonuclease VIII-like 1 (E. coli) MGI:1920024

Synonyms

2810450N13Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 9

30.89 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:57143256-57147034 bp, - strand From NCBI annotation of GRCm38   3779 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Neil1 ± 2 cM)

Gene Tree: Neil1

Human ortholog

NEIL1 nei endonuclease VIII-like 1 (E. coli) NCBI Gene ID 79661
Human Synonyms: FPG1, hFPG1, NEI1
Human Chr15:75639331-75647588 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice develop severe obesity, dyslipidemia, fatty liver disease and tend to show hyperinsulinemia and increased mtDNA damage and deletions. Sporadic phenotypes include reduced subcutaneous fat, skin ulcers, joint inflammation, infertility, and tumors. Male heterozygotes become obese.

 
Human Diseases Modeled Using Mouse Neil1 (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	base-excision repair, DNA repair, ...
Component	chromosome, cytoplasm, ...
Function	catalytic activity, damaged DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (4)   
Theiler Stages: 10, 18, 23, 25

Assay Type	Results
RT-PCR	4

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032298 (Evidence)
Entrez Gene	72774 (Evidence)
DFCI	TC1581946, TC1594624, TC1596083
DoTS	DT.101328076, DT.101362419, DT.50315989
NIA Mouse Gene Index	U030915
EC	3.2.2.-, 4.2.99.18
Consensus CDS Project	CCDS23217.1
International Mouse Knockout Project Status	Neil1

Sequences

Length	Strain/Species
genomic	72774	NCBI Gene Model | MGI Sequence Detail	3779	C57BL/6J
transcript	NM_028347	RefSeq | MGI Sequence Detail	1170	C57BL/6
polypeptide	Q8K4Q6	UniProt | EBI | MGI Sequence Detail	389	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012319	DNA glycosylase/AP lyase, catalytic domain
InterPro	IPR015886	DNA glycosylase/AP lyase, H2TH DNA-binding
InterPro	IPR015371	Endonuclease VIII-like 1, DNA binding
InterPro	IPR010979	Ribosomal protein S13-like, H2TH
Protein Ontology	PR:000011122	endonuclease 8-like 1

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:190031 Canugovi C, et al., Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14948-53
All references(41)