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Tmem135 Gene Detail
Summary
  • Symbol
    Tmem135
  • Name
    transmembrane protein 135
  • Synonyms
    2810439K08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1920009
    NCBI Gene: 72759
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:89139714-89404222 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 49.32 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1561 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1920009
protein coding gene Chr7:89139714-89404274 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032494
protein coding gene Chr7:91544013-91814195 (-)
A/J MGP_AJ_G0032468
protein coding gene Chr7:89365002-89621257 (-)
AKR/J MGP_AKRJ_G0032404
protein coding gene Chr7:91437601-91697651 (-)
BALB/cJ MGP_BALBcJ_G0032479
protein coding gene Chr7:89005622-89266992 (-)
C3H/HeJ MGP_C3HHeJ_G0032194
protein coding gene Chr7:91831642-92102601 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032977
protein coding gene Chr7:95095363-95369484 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029972
protein coding gene Chr7:92288741-92537755 (-)
CAST/EiJ MGP_CASTEiJ_G0031521
protein coding gene Chr7:83268870-83537814 (-)
CBA/J MGP_CBAJ_G0032161
protein coding gene Chr7:98279355-98557718 (-)
DBA/2J MGP_DBA2J_G0032313
protein coding gene Chr7:87790105-88051473 (-)
FVB/NJ MGP_FVBNJ_G0032269
protein coding gene Chr7:87665405-87924547 (-)
LP/J MGP_LPJ_G0032402
protein coding gene Chr7:92785201-93049403 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032303
protein coding gene Chr7:99327433-99611466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032999
protein coding gene Chr7:90715296-90994198 (-)
PWK/PhJ MGP_PWKPhJ_G0031239
protein coding gene Chr7:80810933-81067233 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031082
protein coding gene Chr7:78036397-78310897 (-)
WSB/EiJ MGP_WSBEiJ_G0031638
protein coding gene Chr7:91346609-91607104 (-)



Homology
more
  • Human Ortholog
    TMEM135, transmembrane protein 135
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMEM135, transmembrane protein 135
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PMP52
  • Links
    NCBI Gene ID: 65084
    neXtProt AC: NX_Q86UB9
    UniProt: Q86UB9

  • Chr Location
    11q14.2; chr11:87037844-87328834 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039428 Ensembl Gene Model | MGI Sequence Detail 264509 C57BL/6J ±  kb
transcript ENSMUST00000041968 Ensembl | MGI Sequence Detail 3700 Not Applicable  
polypeptide ENSMUSP00000042783 Ensembl | MGI Sequence Detail 458 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 83
    cDNA 83

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142228
References
more
  • Summaries
    All 57
    Gene Ontology 5
    Phenotypes 31
  • Earliest
    J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
  • Latest
    J:237184 Lee WH, et al., Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. Elife. 2016 Nov 15;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory