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Tmx1 Gene Detail
Summary
  • Symbol
    Tmx1
  • Name
    thioredoxin-related transmembrane protein 1
  • Synonyms
    2810425A04Rik, Txndc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919986
    NCBI Gene: 72736
  • Gene Overview
    MyGene.info: TMX1
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:70453154-70467624 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 29.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919986
 protein coding gene Chr12:70453095-70468040 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019810
 protein coding gene Chr12:70201897-70217303 (+)
A/J MGP_AJ_G0019768
 protein coding gene Chr12:67582537-67597959 (+)
AKR/J MGP_AKRJ_G0019744
 protein coding gene Chr12:69596641-69611499 (+)
BALB/cJ MGP_BALBcJ_G0019748
 protein coding gene Chr12:68050819-68065678 (+)
C3H/HeJ MGP_C3HHeJ_G0019554
 protein coding gene Chr12:70099019-70114030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020200
 protein coding gene Chr12:72430285-72447418 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017820
 protein coding gene Chr12:65113162-65127499 (+)
CAST/EiJ MGP_CASTEiJ_G0019105
 protein coding gene Chr12:64839122-64854306 (+)
CBA/J MGP_CBAJ_G0019523
 protein coding gene Chr12:75133215-75150956 (+)
DBA/2J MGP_DBA2J_G0019639
 protein coding gene Chr12:67504243-67519773 (+)
FVB/NJ MGP_FVBNJ_G0019626
 protein coding gene Chr12:66397624-66413067 (+)
LP/J MGP_LPJ_G0019711
 protein coding gene Chr12:70195366-70211932 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019665
 protein coding gene Chr12:78403253-78419051 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020235
 protein coding gene Chr12:69106561-69121430 (+)
PWK/PhJ MGP_PWKPhJ_G0018870
 protein coding gene Chr12:61776581-61792976 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018665
 protein coding gene Chr12:63481239-63496706 (+)
WSB/EiJ MGP_WSBEiJ_G0019156
 protein coding gene Chr12:69724069-69739149 (+)



Homology
more
  • Human Ortholog
    TMX1, thioredoxin related transmembrane protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TMX1, thioredoxin related transmembrane protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PDIA11, TMX, TXNDC, TXNDC1
  • Links
    NCBI Gene ID: 81542
    neXtProt AC: NX_Q9H3N1
    UniProt: Q9H3N1

  • Chr Location
    14q22.1; chr14:51240168-51257655 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 12482
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TMX1
  • Gene Tree
    Tmx1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
No notable phenotype was detected in a high-throughput screen of homozygous mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    11
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72736 NCBI Gene Model | MGI Sequence Detail 14471 C57BL/6J ±  kb
transcript NM_028339 RefSeq | MGI Sequence Detail 2418 Not Specified  
polypeptide Q8VBT0 UniProt | EBI | MGI Sequence Detail 278 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144841
References
more
  • Summaries
    All 33
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:273087 Zhao Z, et al., The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses. Blood. 2019 Jan 17;133(3):246-251
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/08/2019
MGI 6.14 		The Jackson Laboratory