Tmx1 MGI Mouse Gene Detail - MGI:1919986 - thioredoxin-related transmembrane protein 1

Symbol

Tmx1
Name

thioredoxin-related transmembrane protein 1
Synonyms

2810425A04Rik, Txndc1

Feature Type

protein coding gene
IDs

MGI:1919986
NCBI Gene: 72736
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr12:70499928-70514398 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 29.13 cM
Mapping Data

2 experiments

SNPs within 2kb

512 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919986	protein coding gene	Chr12:70499869-70514814 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019810	protein coding gene	Chr12:70201897-70217303 (+)
A/J	MGP_AJ_G0019768	protein coding gene	Chr12:67582537-67597959 (+)
AKR/J	MGP_AKRJ_G0019744	protein coding gene	Chr12:69596641-69611499 (+)
BALB/cJ	MGP_BALBcJ_G0019748	protein coding gene	Chr12:68050819-68065678 (+)
C3H/HeJ	MGP_C3HHeJ_G0019554	protein coding gene	Chr12:70099019-70114030 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020200	protein coding gene	Chr12:72430285-72447418 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017820	protein coding gene	Chr12:65113162-65127499 (+)
CAST/EiJ	MGP_CASTEiJ_G0019105	protein coding gene	Chr12:64839122-64854306 (+)
CBA/J	MGP_CBAJ_G0019523	protein coding gene	Chr12:75133215-75150956 (+)
DBA/2J	MGP_DBA2J_G0019639	protein coding gene	Chr12:67504243-67519773 (+)
FVB/NJ	MGP_FVBNJ_G0019626	protein coding gene	Chr12:66397624-66413067 (+)
LP/J	MGP_LPJ_G0019711	protein coding gene	Chr12:70195366-70211932 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019665	protein coding gene	Chr12:78403253-78419051 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020235	protein coding gene	Chr12:69106561-69121430 (+)
PWK/PhJ	MGP_PWKPhJ_G0018870	protein coding gene	Chr12:61776581-61792976 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018665	protein coding gene	Chr12:63481239-63496706 (+)
WSB/EiJ	MGP_WSBEiJ_G0019156	protein coding gene	Chr12:69724069-69739149 (+)

Human Ortholog

TMX1, thioredoxin related transmembrane protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMX1, thioredoxin related transmembrane protein 1
Synonyms

PDIA11, TMX, TXNDC, TXNDC1
Links

HGNC:15487

NCBI Gene ID: 81542

UniProt: Q9H3N1
Chr Location

14q22.1; chr14:51240162-51257655 (+) GRCh38

MGI Vertebrate Homology

Tmx1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMX1
Gene Tree

Tmx1

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

4
Genomic Mutations

1 involving Tmx1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available

No notable phenotype was detected in a high-throughput screen of homozygous mice.

less

All GO Annotations

43
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmx1

less

All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS25958.1

Ensembl

ENSMUSG00000021072 (Evidence)
NCBI Gene

72736

			Length	Strain/Species	Flank
genomic	72736	NCBI Gene Model \| MGI Sequence Detail	14471	C57BL/6J	± kb
transcript	NM_028339	RefSeq \| MGI Sequence Detail	2418	Not Specified
polypeptide	Q8VBT0	UniProt \| EBI \| MGI Sequence Detail	278	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000016855 thioredoxin-related transmembrane protein 1

(term hierarchy)
EC

5.3.4.1
InterPro Domains

IPR017937 Thioredoxin, conserved site

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily

IPR052454 Thioredoxin-related transmembrane domain-containing protein
GlyGen

Q8VBT0 1 site, 1 O-linked glycan (1 site)

less

All nucleic 11

cDNA 11

Microarray probesets 4

less

MGI:2144841

Summaries

All 41

Gene Ontology 9

Phenotypes 12
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:362983 Chen F, et al., Differential transport pathways of saturated and unsaturated fatty acid esters in male mouse hepatocytes. Nat Commun. 2025 Feb 4;16(1):1344

TSS for Tmx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113679	Chr12:70499848-70499854 (+)	-77 bp
Tssr113680	Chr12:70499870-70499881 (+)	-52 bp
Tssr113681	Chr12:70499895-70499939 (+)	-11 bp
Tssr113682	Chr12:70502165-70502180 (+)	2,245 bp
Tssr113683	Chr12:70502480-70502484 (+)	2,554 bp
Tssr113684	Chr12:70506598-70506609 (+)	6,676 bp
Tssr113685	Chr12:70506640-70506647 (+)	6,716 bp
Tssr113686	Chr12:70507296-70507321 (+)	7,381 bp
Tssr113687	Chr12:70512889-70512909 (+)	12,971 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24