Tmx1 Gene Detail

Summary

• Symbol
  Tmx1
• Name
  thioredoxin-related transmembrane protein 1
• Synonyms
  2810425A04Rik, Txndc1

• Feature Type
  protein coding gene
• IDs
  MGI:1919986
  NCBI Gene: 72736
• Gene Overview
  MyGene.info: TMX1

Location & Maps

• Sequence Map
  Chr12:70453095-70468040 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    14946 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 29.13 cM
• Mapping Data
  2 experiments

Homology

• Human Ortholog
  TMX1, thioredoxin related transmembrane protein 1

• Vertebrate Orthologs
  9

• Human Ortholog
  TMX1, thioredoxin related transmembrane protein 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  PDIA11, TMX, TXNDC, TXNDC1
• Links
  HGNC:15487

  NCBI Gene ID: 81542

  neXtProt AC: NX_Q9H3N1

  
  
• Chr Location
  14q22.1; chr14:51240168-51257655 (+)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 12482
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: TMX1
• Gene Tree
  Tmx1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Gene trapped
  1
• Targeted
  3
• Genomic Mutations
  1 involving Tmx1
• Incidental Mutations
  Mutagenetix , APF

Gene Ontology
(GO)
Classifications

• All GO Annotations
  14
• GO References
  4

• External Resources
  FuncBase

Expression

• cDNA Data
  10

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  Xenbase tmx1

Interactions

• Tmx1 interacts with 258 markers (Mir1a-1, Mir1a-2, Mir9-1, ...) View All

Sequences &
Gene Models

• All Sequences
  31
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS25958.1

• VEGA
  OTTMUSG00000034933 (Evidence)
• Ensembl
  ENSMUSG00000021072 (Evidence)
• NCBI Gene
  72736

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000034933	VEGA Gene Model | MGI Sequence Detail	14946	C57BL/6J
transcript	OTTMUST00000088824	VEGA | MGI Sequence Detail	2795	Not Applicable
polypeptide	OTTMUSP00000048463	VEGA | MGI Sequence Detail	278	Not Applicable

Polymorphisms

• SNPs within 2kb
  142 from dbSNP Build 142

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000016855 thioredoxin-related transmembrane protein 1
• InterPro Domains
  IPR017937 Thioredoxin, conserved site
  IPR013766 Thioredoxin domain
  IPR012336 Thioredoxin-like fold

Molecular
Reagents

• All nucleic 10

  cDNA 10

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:2144841

References

• Summaries
  All 30

  Gene Ontology 4

  Phenotypes 7
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42