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Zcchc17 Gene Detail
Summary
  • Symbol
    Zcchc17
  • Name
    zinc finger, CCHC domain containing 17
  • Synonyms
    2810055E05Rik, HSPC251, Ps1d
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919955
    NCBI Gene: 619605
  • Gene Overview
    MyGene.info: ZCCHC17
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:130315902-130359963 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.43 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919955
protein coding gene Chr4:130315383-130359963 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028850
protein coding gene Chr4:132321918-132365892 (-)
A/J MGP_AJ_G0028809
protein coding gene Chr4:127008574-127053662 (-)
AKR/J MGP_AKRJ_G0028762
protein coding gene Chr4:130569531-130616809 (-)
BALB/cJ MGP_BALBcJ_G0028832
protein coding gene Chr4:127621525-127666450 (-)
C3H/HeJ MGP_C3HHeJ_G0028546
protein coding gene Chr4:130627729-130673027 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029274
protein coding gene Chr4:137267487-137317424 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026546
protein coding gene Chr4:120124754-120168441 (-)
CAST/EiJ MGP_CASTEiJ_G0027979
protein coding gene Chr4:128842235-128887824 (-)
CBA/J MGP_CBAJ_G0028512
protein coding gene Chr4:140773094-140820325 (-)
DBA/2J MGP_DBA2J_G0028661
protein coding gene Chr4:127442773-127488181 (-)
FVB/NJ MGP_FVBNJ_G0028628
protein coding gene Chr4:126235298-126280620 (-)
LP/J MGP_LPJ_G0028762
protein coding gene Chr4:132648984-132693661 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028654
protein coding gene Chr4:145470066-145517007 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029312
protein coding gene Chr4:130938320-130988954 (-)
PWK/PhJ MGP_PWKPhJ_G0027700
protein coding gene Chr4:124070326-124116671 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027526
protein coding gene Chr4:126808483-126853934 (-)
WSB/EiJ MGP_WSBEiJ_G0028059
protein coding gene Chr4:131089777-131134385 (-)



Homology
more
  • Human Ortholog
    ZCCHC17, zinc finger CCHC-type containing 17
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ZCCHC17, zinc finger CCHC-type containing 17
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPC251, pNO40, PS1D
  • Links
    NCBI Gene ID: 51538
    neXtProt AC: NX_Q9NP64
    UniProt: Q9NP64

  • Chr Location
    1p35.2; chr1:31296982-31365764 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Specific KO of the short isoform reduces osteogenic differentiation of mesenchymal stem cells and results in early cellular senescence in the embryonic notochord and forelimb bones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 619605 NCBI Gene Model | MGI Sequence Detail 44062 C57BL/6J ±  kb
transcript NM_153160 RefSeq | MGI Sequence Detail 2162 C57BL/6  
polypeptide Q9ESX4 UniProt | EBI | MGI Sequence Detail 241 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 84
    cDNA 83
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:233160 Lin YM, et al., Target disruption of ribosomal protein pNO40 accelerates aging and impairs osteogenic differentiation of mesenchymal stem cells. Biochem Biophys Res Commun. 2016 Jan 22;469(4):903-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory