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Hnrnpll Gene Detail
Summary
  • Symbol
    Hnrnpll
  • Name
    heterogeneous nuclear ribonucleoprotein L-like
  • Synonyms
    2510028H02Rik, 2810036L13Rik, Hnrpll
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919942
    NCBI Gene: 72692
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80336916-80369697 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    909 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919942
 protein coding gene Chr17:80336916-80369697 (-)
129S1/SvImJ ENSMUSG00200024415
 protein coding gene Chr17:75704073-75736917 (-)
A/J ENSMUSG00195027273
 protein coding gene Chr17:77074715-77107486 (-)
AKR/J ENSMUSG00220013370
 protein coding gene Chr17:75989560-76022801 (-)
BALB/cJ ENSMUSG00180004697
 protein coding gene Chr17:76777364-76810110 (-)
C3H/HeJ ENSMUSG00175015083
 protein coding gene Chr17:76048391-76081125 (-)
C57BL/6NJ ENSMUSG00215010474
 protein coding gene Chr17:75764167-75797021 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021900
 protein coding gene Chr17:75757787-75791074 (-)
CAST/EiJ ENSTCUG00005014981
 protein coding gene Chr17:76635749-76668495 (-)
CBA/J ENSMUSG00210019851
 protein coding gene Chr17:75909822-75942656 (-)
DBA/2J ENSMUSG00185012489
 protein coding gene Chr17:78743350-78776081 (-)
FVB/NJ ENSMUSG00205028848
 protein coding gene Chr17:76525448-76558298 (-)
JF1/MsJ ENSUMUG00000008835
 protein coding gene Chr17:78468602-78501838 (-)
LP/J ENSMUSG00230021081
 protein coding gene Chr17:79744871-79777689 (-)
NOD/ShiLtJ ENSMUSG00190009369
 protein coding gene Chr17:75810221-75842960 (-)
NZO/HlLtJ ENSMUSG00225030304
 protein coding gene Chr17:82019276-82128378 (-)
PWK/PhJ ENSLUMG00010005248
 protein coding gene Chr17:75689171-75722305 (-)
SPRET/EiJ ENSMSPG00010007721
 protein coding gene Chr17:76193717-76227392 (-)
WSB/EiJ ENSIUOG00005009773
 protein coding gene Chr17:76733508-76766089 (-)



Homology
more
  • Human Ortholog
    HNRNPLL, heterogeneous nuclear ribonucleoprotein L like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPLL, heterogeneous nuclear ribonucleoprotein L like
  • Synonyms
    HNRPLL, SRRF
  • Links
    NCBI Gene ID: 92906
    UniProt: Q8WVV9

  • Chr Location
    2p22.1; chr2:38561969-38603586 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a point mutation in a RNA recognition motif of the gene product have defects in the generation of alternative transcripts normally found in memory T cells. Total CD4+ T cell counts are lower, with a reduction of nave CD44lo T cells occurring as mice age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    22
  • cDNA Data
    110
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 72692 NCBI Gene Model | MGI Sequence Detail 32782 C57BL/6J ±  kb
transcript NR_152119 RefSeq | MGI Sequence Detail 3133 C57BL/6  
polypeptide Q921F4 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008677 heterogeneous nuclear ribonucleoprotein L-like
    (term hierarchy)
  • PDB
    1WEX, 2E5I
  • InterPro Domains
    IPR055204 Heterogeneous nuclear ribonucleoprotein L, RRM domain
    IPR006536 HnRNP-L/PTB
    IPR034985 hnRPLL, RNA recognition motif 1
    IPR034986 hnRPLL, RNA recognition motif 2
    IPR034983 hnRPLL, RNA recognition motif 3
    IPR034987 hnRPLL, RNA recognition motif 4
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR021790 PTBP1-like, RNA recognition motif 2
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
  • GlyGen
    Q921F4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 113
    cDNA 112
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1919699, MGI:2146812, MGI:2146941
References
more
  • Summaries
    All 52
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:53501 Borchert A, et al., Cloning of the mouse phospholipid hydroperoxide glutathione peroxidase gene. FEBS Lett. 1999 Mar 12;446(2-3):223-7
  • Latest
    J:353724 Subramani PG, et al., Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation. EMBO Rep. 2024 Jun;25(6):2662-2697
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory