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Hnrnpll Gene Detail
Summary
  • Symbol
    Hnrnpll
  • Name
    heterogeneous nuclear ribonucleoprotein L-like
  • Synonyms
    2510028H02Rik, 2810036L13Rik, Hnrpll
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919942
    NCBI Gene: 72692
  • Gene Overview
    MyGene.info: HNRNPLL
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:80029487-80062268 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 50.30 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919942
 protein coding gene Chr17:80029487-80062334 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024055
 protein coding gene Chr17:82915792-82949272 (-)
A/J MGP_AJ_G0024012
 protein coding gene Chr17:80376831-80410633 (-)
AKR/J MGP_AKRJ_G0023981
 protein coding gene Chr17:81623224-81656803 (-)
BALB/cJ MGP_BALBcJ_G0024014
 protein coding gene Chr17:80257223-80290767 (-)
C3H/HeJ MGP_C3HHeJ_G0023778
 protein coding gene Chr17:82506605-82540130 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024458
 protein coding gene Chr17:85941604-85977199 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021900
 protein coding gene Chr17:75757787-75791074 (-)
CAST/EiJ MGP_CASTEiJ_G0023258
 protein coding gene Chr17:83175739-83209178 (-)
CBA/J MGP_CBAJ_G0023752
 protein coding gene Chr17:89513698-89551282 (-)
DBA/2J MGP_DBA2J_G0023881
 protein coding gene Chr17:78891230-78924572 (-)
FVB/NJ MGP_FVBNJ_G0023847
 protein coding gene Chr17:78384219-78420540 (-)
LP/J MGP_LPJ_G0023964
 protein coding gene Chr17:83765725-83799534 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023875
 protein coding gene Chr17:89585878-89622875 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024503
 protein coding gene Chr17:82099014-82140943 (-)
PWK/PhJ MGP_PWKPhJ_G0023004
 protein coding gene Chr17:78413813-78450537 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022815
 protein coding gene Chr17:78892690-78927283 (-)
WSB/EiJ MGP_WSBEiJ_G0023325
 protein coding gene Chr17:82929617-82964615 (-)



Homology
more
  • Human Ortholog
    HNRNPLL, heterogeneous nuclear ribonucleoprotein L like
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HNRNPLL, heterogeneous nuclear ribonucleoprotein L like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HNRPLL, SRRF
  • Links
    NCBI Gene ID: 92906
    neXtProt AC: NX_Q8WVV9
    UniProt: Q8WVV9

  • Chr Location
    2p22.1; chr2:38563186-38603036 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a point mutation in a RNA recognition motif of the gene product have defects in the generation of alternative transcripts normally found in memory T cells. Total CD4+ T cell counts are lower, with a reduction of nave CD44lo T cells occurring as mice age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    653
  • Tissues
    22
  • cDNA Data
    110
  • Literature Summary
    2
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72692 NCBI Gene Model | MGI Sequence Detail 32782 C57BL/6J ±  kb
transcript NR_152119 RefSeq | MGI Sequence Detail 3133 C57BL/6  
polypeptide Q921F4 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 113
    cDNA 112
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1919699, MGI:2146812, MGI:2146941
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:53501 Borchert A, et al., Cloning of the mouse phospholipid hydroperoxide glutathione peroxidase gene. FEBS Lett. 1999 Mar 12;446(2-3):223-7
  • Latest
    J:247195 Peng Y, et al., Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells. J Biol Chem. 2017 Jul 21;292(29):12285-12295
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/13/2020
MGI 6.16 		The Jackson Laboratory