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Exosc6
Gene Detail
 Symbol
Name
ID
Exosc6
exosome component 6
MGI:1919794
Synonyms 2610510N21Rik, Mtr3
Feature Type protein coding gene
Genetic Map
Chromosome 8
57.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:111056339-111057599 bp, + strand
From NCBI annotation of GRCm38

  1261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12469  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 3 western clawed frog; 1 zebrafish

Human
homologs
Human Homolog EXOSC6, exosome component 6
NCBI Gene ID 118460
neXtProt AC  NX_Q5RKV6
Human Synonyms  EAP4, hMtr3p, MTR3, Mtr3p, p11
Human Chr (Location)  16q22.1; chr16:70250231-70251930 (-)  GRCh38
Interactions
Exosc6 interacts with 4 markers (Mir504, Mir3071, Mir3960, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process DNA deamination, isotype switching, ...
Component cytoplasm, exosome (RNase complex), ...
Function poly(A) RNA binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (49)    Tissues (30)    Images (19)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 49
cDNA source data(7)
External Resources: Allen Institute   GEO  
Molecular
reagents
All nucleic(8) Genomic(1) cDNA(7)
Microarray probesets(2)
Other database
links
Entrez Gene72544 (Evidence)
DFCITC1579517, TC1612869
International Mouse Knockout Project StatusExosc6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72544 NCBI Gene Model | MGI Sequence Detail 1261 C57BL/6J ±  kb
transcript NM_028274 RefSeq | MGI Sequence Detail 1346 Not Specified 
polypeptide Q8BTW3 UniProt | EBI | MGI Sequence Detail 273 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001247 Exoribonuclease, phosphorolytic domain 1
InterPro IPR015847 Exoribonuclease, phosphorolytic domain 2
InterPro IPR027408 PNPase/RNase PH domain
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
Protein Ontology PR:000007263 exosome complex component MTR3
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173133 Basu U, et al., The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates. Cell. 2011 Feb 4;144(3):353-63
All references(20)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory