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Pgam5 Gene Detail
Summary
  • Symbol
    Pgam5
  • Name
    phosphoglycerate mutase family member 5
  • Synonyms
    2610528A17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919792
    NCBI Gene: 72542
  • Gene Overview
    MyGene.info: PGAM5
Location & Maps
more
  • Sequence Map
    Chr5:110259130-110269913 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10784 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.43 cM, cytoband F
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PGAM5, PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PGAM5, PGAM family member 5, mitochondrial serine/threonine protein phosphatase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BXLBV68
  • Links
    NCBI Gene ID: 192111
    neXtProt AC: NX_Q96HS1

  • Chr Location
    12q24.33; chr12:132710807-132722737 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    1
  • Gene trapped
    15
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Pgam5
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit Parkinson-like symptoms including bradykinesia, akinesia, dopaminergic neuron loss, reduced dopamine levels and abnormal mitochondria morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026211 VEGA Gene Model | MGI Sequence Detail 10784 C57BL/6J ±  kb
transcript OTTMUST00000064823 VEGA | MGI Sequence Detail 2098 Not Applicable  
polypeptide OTTMUSP00000032226 VEGA | MGI Sequence Detail 288 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    137 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000031092 serine/threonine-protein phosphatase PGAM5, mitochondrial
  • EC
  • InterPro Domains
    IPR029033 Histidine phosphatase superfamily
    IPR013078 Histidine phosphatase superfamily, clade-1
Molecular
Reagents
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  • All nucleic 58
    cDNA 58

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory