About   Help   FAQ
Aldh1b1 Gene Detail
Summary
  • Symbol
    Aldh1b1
  • Name
    aldehyde dehydrogenase 1 family, member B1
  • Synonyms
    2700007F14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919785
    NCBI Gene: 72535
  • Gene Overview
    MyGene.info: ALDH1B1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:45799022-45804604 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5583 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 24.35 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ALDH1B1, aldehyde dehydrogenase 1 family member B1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ALDH1B1, aldehyde dehydrogenase 1 family member B1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALDH5, ALDHX
  • Links
    NCBI Gene ID: 219
    neXtProt AC: NX_P30837
    UniProt: P30837

  • Chr Location
    9p13.1; chr9:38392664-38398665 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased fasting circulating glucose levels and decreased blood acetaldehyde clearance. Mice homozygous for a different knock-out allele display defects in beta cell development and functionality, and develop glucose intolerance, age-dependent hyperglycemia, and insulin resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006730 VEGA Gene Model | MGI Sequence Detail 5583 C57BL/6J ±  kb
    transcript OTTMUST00000015490 VEGA | MGI Sequence Detail 2298 Not Applicable  
    polypeptide OTTMUSP00000007139 VEGA | MGI Sequence Detail 519 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      42 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 75
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:241887 Muller MF, et al., Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice. J Pathol. 2017 Apr;241(5):649-660

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory