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Sec24c Gene Detail
Summary
  • Symbol
    Sec24c
  • Name
    Sec24 related gene family, member C (S. cerevisiae)
  • Synonyms
    2610204K03Rik, mKIAA0079
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919746
    NCBI Gene: 218811
  • Gene Overview
    MyGene.info: SEC24C
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:20674308-20694852 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20545 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SEC24C, SEC24 homolog C, COPII coat complex component
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SEC24C, SEC24 homolog C, COPII coat complex component
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9632
    neXtProt AC: NX_P53992
    UniProt: P53992

  • Chr Location
    10q22.2; chr10:73744164-73772175 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display complete embryonic lethality between implantation and placentation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039367 Ensembl Gene Model | MGI Sequence Detail 20545 C57BL/6J ±  kb
transcript ENSMUST00000048657 Ensembl | MGI Sequence Detail 4461 Not Applicable  
polypeptide ENSMUSP00000045955 Ensembl | MGI Sequence Detail 1096 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    74 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR029006 ADF-H/Gelsolin-like domain superfamily
    IPR007123 Gelsolin-like domain
    IPR036180 Gelsolin-like domain superfamily
    IPR012990 Sec23/Sec24 beta-sandwich
    IPR006900 Sec23/Sec24, helical domain
    IPR036175 Sec23/Sec24 helical domain superfamily
    IPR006896 Sec23/Sec24, trunk domain
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR006895 Zinc finger, Sec23/Sec24-type
    IPR036174 Zinc finger, Sec23/Sec24-type superfamily
Molecular
Reagents
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  • All nucleic 321
    cDNA 320
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:232065 Adams EJ, et al., Mammalian COPII coat component SEC24C is required for embryonic development in mice. J Biol Chem. 2014 Jul 25;289(30):20858-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory