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Prcp Gene Detail
Summary
  • Symbol
    Prcp
  • Name
    prolylcarboxypeptidase (angiotensinase C)
  • Synonyms
    2510048K03Rik, 2610104A14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919711
    NCBI Gene: 72461
  • Gene Overview
    MyGene.info: PRCP
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:92875253-92934581 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 51.64 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    357 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919711
protein coding gene Chr7:92874470-92934583 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032516
protein coding gene Chr7:95438186-95496206 (+)
A/J MGP_AJ_G0032490
protein coding gene Chr7:93054400-93108491 (+)
AKR/J MGP_AKRJ_G0032426
protein coding gene Chr7:95273585-95340343 (+)
BALB/cJ MGP_BALBcJ_G0032501
protein coding gene Chr7:92722302-92776841 (+)
C3H/HeJ MGP_C3HHeJ_G0032216
protein coding gene Chr7:95645881-95708069 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032999
protein coding gene Chr7:99117712-99191679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029994
protein coding gene Chr7:95835919-95886252 (+)
CAST/EiJ MGP_CASTEiJ_G0031543
protein coding gene Chr7:87133033-87193571 (+)
CBA/J MGP_CBAJ_G0032183
protein coding gene Chr7:102472704-102534593 (+)
DBA/2J MGP_DBA2J_G0032335
protein coding gene Chr7:91485000-91546485 (+)
FVB/NJ MGP_FVBNJ_G0032291
protein coding gene Chr7:91322877-91377677 (+)
LP/J MGP_LPJ_G0032424
protein coding gene Chr7:96691375-96756247 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0033021
protein coding gene Chr7:94594340-94662484 (+)
PWK/PhJ MGP_PWKPhJ_G0031261
protein coding gene Chr7:84554890-84609626 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031104
protein coding gene Chr7:81897983-81954664 (+)
WSB/EiJ MGP_WSBEiJ_G0031660
protein coding gene Chr7:95243323-95302235 (+)



Homology
more
  • Human Ortholog
    PRCP, prolylcarboxypeptidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRCP, prolylcarboxypeptidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUMPCP, PCP
  • Links
    NCBI Gene ID: 5547
    neXtProt AC: NX_P42785
    UniProt: P42785

  • Chr Location
    11q14.1; chr11:82822940-82901740 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased body length, weight, and fat pads with resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72461 NCBI Gene Model | MGI Sequence Detail 59329 C57BL/6J ±  kb
    transcript NM_028243 RefSeq | MGI Sequence Detail 2964 C57BL/6  
    polypeptide Q7TMR0 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917679, MGI:2141970
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 36
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:252804 Maier C, et al., Prolylcarboxypeptidase deficiency is associated with increased blood pressure, glomerular lesions, and cardiac dysfunction independent of altered circulating and cardiac angiotensin II. J Mol Med (Berl). 2017 May;95(5):473-486

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory