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Prcp
Gene Detail
Symbol

Name
ID
Prcp
prolylcarboxypeptidase (angiotensinase C)
MGI:1919711
Synonyms
2510048K03Rik, 2610104A14Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
51.64 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:92875253-92934573 bp, + strand
From Ensembl annotation of GRCm38

  59321 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRCP
Protein SuperFamily: Lysosomal Pro-X carboxypeptidase / Dipeptidyl-peptidase 2
Gene Tree: Prcp

Human
homologs
PRCP, prolylcarboxypeptidase (angiotensinase C)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5547
neXtProt AC: NX_P42785

Human Synonyms: HUMPCP, PCP

Human Chr (Location): 11q14; chr11:82824367-82901691 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trap allele exhibit decreased body length, weight, and fat pads with resistance to diet-induced obesity.
 
Interactions
Prcp interacts with 255 markers (Mir1b, Mir7-1, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process angiogenesis involved in wound healing, energy homeostasis, ...
Component basal part of cell, extracellular exosome, ...
Function carboxypeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (225)    Tissues (15)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 225
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PRCP ; Xenbase prcp ; ZFIN prcp    NEW 
Molecular
reagents
All nucleic(57) cDNA(57)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000061119 (Evidence)
Entrez Gene 72461 (Evidence)
UniGene 389969
DFCI TC1577752, TC1701844, TC1594211
DoTS DT.525966, DT.111002796, DT.91319685, DT.94159735
NIA Mouse Gene Index U144563
EC 3.4.16.2
Consensus CDS Project CCDS21452.1
International Mouse Phenotyping Consortium Status Prcp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061119 Ensembl Gene Model | MGI Sequence Detail 59321 C57BL/6J ±  kb
transcript ENSMUST00000076052 Ensembl | MGI Sequence Detail 2956 Not Applicable 
polypeptide ENSMUSP00000075429 Ensembl | MGI Sequence Detail 491 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(373 from dbSNP Build 137)    SNPs within 2kb including multiple locations(397)
Protein-related
information
ResourceIDDescription
InterPro IPR008758 Peptidase S28
Protein Ontology PR:000013179 lysosomal Pro-X carboxypeptidase
References
(Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:201780 Adams GN, et al., Prolylcarboxypeptidase promotes angiogenesis and vascular repair. Blood. 2013 Aug 22;122(8):1522-31
All references(43)
Other
accession IDs
MGI:1917679, MGI:2141970

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory