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Thoc1 Gene Detail
Summary
  • Symbol
    Thoc1
  • Name
    THO complex 1
  • Synonyms
    3110002N20Rik, MGC:28284, NMP-84
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919668
    NCBI Gene: 225160
  • Gene Overview
    MyGene.info: THOC1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:9958180-9995484 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37305 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.91 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    THOC1, THO complex 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    THOC1, THO complex 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPR1, P84, P84N5
  • Links
    NCBI Gene ID: 9984
    neXtProt AC: NX_Q96FV9
    UniProt: Q96FV9

  • Chr Location
    18p11.32; chr18:214348-268059 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38012
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: THOC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in embryonic lethality around implantation in homozygotes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225160 NCBI Gene Model | MGI Sequence Detail 37305 C57BL/6J ±  kb
    transcript NM_153552 RefSeq | MGI Sequence Detail 3855 C57BL/6  
    polypeptide Q8R3N6 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      82 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147345
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236189 Chinnam M, et al., Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice. Mol Cell Biol. 2016 Jun 1;36(11):1621-7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory