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Thoc1
Gene Detail
 Symbol
Name
ID
Thoc1
THO complex 1
MGI:1919668
Synonyms 3110002N20Rik, MGC:28284, NMP-84
Feature Type protein coding gene
Genetic Map
Chromosome 18
4.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:9958180-9995484 bp, + strand
From NCBI annotation of GRCm38

  37305 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38012  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Thoc1

Human
homologs
Human Homolog THOC1, THO complex 1
NCBI Gene ID 9984
neXtProt AC  NX_Q96FV9
Human Synonyms  HPR1, P84, P84N5
Human Chr (Location)  18p11.32; chr18:214520-268059 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(10) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in embryonic lethality around implantation in homozygotes.
 
Interactions
Thoc1 interacts with 283 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process apoptotic process, mRNA export from nucleus, ...
Component cytoplasm, intercellular bridge, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (12)    Tissues (10)    Images (1)
Theiler Stages: 1, 2, 3, 4, 5, 20, 23
Assay TypeResults
Immunohistochemistry 5
RNA in situ 1
RT-PCR 6
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024287 (Evidence)
Entrez Gene225160 (Evidence)
Consensus CDS ProjectCCDS37733.1
International Mouse Knockout Project StatusThoc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 225160 NCBI Gene Model | MGI Sequence Detail 37305 C57BL/6J ±  kb
transcript NM_153552 RefSeq | MGI Sequence Detail 3855 C57BL/6 
polypeptide Q8R3N6 UniProt | EBI | MGI Sequence Detail 657 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR021861 THO complex, subunit THOC1
Protein Ontology PR:000016310 THO complex subunit 1
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:204752 Pitzonka L, et al., The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine. Mol Cell Biol. 2013 Sep;33(17):3505-14
All references(40)
Other
accession IDs
MGI:2147345

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory