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Thoc1 Gene Detail
Summary
  • Symbol
    Thoc1
  • Name
    THO complex 1
  • Synonyms
    3110002N20Rik, MGC:28284, NMP-84
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919668
    NCBI Gene: 225160
  • Gene Overview
    MyGene.info: THOC1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:9958180-9995484 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 4.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919668
protein coding gene Chr18:9958180-9995484 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024144
protein coding gene Chr18:6881620-6924797 (+)
A/J MGP_AJ_G0024106
protein coding gene Chr18:6839454-6876626 (+)
AKR/J MGP_AKRJ_G0024073
protein coding gene Chr18:7008973-7046131 (+)
BALB/cJ MGP_BALBcJ_G0024105
protein coding gene Chr18:6816484-6854464 (+)
C3H/HeJ MGP_C3HHeJ_G0023872
protein coding gene Chr18:6898005-6937686 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024550
protein coding gene Chr18:7297770-7338446 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021989
protein coding gene Chr18:6380304-6417669 (+)
CAST/EiJ MGP_CASTEiJ_G0023349
protein coding gene Chr18:6814181-6853120 (+)
CBA/J MGP_CBAJ_G0023844
protein coding gene Chr18:7322837-7365893 (+)
DBA/2J MGP_DBA2J_G0023973
protein coding gene Chr18:6686841-6727027 (+)
FVB/NJ MGP_FVBNJ_G0023938
protein coding gene Chr18:6652929-6691011 (+)
LP/J MGP_LPJ_G0024056
protein coding gene Chr18:6976181-7026203 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023967
protein coding gene Chr18:7514701-7556991 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024596
protein coding gene Chr18:6832841-6872126 (+)
PWK/PhJ MGP_PWKPhJ_G0023095
protein coding gene Chr18:6728025-6756487 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022905
protein coding gene Chr18:7131729-7178524 (+)
WSB/EiJ MGP_WSBEiJ_G0023415
protein coding gene Chr18:6827932-6866545 (+)



Homology
more
  • Human Ortholog
    THOC1, THO complex 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    THOC1, THO complex 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPR1, P84, P84N5
  • Links
    NCBI Gene ID: 9984
    neXtProt AC: NX_Q96FV9
    UniProt: Q96FV9

  • Chr Location
    18p11.32; chr18:214348-268059 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38012
    1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: THOC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in embryonic lethality around implantation in homozygotes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 225160 NCBI Gene Model | MGI Sequence Detail 37305 C57BL/6J ±  kb
    transcript NM_153552 RefSeq | MGI Sequence Detail 3855 C57BL/6  
    polypeptide Q8R3N6 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2147345
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:236189 Chinnam M, et al., Evaluating Effects of Hypomorphic Thoc1 Alleles on Embryonic Development in Rb1 Null Mice. Mol Cell Biol. 2016 Jun 1;36(11):1621-7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory