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Sgol1 Gene Detail
Summary
  • Symbol
    Sgol1
  • Name
    shugoshin-like 1 (S. pombe)
  • Synonyms
    3300001M08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919665
    NCBI Gene: 72415
  • Gene Overview
    MyGene.info: SGO1
Location & Maps
more
  • Sequence Map
    Chr17:53674786-53689333 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14548 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SGO1, shugoshin 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SGO1, shugoshin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAID, NY-BR-85, SGO, SGOL1
  • Links
    NCBI Gene ID: 151648
    neXtProt AC: NX_Q5FBB7

  • Chr Location
    3p24.3; chr3:20159046-20188131 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SGO1 associations

Human Disease Mouse Models
       Chronic Atrial and Intestinal Dysrhythmia; CAID   OMIM: 616201
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele show prenatal lethality. Heterozygotes display enhanced chromosome instability, as well as increased formation of aberrant crypt foci and accelerated development of colon tumors after exposure to azoxymethane.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024480 VEGA Gene Model | MGI Sequence Detail 14548 C57BL/6J ±  kb
transcript OTTMUST00000060054 VEGA | MGI Sequence Detail 3628 Not Applicable  
polypeptide OTTMUSP00000029273 VEGA | MGI Sequence Detail 517 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    215 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014798 shugoshin-like 1
  • InterPro Domains
    IPR011515 Shugoshin, C-terminal
    IPR011516 Shugoshin, N-terminal coiled-coil domain
Molecular
Reagents
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  • All nucleic 73
    Genomic 1
    cDNA 72

    Microarray probesets 4
Other
Accession IDs
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MGI:2147138
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:220235 Yamada HY, et al., Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice. Carcinogenesis. 2015 Apr;36(4):429-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory