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Kcnmb2 Gene Detail
Summary
  • Symbol
    Kcnmb2
  • Name
    potassium large conductance calcium-activated channel, subfamily M, beta member 2
  • Synonyms
    2700049B16Rik, 3110031N04Rik, MGC:57945
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919663
    NCBI Gene: 72413
  • Gene Overview
    MyGene.info: KCNMB2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:31902507-32200180 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 15.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2605 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919663
protein coding gene Chr3:31902132-32200180 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027134
protein coding gene Chr3:29471549-29776118 (+)
A/J MGP_AJ_G0027094
protein coding gene Chr3:29090597-29403718 (+)
AKR/J MGP_AKRJ_G0027063
protein coding gene Chr3:29542291-29848933 (+)
BALB/cJ MGP_BALBcJ_G0027106
protein coding gene Chr3:28742000-29038353 (+)
C3H/HeJ MGP_C3HHeJ_G0026849
protein coding gene Chr3:29549227-29854435 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027552
protein coding gene Chr3:30997964-31298275 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024913
protein coding gene Chr3:26955895-27235913 (+)
CAST/EiJ MGP_CASTEiJ_G0026302
protein coding gene Chr3:29397345-29718063 (+)
CBA/J MGP_CBAJ_G0026826
protein coding gene Chr3:31807365-32111473 (+)
DBA/2J MGP_DBA2J_G0026960
protein coding gene Chr3:28569226-28858576 (+)
FVB/NJ MGP_FVBNJ_G0026928
protein coding gene Chr3:28041770-28336683 (+)
LP/J MGP_LPJ_G0027072
protein coding gene Chr3:30237161-30557954 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026948
protein coding gene Chr3:34336684-34646510 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027611
protein coding gene Chr3:29301837-29604819 (+)
PWK/PhJ MGP_PWKPhJ_G0026035
protein coding gene Chr3:28110099-28400944 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025847
protein coding gene Chr3:28746906-29035749 (+)
WSB/EiJ MGP_WSBEiJ_G0026376
protein coding gene Chr3:29342850-29633243 (+)



Homology
more
  • Human Ortholog
    KCNMB2, potassium calcium-activated channel subfamily M regulatory beta subunit 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KCNMB2, potassium calcium-activated channel subfamily M regulatory beta subunit 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 10242
    neXtProt AC: NX_Q9Y691
    UniProt: Q9Y691

  • Chr Location
    3q26.32; chr3:178536298-178844429 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037610 Ensembl Gene Model | MGI Sequence Detail 297674 C57BL/6J ±  kb
transcript ENSMUST00000178668 Ensembl | MGI Sequence Detail 2917 Not Applicable  
polypeptide ENSMUSP00000136596 Ensembl | MGI Sequence Detail 235 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009267 calcium-activated potassium channel subunit beta-2
  • InterPro Domains
    IPR015382 KCNMB2, ball/chain domain
    IPR037096 KCNMB2, ball/chain domain superfamily
    IPR003930 Potassium channel, calcium-activated, BK, beta subunit
Molecular
Reagents
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  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1920369
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:240672 Larsen CK, et al., Intact colonic KCa1.1 channel activity in KCNMB2 knockout mice. Physiol Rep. 2017 Mar;5(5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory