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Brap Gene Detail
Summary
  • Symbol
    Brap
  • Name
    BRCA1 associated protein
  • Synonyms
    3010002G07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919649
    NCBI Gene: 72399
Location & Maps
more
  • Sequence Map
    Chr5:121660563-121687256 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26694 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 61.90 cM, cytoband F
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BRAP, BRCA1 associated protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BRAP, BRCA1 associated protein
    Orthology source: HomoloGene
  • Synonyms
    BRAP2, IMP, RNF52
  • Links
    NCBI Gene ID: 8315
    neXtProt AC: NX_Q7Z569

  • Chr Location
    12q24; chr12:111642146-111685996 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Brap
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis and subtle defects in cell cycle-dependent nuclear movement in neural progenitors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023519 VEGA Gene Model | MGI Sequence Detail 26694 C57BL/6J ±  kb
transcript OTTMUST00000057309 VEGA | MGI Sequence Detail 3744 Not Applicable  
polypeptide OTTMUSP00000027628 VEGA | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    125 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 78

    Microarray probesets 5
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:227444 Fatima S, et al., Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. Sci Rep. 2015;5:9459

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory