About   Help   FAQ
Faim2 Gene Detail
Summary
  • Symbol
    Faim2
  • Name
    Fas apoptotic inhibitory molecule 2
  • Synonyms
    2900002L20Rik, Lfg, lifeguard, mKIAA0950, NMP25, Tmbim2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919643
    NCBI Gene: 72393
Location & Maps
more
  • Sequence Map
    Chr15:99497005-99528017 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31013 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.13 cM, cytoband F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FAIM2, Fas apoptotic inhibitory molecule 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAIM2, Fas apoptotic inhibitory molecule 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LFG, LFG2, NGP35, NMP35, TMBIM2
  • Links
    NCBI Gene ID: 23017
    neXtProt AC: NX_Q9BWQ8

  • Chr Location
    12q13; chr12:49866896-49903977 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Faim2
  • Incidental Mutations
A mutation in this gene results in kidney abnormalities including enlargement and dilation. A reduced seizure threshold in response to pharmacological agents is also observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023011 Ensembl Gene Model | MGI Sequence Detail 31013 C57BL/6J ±  kb
transcript ENSMUST00000023750 Ensembl | MGI Sequence Detail 4520 Not Applicable  
polypeptide ENSMUSP00000023750 Ensembl | MGI Sequence Detail 317 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    306 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007328 protein lifeguard 2
  • InterPro Domains
    IPR006214 Bax inhibitor 1-related
Molecular
Reagents
less
  • All nucleic 39
    cDNA 38
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146095
References
more
  • Summaries
    All 35
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 25
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:191236 Wang SZ, et al., Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18589-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory