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Faim2
Gene Detail
Symbol

Name
ID
Faim2
Fas apoptotic inhibitory molecule 2
MGI:1919643
Synonyms
2900002L20Rik, Lfg, lifeguard, mKIAA0950, NMP25, Tmbim2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.13 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:99497005-99528017 bp, - strand
From NCBI annotation of GRCm38

  31013 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8192  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: glutamate binding protein 1, vertebrate type
Gene Tree: Faim2

Human
homologs
Human Homolog FAIM2, Fas apoptotic inhibitory molecule 2
NCBI Gene ID 23017
neXtProt AC  NX_Q9BWQ8
Human Synonyms  LFG, LFG2, NGP35, NMP35, TMBIM2
Human Chr (Location)  12q13; chr12:49866896-49903977 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Radiation induced(1) Targeted(4)
Genomic Mutations involving Faim2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
A mutation in this gene results in kidney abnormalities including enlargement and dilation. A reduced seizure threshold in response to pharmacological agents is also observed.
 
Interactions
Faim2 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process apoptotic process, cerebellar granular layer development, ...
Component cell junction, integral component of membrane, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (61)    Tissues (41)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 23
RT-PCR 38
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000023011 (Evidence)
Entrez Gene72393 (Evidence)
UniGene39760
DFCITC1578045, TC1597689, TC1602804, TC1752716
DoTSDT.101327934, DT.110789259, DT.110789271, DT.50315439, DT.55211225, DT.97361288
Consensus CDS ProjectCCDS37203.1
International Mouse Knockout Project StatusFaim2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72393 NCBI Gene Model | MGI Sequence Detail 31013 C57BL/6J ±  kb
transcript NM_028224 RefSeq | MGI Sequence Detail 4668 C57BL/6 
polypeptide Q8K097 UniProt | EBI | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006214 Bax inhibitor 1-related
Protein Ontology PR:000007328 protein lifeguard 2
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:191236 Wang SZ, et al., Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18589-94
All references(39)
Other
accession IDs
MGI:2146095

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory