Faim2
Gene Detail

Symbol Name ID

Faim2 Fas apoptotic inhibitory molecule 2 MGI:1919643

Synonyms

2900002L20Rik, Lfg, lifeguard, mKIAA0950, NMP25

Feature Type

protein coding gene

Genetic Map

Chromosome 15

56.13 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:99497005-99528017 bp, - strand From NCBI annotation of GRCm38   31013 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Faim2 ± 2 cM)

Protein SuperFamily: glutamate binding protein 1, vertebrate type
Gene Tree: Faim2

Human ortholog

FAIM2 Fas apoptotic inhibitory molecule 2 NCBI Gene ID 23017
Human Synonyms: LFG, LFG2, NGP35, NMP35, TMBIM2
Human Chr12:50260680-50297720 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(9) : Targeted(4) Gene trapped(5)
 

A mutation in this gene results in kidney abnormalities including enlargement and dilation. A reduced seizure threshold in response to pharmacological agents is also observed.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	apoptotic process, cerebellar granular layer development, ...
Component	cell junction, integral to membrane, ...
Function	molecular_function

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (61)    Tissues (41)    Images (10)
Theiler Stages: 28

Assay Type	Results
In situ reporter (knock in)	23
RT-PCR	38

cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000023011 (Evidence)
Entrez Gene	72393 (Evidence)
UniGene	39760
DFCI	TC1578045, TC1597689, TC1602804, TC1752716
DoTS	DT.101327934, DT.110789259, DT.110789271, DT.50315439, DT.55211225, DT.97361288
Consensus CDS Project	CCDS37203.1
International Mouse Knockout Project Status	Faim2

Sequences

Length	Strain/Species
genomic	72393	NCBI Gene Model | MGI Sequence Detail	31013	C57BL/6J
transcript	NM_028224	RefSeq | MGI Sequence Detail	4668	C57BL/6
polypeptide	Q8K097	UniProt | EBI | MGI Sequence Detail	317	Not Applicable

All sequences(31) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(208 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006214	Bax inhibitor 1-related
Protein Ontology	PR:000007328	Fas apoptotic inhibitory molecule 2

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:191236 Wang SZ, et al., Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18589-94
All references(39)

Other accession IDs

MGI:2146095