About   Help   FAQ
Ehd4
Gene Detail
 Symbol
Name
ID
Ehd4
EH-domain containing 4
MGI:1919619
Synonyms 2210022F10Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
60.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:120089175-120154606 bp, - strand
From VEGA annotation of GRCm38

  65432 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:26430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ehd4

Human
homologs
Human Homolog EHD4, EH-domain containing 4
NCBI Gene ID 30844
neXtProt AC  NX_Q9H223
Human Synonyms  PAST4
Human Chr (Location)  15q11.1; chr15:41899440-41972557 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced male fertility.
 
Interactions
Ehd4 interacts with 227 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to growth factor stimulus, endocytic recycling, ...
Component endoplasmic reticulum, endosome, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (39)    Tissues (9)    Images (18)
Theiler Stages: 23
Assay TypeResults
RNA in situ 39
cDNA source data(106)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(106) cDNA(106)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000015289 (Evidence)
Ensembl Gene ModelENSMUSG00000027293 (Evidence)
Entrez Gene98878 (Evidence)
UniGene132226
DFCITC1572986, TC1617085
DoTSDT.490176, DT.94125464, DT.94365642
NIA Mouse Gene IndexU023239
Consensus CDS ProjectCCDS16615.1
International Mouse Knockout Project StatusEhd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015289 VEGA Gene Model | MGI Sequence Detail 65432 C57BL/6J ±  kb
transcript OTTMUST00000036244 VEGA | MGI Sequence Detail 3730 Not Applicable 
polypeptide OTTMUSP00000016279 VEGA | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(2) UniProt(7)
Polymorphisms SNPs within 2kb(559 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001401 Dynamin, GTPase domain
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR000261 EPS15 homology (EH)
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006945 EH domain-containing protein 4
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:2138861, MGI:2139070, MGI:2139230

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory