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Ehd4
Gene Detail
Symbol

Name
ID
Ehd4
EH-domain containing 4
MGI:1919619
Synonyms
2210022F10Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
60.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:120089175-120154606 bp, - strand
From VEGA annotation of GRCm38

  65432 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:26430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EHD4
Gene Tree: Ehd4

Human
homologs
EHD4, EH-domain containing 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 30844
neXtProt AC: NX_Q9H223

Human Synonyms: PAST4

Human Chr (Location): 15q11.1; chr15:41899440-41972557 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced male fertility.
 
Interactions
Ehd4 interacts with 226 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cellular response to growth factor stimulus, endocytic recycling, ...
Component endoplasmic reticulum, endosome, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (39)    Tissues (9)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
cDNA source data(106)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ehd4 ; ZFIN ehd4    NEW 
Molecular
reagents
All nucleic(106) cDNA(106)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000015289 (Evidence)
Ensembl Gene Model ENSMUSG00000027293 (Evidence)
Entrez Gene 98878 (Evidence)
UniGene 132226
DFCI TC1617085, TC1572986
DoTS DT.94365642, DT.490176, DT.94125464
NIA Mouse Gene Index U023239
Consensus CDS Project CCDS16615.1
International Mouse Phenotyping Consortium Status Ehd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015289 VEGA Gene Model | MGI Sequence Detail 65432 C57BL/6J ±  kb
transcript OTTMUST00000036244 VEGA | MGI Sequence Detail 3730 Not Applicable 
polypeptide OTTMUSP00000016279 VEGA | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(559 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR000261 EPS15 homology (EH)
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006945 EH domain-containing protein 4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)
Other
accession IDs
MGI:2138861, MGI:2139070, MGI:2139230

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory