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Ttc4 Gene Detail
Summary
  • Symbol
    Ttc4
  • Name
    tetratricopeptide repeat domain 4
  • Synonyms
    2810002P21Rik, L62
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919604
    NCBI Gene: 72354
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:106519453-106536141 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 49.68 cM, cytoband C7
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919604
protein coding gene Chr4:106514952-106536188 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028524
protein coding gene Chr4:107299643-107316333 (-)
A/J MGP_AJ_G0028487
protein coding gene Chr4:103467428-103484118 (-)
AKR/J MGP_AKRJ_G0028434
protein coding gene Chr4:105980771-105997457 (-)
BALB/cJ MGP_BALBcJ_G0028506
protein coding gene Chr4:103655333-103672060 (-)
C3H/HeJ MGP_C3HHeJ_G0028220
protein coding gene Chr4:106734494-106751221 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028946
protein coding gene Chr4:111171534-111188222 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026237
protein coding gene Chr4:98744224-98760979 (-)
CAST/EiJ MGP_CASTEiJ_G0027656
protein coding gene Chr4:104534392-104551414 (-)
CBA/J MGP_CBAJ_G0028189
protein coding gene Chr4:114758807-114775534 (-)
DBA/2J MGP_DBA2J_G0028337
protein coding gene Chr4:103084392-103101068 (-)
FVB/NJ MGP_FVBNJ_G0028305
protein coding gene Chr4:101940140-101957560 (-)
LP/J MGP_LPJ_G0028438
protein coding gene Chr4:107499826-107516516 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028331
protein coding gene Chr4:120083083-120099810 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028982
protein coding gene Chr4:106229762-106246439 (-)
PWK/PhJ MGP_PWKPhJ_G0027382
protein coding gene Chr4:101320274-101337338 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027206
protein coding gene Chr4:103611594-103628549 (-)
WSB/EiJ MGP_WSBEiJ_G0027737
protein coding gene Chr4:106401401-106421066 (-)



Homology
more
  • Human Ortholog
    TTC4, tetratricopeptide repeat domain 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTC4, tetratricopeptide repeat domain 4
  • Synonyms
    CNS1
  • Links
    NCBI Gene ID: 7268
    neXtProt AC: NX_O95801
    UniProt: O95801

  • Chr Location
    1p32.3; chr1:54715861-54742657 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025413 Ensembl Gene Model | MGI Sequence Detail 16689 C57BL/6J ±  kb
transcript ENSMUST00000026480 Ensembl | MGI Sequence Detail 2121 Not Applicable  
polypeptide ENSMUSP00000026480 Ensembl | MGI Sequence Detail 386 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 95
    cDNA 95

    Microarray probesets 4
Other
Accession IDs
less
MGI:1354750
References
more
  • Summaries
    All 43
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:47962 Jurecic R, et al., Identification and cloning of differentially expressed genes by long-distance differential display. Anal Biochem. 1998 Jun 1;259(2):235-44
  • Latest
    J:277869 Dmitriev RI, et al., Two distinct nuclear localization signals in mammalian MSL1 regulate its function. J Cell Biochem. 2014 Nov;115(11):1967-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory