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Dusp3 Gene Detail
Summary
  • Symbol
    Dusp3
  • Name
    dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
  • Synonyms
    2210015O03Rik, 5031436O03Rik, T-DSP11, VHR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919599
    NCBI Gene: 72349
  • Gene Overview
    MyGene.info: DUSP3
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101971141-101987005 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 65.48 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919599
protein coding gene Chr11:101971141-101987013 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019215
protein coding gene Chr11:104912549-104928395 (-)
A/J MGP_AJ_G0019183
protein coding gene Chr11:100481818-100497991 (-)
AKR/J MGP_AKRJ_G0019152
protein coding gene Chr11:103594273-103612204 (-)
BALB/cJ MGP_BALBcJ_G0019157
protein coding gene Chr11:100966460-100982324 (-)
C3H/HeJ MGP_C3HHeJ_G0018966
protein coding gene Chr11:103799947-103815790 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019606
protein coding gene Chr11:108184861-108200705 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017232
protein coding gene Chr11:97905737-97922239 (-)
CAST/EiJ MGP_CASTEiJ_G0018520
protein coding gene Chr11:104764188-104780395 (-)
CBA/J MGP_CBAJ_G0018935
protein coding gene Chr11:112649523-112665367 (-)
DBA/2J MGP_DBA2J_G0019047
protein coding gene Chr11:100007375-100023566 (-)
FVB/NJ MGP_FVBNJ_G0019037
protein coding gene Chr11:99533851-99549763 (-)
LP/J MGP_LPJ_G0019116
protein coding gene Chr11:105429175-105445190 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019068
protein coding gene Chr11:112178477-112194334 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019644
protein coding gene Chr11:103956348-103972173 (-)
PWK/PhJ MGP_PWKPhJ_G0018283
protein coding gene Chr11:101067312-101083446 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018075
protein coding gene Chr11:103698479-103719736 (-)
WSB/EiJ MGP_WSBEiJ_G0018569
protein coding gene Chr11:103941580-103957391 (-)



Homology
more
  • Human Ortholog
    DUSP3, dual specificity phosphatase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUSP3, dual specificity phosphatase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    VHR
  • Links
    NCBI Gene ID: 1845
    neXtProt AC: NX_P51452
    UniProt: P51452

  • Chr Location
    17q21.31; chr17:43766121-43779000 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased hemoglobin content and angiogenesis in Matrigel plugs and aortic explants.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72349 NCBI Gene Model | MGI Sequence Detail 15865 C57BL/6J ±  kb
    transcript NM_028207 RefSeq | MGI Sequence Detail 4204 C57BL/6  
    polypeptide Q9D7X3 UniProt | EBI | MGI Sequence Detail 185 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
    • InterPro Domains
      IPR020417 Atypical dual specificity phosphatase
      IPR020405 Atypical dual specificity phosphatase, subfamily A
      IPR024950 Dual specificity phosphatase
      IPR000340 Dual specificity phosphatase, catalytic domain
      IPR020422 Dual specificity protein phosphatase domain
      IPR016130 Protein-tyrosine phosphatase, active site
      IPR029021 Protein-tyrosine phosphatase-like
      IPR000387 Tyrosine specific protein phosphatases domain
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923216
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:250721 Vandereyken MM, et al., Dual-Specificity Phosphatase 3 Deletion Protects Female, but Not Male, Mice from Endotoxemia-Induced and Polymicrobial-Induced Septic Shock. J Immunol. 2017 Oct 1;199(7):2515-2527

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory