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Dusp3 Gene Detail
Summary
  • Symbol
    Dusp3
  • Name
    dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
  • Synonyms
    2210015O03Rik, 5031436O03Rik, T-DSP11, VHR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919599
    NCBI Gene: 72349
  • Gene Overview
    MyGene.info: DUSP3
Location & Maps
more
  • Sequence Map
    Chr11:101971143-101987013 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15871 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DUSP3, dual specificity phosphatase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DUSP3, dual specificity phosphatase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    VHR
  • Links
    NCBI Gene ID: 1845
    neXtProt AC: NX_P51452

  • Chr Location
    17q21; chr17:43766121-43779000 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Genomic Mutations
    1 involving Dusp3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002139 VEGA Gene Model | MGI Sequence Detail 15871 C57BL/6J ±  kb
transcript OTTMUST00000004350 VEGA | MGI Sequence Detail 4311 Not Applicable  
polypeptide OTTMUSP00000002062 VEGA | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    52 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006753 dual specificity protein phosphatase 3
  • EC
  • InterPro Domains
    IPR020417 Atypical dual specificity phosphatase
    IPR020405 Atypical dual specificity phosphatase, subfamily A
    IPR024950 Dual specificity phosphatase
    IPR000340 Dual specificity phosphatase, catalytic domain
    IPR020422 Dual specificity protein phosphatase domain
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 6
Other
Accession IDs
less
MGI:1923216
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:225710 Tuck E, et al., A gene expression resource generated by genome-wide lacZ profiling in the mouse. Dis Model Mech. 2015 Nov 1;8(11):1467-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory