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Dusp3
Gene Detail
Symbol

Name
ID
Dusp3
dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
MGI:1919599
Synonyms
2210015O03Rik, 5031436O03Rik, T-DSP11, VHR
Feature Type
protein coding gene
Genetic Map
Chromosome 11
65.48 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101971143-101987013 bp, - strand
From VEGA annotation of GRCm38

  15871 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20870  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dual specificity phosphoprotein phosphatase DUSP3
Gene Tree: Dusp3

Human
homologs
Human Homolog DUSP3, dual specificity phosphatase 3
NCBI Gene ID 1845
neXtProt AC  NX_P51452
Human Synonyms  VHR
Human Chr (Location)  17q21; chr17:43766121-43779000 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dusp3 interacts with 305 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process dephosphorylation, inactivation of MAPK activity, ...
Component cytoplasm, cytosol, ...
Function hydrolase activity, MAP kinase phosphatase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (71)    Tissues (44)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 71
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000002139 (Evidence)
Ensembl Gene ModelENSMUSG00000003518 (Evidence)
Entrez Gene72349 (Evidence)
DFCITC1599931, TC1584342
DoTSDT.101162498, DT.529429, DT.101233429, DT.492373
NIA Mouse Gene IndexU033461
EC3.1.3.48, 3.1.3.16
Consensus CDS ProjectCCDS25482.1
International Mouse Knockout Project StatusDusp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002139 VEGA Gene Model | MGI Sequence Detail 15871 C57BL/6J ±  kb
transcript OTTMUST00000004350 VEGA | MGI Sequence Detail 4311 Not Applicable 
polypeptide OTTMUSP00000002062 VEGA | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(8) UniProt(11)
Polymorphisms
SNPs within 2kb(52 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020417 Atypical dual specificity phosphatase
InterPro IPR020405 Atypical dual specificity phosphatase, subfamily A
InterPro IPR024950 Dual specificity phosphatase
InterPro IPR000340 Dual specificity phosphatase, catalytic domain
InterPro IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
Protein Ontology PR:000006753 dual specificity protein phosphatase 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:198483 Finelli MJ, et al., Differential phosphorylation of Smad1 integrates BMP and neurotrophin pathways through Erk/Dusp in axon development. Cell Rep. 2013 May 30;3(5):1592-606
All references(41)
Other
accession IDs
MGI:1923216

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory