About   Help   FAQ
Amer1
Gene Detail
Symbol

Name
ID
Amer1
APC membrane recruitment 1
MGI:1919595
Synonyms
2810002O09Rik, Amer1, Fam123b, Wtx
Feature Type
protein coding gene
Genetic Map
Chromosome X
41.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:95420318-95444872 bp, - strand
From VEGA annotation of GRCm38

  24555 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:51852  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Amer1

Human
homologs
Human Homolog AMER1, APC membrane recruitment protein 1
NCBI Gene ID 139285
neXtProt AC  NX_Q5JTC6
Human Synonyms  FAM123B, OSCS, WTX
Human Chr (Location)  Xq11.2; chrX:64185117-64205744 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human AMER1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from APF )
 
Male mice hemizygous for a null mutation display neonatal lethality with cardiac overgrowth, bone overgrowth, bilateral or unilateral renal agenesis coupled with renal overgrowth, adipocyte and spleen hypoplasia, and altered mesenchymal progenitor cell fate specification.
 
Human Diseases Modeled Using Mouse Amer1 (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Amer1 interacts with 505 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process adipose tissue development, bone development, ...
Component cytoplasm, membrane, ...
Function beta-catenin binding, lipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (148)    Tissues (106)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
RT-PCR 3
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(35) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018053 (Evidence)
Ensembl Gene ModelENSMUSG00000050332 (Evidence)
Entrez Gene72345 (Evidence)
UniGene182867
DFCITC1598485, TC1585342
DoTSDT.485496, DT.101251222
NIA Mouse Gene IndexU045232
Consensus CDS ProjectCCDS41067.1
International Mouse Knockout Project StatusAmer1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018053 VEGA Gene Model | MGI Sequence Detail 24555 C57BL/6J ±  kb
transcript OTTMUST00000043578 VEGA | MGI Sequence Detail 8496 Not Applicable 
polypeptide OTTMUSP00000019582 VEGA | MGI Sequence Detail 1132 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019003 Uncharacterised protein family FAM123
Protein Ontology PR:000029267 APC membrane recruitment protein 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)
Disease annotation references (1)
Other
accession IDs
MGI:2148012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory