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Usp36 Gene Detail
Summary
  • Symbol
    Usp36
  • Name
    ubiquitin specific peptidase 36
  • Synonyms
    2700002L06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919594
    NCBI Gene: 72344
  • Gene Overview
    MyGene.info: USP36
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118259651-118290244 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 83.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919594
protein coding gene Chr11:118259651-118290244 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019463
protein coding gene Chr11:122581292-122611907 (-)
A/J MGP_AJ_G0019431
protein coding gene Chr11:117144032-117175484 (-)
AKR/J MGP_AKRJ_G0019401
protein coding gene Chr11:120696655-120731029 (-)
BALB/cJ MGP_BALBcJ_G0019406
protein coding gene Chr11:117506683-117537142 (-)
C3H/HeJ MGP_C3HHeJ_G0019212
protein coding gene Chr11:121000566-121033109 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019855
protein coding gene Chr11:126324842-126357221 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017480
protein coding gene Chr11:114153392-114184436 (-)
CAST/EiJ MGP_CASTEiJ_G0018766
protein coding gene Chr11:122426509-122459062 (-)
CBA/J MGP_CBAJ_G0019183
protein coding gene Chr11:131260637-131290997 (-)
DBA/2J MGP_DBA2J_G0019295
protein coding gene Chr11:116531793-116562304 (-)
FVB/NJ MGP_FVBNJ_G0019287
protein coding gene Chr11:116171471-116202546 (-)
LP/J MGP_LPJ_G0019365
protein coding gene Chr11:122893389-122923969 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019320
protein coding gene Chr11:130227694-130259659 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019894
protein coding gene Chr11:121355284-121387129 (-)
PWK/PhJ MGP_PWKPhJ_G0018532
protein coding gene Chr11:117901806-117932698 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018324
protein coding gene Chr11:121081393-121112123 (-)
WSB/EiJ MGP_WSBEiJ_G0018818
protein coding gene Chr11:121320358-121351064 (-)



Homology
more
  • Human Ortholog
    USP36, ubiquitin specific peptidase 36
  • Vertebrate Orthologs
    8
  • Human Ortholog
    USP36, ubiquitin specific peptidase 36
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DUB1
  • Links
    NCBI Gene ID: 57602
    neXtProt AC: NX_Q9P275
    UniProt: Q9P275

  • Chr Location
    17q25.3; chr17:78787381-78840898 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele display lethality before implantation and arrest at the morula stage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 72344 NCBI Gene Model | MGI Sequence Detail 30594 C57BL/6J ±  kb
transcript NM_001033528 RefSeq | MGI Sequence Detail 5609 C57BL/6  
polypeptide B1AQJ2 UniProt | EBI | MGI Sequence Detail 1098 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    cDNA 59

    Microarray probesets 7
References
more
  • Summaries
    All 34
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:257189 Fraile JM, et al., Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice. J Biol Chem. 2018 Feb 9;293(6):2183-2194

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory