Lsm12 MGI Mouse Gene Detail - MGI:1919592

Symbol

Lsm12
Name

LSM12 homolog
Synonyms

1110032E16Rik, 2600001B17Rik

Feature Type

protein coding gene
IDs

MGI:1919592
NCBI Gene: 268490
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:102053323-102076122 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.60 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

1022 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919592	protein coding gene	Chr11:102053323-102077089 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019224	protein coding gene	Chr11:105115056-105137986 (-)
A/J	MGP_AJ_G0019192	protein coding gene	Chr11:100675830-100699132 (-)
AKR/J	MGP_AKRJ_G0019161	protein coding gene	Chr11:103793709-103818778 (-)
BALB/cJ	MGP_BALBcJ_G0019166	protein coding gene	Chr11:101159976-101187276 (-)
C3H/HeJ	MGP_C3HHeJ_G0018975	protein coding gene	Chr11:103996539-104020328 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019615	protein coding gene	Chr11:108387232-108411495 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017241	protein coding gene	Chr11:98105539-98128977 (-)
CAST/EiJ	MGP_CASTEiJ_G0018529	protein coding gene	Chr11:104968943-104994799 (-)
CBA/J	MGP_CBAJ_G0018944	protein coding gene	Chr11:112860214-112885835 (-)
DBA/2J	MGP_DBA2J_G0019056	protein coding gene	Chr11:100199699-100223377 (-)
FVB/NJ	MGP_FVBNJ_G0019046	protein coding gene	Chr11:99728589-99751576 (-)
LP/J	MGP_LPJ_G0019125	protein coding gene	Chr11:105635989-105659749 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019077	protein coding gene	Chr11:112382699-112409143 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019653	protein coding gene	Chr11:104154513-104178509 (-)
PWK/PhJ	MGP_PWKPhJ_G0018292	protein coding gene	Chr11:101261574-101285404 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018084	protein coding gene	Chr11:103911245-103935212 (-)
WSB/EiJ	MGP_WSBEiJ_G0018578	protein coding gene	Chr11:104147500-104171232 (-)

Human Ortholog

LSM12, LSM12 homolog

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LSM12, LSM12 homolog
Synonyms

PNAS-135
Links

HGNC:26407

NCBI Gene ID: 124801

UniProt: Q3MHD2
Chr Location

17q21.31; chr17:44034328-44067619 (-) GRCh38

MGI Vertebrate Homology

Lsm12 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LSM12
Gene Tree

Lsm12

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

2
Gene trapped

7
Targeted

3
Genomic Mutations

1 involving Lsm12
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

Cellular Component

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

29
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lsm12

ZFIN lsm12b

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All Sequences

46
RefSeq

4
UniProt

2
CCDS

CCDS25490.1

Ensembl

ENSMUSG00000020922 (Evidence)
NCBI Gene

268490

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020922	Ensembl Gene Model \| MGI Sequence Detail	22800	C57BL/6J	± kb
transcript	ENSMUST00000021297	Ensembl \| MGI Sequence Detail	2256	Not Applicable
polypeptide	ENSMUSP00000021297	Ensembl \| MGI Sequence Detail	195	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009957 protein LSM12

(term hierarchy)
InterPro Domains

IPR047574 AD domain

IPR019181 LSM12, anticodon-binding domain

IPR048478 LSM12, LSM domain

IPR039683 Protein Lsm12-like

IPR047575 Sm domain

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All nucleic 29

cDNA 29

Microarray probesets 6

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MGI:1915991

Summaries

All 37

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 13
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Lsm12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111012	Chr11:102076065-102076142 (-)	18 bp
Tssr111011	Chr11:102076028-102076064 (-)	76 bp
Tssr111010	Chr11:102068544-102068547 (-)	7,576 bp
Tssr111009	Chr11:102058025-102058049 (-)	18,085 bp
Tssr111008	Chr11:102054841-102054887 (-)	21,258 bp
Tssr111007	Chr11:102054427-102054458 (-)	21,679 bp
Tssr111006	Chr11:102054379-102054383 (-)	21,741 bp
Tssr111005	Chr11:102053974-102053997 (-)	22,136 bp
Tssr111004	Chr11:102053472-102053476 (-)	22,648 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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