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Iars2 Gene Detail
Summary
  • Symbol
    Iars2
  • Name
    isoleucine-tRNA synthetase 2, mitochondrial
  • Synonyms
    2010002H18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919586
    NCBI Gene: 381314
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:185286642-185329419 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 89.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    456 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919586
protein coding gene Chr1:185284726-185329419 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016914
protein coding gene Chr1:192003848-192050892 (-)
A/J MGP_AJ_G0016893
protein coding gene Chr1:184160359-184204140 (-)
AKR/J MGP_AKRJ_G0016858
protein coding gene Chr1:189579601-189624036 (-)
BALB/cJ MGP_BALBcJ_G0016851
protein coding gene Chr1:184791292-184844044 (-)
C3H/HeJ MGP_C3HHeJ_G0016675
protein coding gene Chr1:190450504-190498123 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017314
protein coding gene Chr1:198139856-198187681 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015021
protein coding gene Chr1:175144156-175189040 (-)
CAST/EiJ MGP_CASTEiJ_G0016258
protein coding gene Chr1:189878681-189925572 (-)
CBA/J MGP_CBAJ_G0016649
protein coding gene Chr1:205531724-205583428 (-)
DBA/2J MGP_DBA2J_G0016755
protein coding gene Chr1:182921949-182964126 (-)
FVB/NJ MGP_FVBNJ_G0016751
protein coding gene Chr1:181017328-181060544 (-)
LP/J MGP_LPJ_G0016830
protein coding gene Chr1:193160305-193203854 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016783
protein coding gene Chr1:212407814-212454738 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017351
protein coding gene Chr1:189459402-189506735 (-)
PWK/PhJ MGP_PWKPhJ_G0016045
protein coding gene Chr1:182125873-182172455 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015821
protein coding gene Chr1:188414715-188456221 (-)
WSB/EiJ MGP_WSBEiJ_G0016320
protein coding gene Chr1:189626521-189670867 (-)



Homology
more
  • Human Ortholog
    IARS2, isoleucyl-tRNA synthetase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IARS2, isoleucyl-tRNA synthetase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAGSSS, ILERS
  • Links
    NCBI Gene ID: 55699
    neXtProt AC: NX_Q9NSE4
    UniProt: Q9NSE4

  • Chr Location
    1q41; chr1:220094113-220148041 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381314 NCBI Gene Model | MGI Sequence Detail 42778 C57BL/6J ±  kb
    transcript NM_198653 RefSeq | MGI Sequence Detail 3560 C57BL/6  
    polypeptide Q8BIJ6 UniProt | EBI | MGI Sequence Detail 1012 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008877 isoleucine--tRNA ligase, mitochondrial
    • EC
    • InterPro Domains
      IPR002300 Aminoacyl-tRNA synthetase, class Ia
      IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
      IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
      IPR002301 Isoleucine-tRNA ligase
      IPR023585 Isoleucine-tRNA ligase, type 1
      IPR033708 Isoleucyl tRNA synthetase type 1, anticodon-binding domain
      IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
      IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
      IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2138678
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/26/2019
    MGI 6.14
    The Jackson Laboratory