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Palld
Gene Detail
Symbol

Name
ID
Palld
palladin, cytoskeletal associated protein
MGI:1919583
Synonyms
2410003B16Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
31.23 cM, cytoband B3.3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:61513246-61902669 bp, - strand
From VEGA annotation of GRCm38

  389424 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75052  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PALLD
Gene Tree: Palld

Human
homologs
PALLD, palladin, cytoskeletal associated protein
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 23022
neXtProt AC: NX_Q8WX93

Human Synonyms: CGI151, CGI-151, MYN, PNCA1, SIH002

Human Chr (Location): 4q32.3; chr4:168497064-168928457 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PALLD

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
All homozygous null embryos die around E15.5 displaying exencephaly derived from neural tube closure defects, and herniation of the intestine and liver due to ventral closure defects. Mutant MEFs show impaired formation of actin stress fibers, reduced migration and decreased adhesion to fibronectin.
 
Interactions
Palld interacts with 39 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin cytoskeleton organization, epithelial cell morphogenesis, ...
Component actin cytoskeleton, actin filament, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (282)    Tissues (66)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 65
Western blot 7
RT-PCR 208
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PALLD ; Xenbase palld    NEW 
Molecular
reagents
All nucleic(30) cDNA(20) Primer pair(10)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000031055 (Evidence)
Ensembl Gene Model ENSMUSG00000058056 (Evidence)
Entrez Gene 72333 (Evidence)
DFCI TC1634111, TC1602715, TC1578828, TC1629891, TC1662197, TC1738712
DoTS DT.94165572, DT.94128528, DT.87027317, DT.488437, DT.101367627
NIA Mouse Gene Index U029865
PDB 2LQR
Consensus CDS Project CCDS40350.1
International Mouse Phenotyping Consortium Status Palld
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031055 VEGA Gene Model | MGI Sequence Detail 389424 C57BL/6J ±  kb
transcript OTTMUST00000076933 VEGA | MGI Sequence Detail 4536 Not Applicable 
polypeptide OTTMUSP00000040564 VEGA | MGI Sequence Detail 1408 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(21) UniProt(4)
Polymorphisms
SNPs within 2kb(2475 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000012248 palladin
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202029 Folgueras AR, et al., Architectural niche organization by LHX2 is linked to hair follicle stem cell function. Cell Stem Cell. 2013 Sep 5;13(3):314-27
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory