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Nkd2 Gene Detail
Summary
  • Symbol
    Nkd2
  • Name
    naked cuticle 2 homolog (Drosophila)
  • Synonyms
    2210403L10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919543
    NCBI Gene: 72293
Location & Maps
more
  • Sequence Map
    Chr13:73818534-73847631 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29098 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM, cytoband C1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NKD2, naked cuticle homolog 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NKD2, naked cuticle homolog 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Naked2
  • Links
    NCBI Gene ID: 85409
    neXtProt AC: NX_Q969F2

  • Chr Location
    5p15.3; chr5:1008820-1038812 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Chemically induced (other)
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Nkd2
  • Incidental Mutations
Mice homozygous for a reporter allele are viable and fertile but show a slight and background-sensitive reduction in average litter size relative to control mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027729 VEGA Gene Model | MGI Sequence Detail 29098 C57BL/6J ±  kb
transcript OTTMUST00000068619 VEGA | MGI Sequence Detail 4016 Not Applicable  
polypeptide OTTMUSP00000034735 VEGA | MGI Sequence Detail 461 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    207 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 17
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:2145424
References
more
  • Summaries
    All 39
    Developmental Gene Expression 13
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228507 Ajima R, et al., DAAM1 and DAAM2 are co-required for myocardial maturation and sarcomere assembly. Dev Biol. 2015 Dec 1;408(1):126-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory