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Nkd2 Gene Detail
Summary
  • Symbol
    Nkd2
  • Name
    naked cuticle 2
  • Synonyms
    2210403L10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919543
    NCBI Gene: 72293
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73818534-73847631 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 40.15 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919543
protein coding gene Chr13:73818529-73847631 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020752
protein coding gene Chr13:74300780-74329762 (-)
A/J MGP_AJ_G0020708
protein coding gene Chr13:71643231-71672339 (-)
AKR/J MGP_AKRJ_G0020682
protein coding gene Chr13:73896240-73925265 (-)
BALB/cJ MGP_BALBcJ_G0020705
protein coding gene Chr13:72133096-72164387 (-)
C3H/HeJ MGP_C3HHeJ_G0020499
protein coding gene Chr13:73575086-73604844 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021142
protein coding gene Chr13:76762394-76792622 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018709
protein coding gene Chr13:68471378-68498604 (-)
CAST/EiJ MGP_CASTEiJ_G0020016
protein coding gene Chr13:72651609-72678840 (-)
CBA/J MGP_CBAJ_G0020458
protein coding gene Chr13:79613434-79645517 (-)
DBA/2J MGP_DBA2J_G0020583
protein coding gene Chr13:71462582-71492851 (-)
FVB/NJ MGP_FVBNJ_G0020563
protein coding gene Chr13:70487280-70516388 (-)
LP/J MGP_LPJ_G0020656
protein coding gene Chr13:74538425-74567392 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020591
protein coding gene Chr13:78044264-78074223 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021181
protein coding gene Chr13:73202463-73232187 (-)
PWK/PhJ MGP_PWKPhJ_G0019770
protein coding gene Chr13:70203463-70233042 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019593
protein coding gene Chr13:69674467-69706236 (-)
WSB/EiJ MGP_WSBEiJ_G0020074
protein coding gene Chr13:73756779-73788300 (-)



Homology
more
  • Human Ortholog
    NKD2, NKD inhibitor of WNT signaling pathway 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NKD2, NKD inhibitor of WNT signaling pathway 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Naked2
  • Links
    NCBI Gene ID: 85409
    neXtProt AC: NX_Q969F2
    UniProt: Q969F2

  • Chr Location
    5p15.33; chr5:1008845-1038812 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele are viable and fertile but show a slight and background-sensitive reduction in average litter size relative to control mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021567 Ensembl Gene Model | MGI Sequence Detail 29098 C57BL/6J ±  kb
transcript ENSMUST00000022051 Ensembl | MGI Sequence Detail 4016 Not Applicable  
polypeptide ENSMUSP00000022051 Ensembl | MGI Sequence Detail 461 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 19
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2145424
References
more
  • Summaries
    All 46
    Developmental Gene Expression 15
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:248185 Pan X, et al., Myc cooperates with beta-catenin to drive gene expression in nephron progenitor cells. Development. 2017 Nov 15;144(22):4173-4182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory