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Sh2d4a Gene Detail
Summary
  • Symbol
    Sh2d4a
  • Name
    SH2 domain containing 4A
  • Synonyms
    2210402M20Rik, SH2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919531
    NCBI Gene: 72281
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:68729219-68800351 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 33.76 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    705 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919531
 protein coding gene Chr8:68729180-68800356 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033660
 protein coding gene Chr8:68407009-68481642 (+)
A/J MGP_AJ_G0033642
 protein coding gene Chr8:65634845-65703513 (+)
AKR/J MGP_AKRJ_G0033567
 protein coding gene Chr8:67424018-67506182 (+)
BALB/cJ MGP_BALBcJ_G0033638
 protein coding gene Chr8:65830595-65900625 (+)
C3H/HeJ MGP_C3HHeJ_G0033348
 protein coding gene Chr8:68156137-68227030 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034155
 protein coding gene Chr8:70959229-71042411 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031102
 protein coding gene Chr8:60549754-60618869 (+)
CAST/EiJ MGP_CASTEiJ_G0032673
 protein coding gene Chr8:67597422-67667548 (+)
CBA/J MGP_CBAJ_G0033326
 protein coding gene Chr8:73643384-73732738 (+)
DBA/2J MGP_DBA2J_G0033480
 protein coding gene Chr8:65359480-65433584 (+)
FVB/NJ MGP_FVBNJ_G0033421
 protein coding gene Chr8:64521922-64591520 (+)
LP/J MGP_LPJ_G0033568
 protein coding gene Chr8:68488719-68565386 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033465
 protein coding gene Chr8:76293978-76384094 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034173
 protein coding gene Chr8:67701885-67771639 (+)
PWK/PhJ MGP_PWKPhJ_G0032382
 protein coding gene Chr8:64604716-64678415 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032218
 protein coding gene Chr8:66629170-66706845 (+)
WSB/EiJ MGP_WSBEiJ_G0032790
 protein coding gene Chr8:68073087-68142874 (+)



Homology
more
  • Human Ortholog
    SH2D4A, SH2 domain containing 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH2D4A, SH2 domain containing 4A
  • Synonyms
    PPP1R38, SH2A
  • Links
    NCBI Gene ID: 63898
    neXtProt AC: NX_Q9H788
    UniProt: Q9H788

  • Chr Location
    8p21.3; chr8:19313693-19396218 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Mice homozygous for a knock-out allele display normal T cell development, homeostasis, proliferation, and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    12
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053886 Ensembl Gene Model | MGI Sequence Detail 71133 C57BL/6J ±  kb
transcript ENSMUST00000066594 Ensembl | MGI Sequence Detail 2718 Not Applicable  
polypeptide ENSMUSP00000070825 Ensembl | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory