Dnajc24 MGI Mouse Gene Detail - MGI:1919522 - DnaJ heat shock protein family (Hsp40) member C24

Symbol

Dnajc24
Name

DnaJ heat shock protein family (Hsp40) member C24
Synonyms

1700030A21Rik, 2610027M02Rik, Dph4, MmDjC7, Zcsl3

Feature Type

protein coding gene
IDs

MGI:1919522
NCBI Gene: 99349
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:105797054-105833894 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 55.46 cM, cytoband E3
Mapping Data

4 experiments

SNPs within 2kb

74 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919522	protein coding gene	Chr2:105797053-105833894 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026233	protein coding gene	Chr2:108147430-108190605 (-)
A/J	MGP_AJ_G0026194	protein coding gene	Chr2:103640422-103682038 (-)
AKR/J	MGP_AKRJ_G0026174	protein coding gene	Chr2:106479395-106517324 (-)
BALB/cJ	MGP_BALBcJ_G0026203	protein coding gene	Chr2:103917121-103954218 (-)
C3H/HeJ	MGP_C3HHeJ_G0025953	protein coding gene	Chr2:106759698-106813609 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026654	protein coding gene	Chr2:111660649-111700454 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024040	protein coding gene	Chr2:99430077-99470153 (-)
CAST/EiJ	MGP_CASTEiJ_G0025418	protein coding gene	Chr2:107296416-107334639 (-)
CBA/J	MGP_CBAJ_G0025931	protein coding gene	Chr2:115553796-115593828 (-)
DBA/2J	MGP_DBA2J_G0026069	protein coding gene	Chr2:103195038-103233870 (-)
FVB/NJ	MGP_FVBNJ_G0026032	protein coding gene	Chr2:102159360-102197923 (-)
LP/J	MGP_LPJ_G0026172	protein coding gene	Chr2:108313740-108353384 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026056	protein coding gene	Chr2:119395004-119432727 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026708	protein coding gene	Chr2:106656803-106698415 (-)
PWK/PhJ	MGP_PWKPhJ_G0025153	protein coding gene	Chr2:102710710-102754923 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024953	protein coding gene	Chr2:105901403-105941937 (-)
WSB/EiJ	MGP_WSBEiJ_G0025485	protein coding gene	Chr2:107392629-107431712 (-)

Human Ortholog

DNAJC24, DnaJ heat shock protein family (Hsp40) member C24

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJC24, DnaJ heat shock protein family (Hsp40) member C24
Synonyms

DPH4, JJJ3, ZCSL3
Links

HGNC:26979

NCBI Gene ID: 120526

neXtProt AC: NX_Q6P3W2

UniProt: Q6P3W2
Chr Location

11p13; chr11:31369840-31432835 (+) GRCh38

MGI Vertebrate Homology

Dnajc24 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJC24
Gene Tree

Dnajc24

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Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

14
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Dnajc24
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced mutation are retarded in growth and development, and generally die before birth; those that survive long enough to initiate digit formation show a distinctive polydactyly phenotype on their hind limbs.

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All GO Annotations

14
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

8
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajc24

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All Sequences

44
RefSeq

3
UniProt

2
CCDS

CCDS16501.1

Ensembl

ENSMUSG00000027166 (Evidence)
NCBI Gene

99349

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027166	Ensembl Gene Model \| MGI Sequence Detail	36841	C57BL/6J	± kb
transcript	ENSMUST00000102555	Ensembl \| MGI Sequence Detail	1197	Not Applicable
polypeptide	ENSMUSP00000099615	Ensembl \| MGI Sequence Detail	148	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006585 DnaJ homolog subfamily C member 24

(term hierarchy)
PDB

1WJZ
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR042978 DnaJ homolog subfamily C member 24

IPR007872 DPH-type metal-binding domain

IPR036671 DPH-type metal-binding domain superfamily

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All nucleic 9

cDNA 9

Microarray probesets 4

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MGI:1916468, MGI:2139244, MGI:2139332

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Dnajc24:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr25569	Chr2:105833526-105833622 (-)	320 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23