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Lrrc8e Gene Detail
Summary
  • Symbol
    Lrrc8e
  • Name
    leucine rich repeat containing 8 family, member E
  • Synonyms
    1810049O03Rik, C87354
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919517
    NCBI Gene: 72267
  • Gene Overview
    MyGene.info: LRRC8E
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:4226827-4237470 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 1.99 cM, cytoband A1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919517
protein coding gene Chr8:4224269-4237470 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033327
protein coding gene Chr8:1212494-1222893 (+)
A/J MGP_AJ_G0033308
protein coding gene Chr8:1161546-1172155 (+)
AKR/J MGP_AKRJ_G0033239
protein coding gene Chr8:1197022-1207359 (+)
BALB/cJ MGP_BALBcJ_G0033308
protein coding gene Chr8:1214991-1225242 (+)
C3H/HeJ MGP_C3HHeJ_G0033022
protein coding gene Chr8:1205978-1217220 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033820
protein coding gene Chr8:1251752-1262103 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030792
protein coding gene Chr8:1034589-1046548 (+)
CAST/EiJ MGP_CASTEiJ_G0032346
protein coding gene Chr8:1090562-1101025 (+)
CBA/J MGP_CBAJ_G0032995
protein coding gene Chr8:1288235-1301383 (+)
DBA/2J MGP_DBA2J_G0033149
protein coding gene Chr8:1121811-1132431 (+)
FVB/NJ MGP_FVBNJ_G0033096
protein coding gene Chr8:1154227-1169892 (+)
LP/J MGP_LPJ_G0033243
protein coding gene Chr8:1128152-1142993 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033131
protein coding gene Chr8:1258468-1276631 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033837
protein coding gene Chr8:1179719-1190992 (+)
PWK/PhJ MGP_PWKPhJ_G0032057
protein coding gene Chr8:1086340-1097016 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031900
protein coding gene Chr8:1100215-1112177 (+)
WSB/EiJ MGP_WSBEiJ_G0032460
protein coding gene Chr8:1160139-1170528 (+)



Homology
more
  • Human Ortholog
    LRRC8E, leucine rich repeat containing 8 VRAC subunit E
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LRRC8E, leucine rich repeat containing 8 VRAC subunit E
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 80131
    neXtProt AC: NX_Q6NSJ5
    UniProt: Q6NSJ5

  • Chr Location
    19p13.2; chr19:7888505-7902023 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046589 Ensembl Gene Model | MGI Sequence Detail 10644 C57BL/6J ±  kb
transcript ENSMUST00000053035 Ensembl | MGI Sequence Detail 3878 Not Applicable  
polypeptide ENSMUSP00000052055 Ensembl | MGI Sequence Detail 795 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142883
References
more
  • Summaries
    All 26
    Gene Ontology 5
    Phenotypes 1
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory