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Otud6b Gene Detail
Summary
  • Symbol
    Otud6b
  • Name
    OTU domain containing 6B
  • Synonyms
    2600013N14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919451
    NCBI Gene: 72201
  • Gene Overview
    MyGene.info: OTUD6B
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:14809505-14826587 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 6.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919451
protein coding gene Chr4:14809498-14826587 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028068
protein coding gene Chr4:11618224-11633194 (-)
A/J MGP_AJ_G0028026
protein coding gene Chr4:11361372-11380237 (-)
AKR/J MGP_AKRJ_G0027991
protein coding gene Chr4:11528510-11544645 (-)
BALB/cJ MGP_BALBcJ_G0028037
protein coding gene Chr4:11261928-11277909 (-)
C3H/HeJ MGP_C3HHeJ_G0027767
protein coding gene Chr4:11678826-11699165 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0025822
protein coding gene Chr4:10608656-10624577 (-)
CAST/EiJ MGP_CASTEiJ_G0027222
protein coding gene Chr4:11483979-11500995 (-)
CBA/J MGP_CBAJ_G0027740
protein coding gene Chr4:12383181-12408341 (-)
DBA/2J MGP_DBA2J_G0027883
protein coding gene Chr4:11210372-11229887 (-)
FVB/NJ MGP_FVBNJ_G0027849
protein coding gene Chr4:10994839-11013551 (-)
LP/J MGP_LPJ_G0027992
protein coding gene Chr4:11725171-11750796 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027882
protein coding gene Chr4:12740907-12765536 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0026942
protein coding gene Chr4:11166093-11182041 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026771
protein coding gene Chr4:11421614-11439095 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    OTUD6B, OTU domain containing 6B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OTUD6B, OTU domain containing 6B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CGI-77, DUBA5, DUBA-5, IDDFSDA
  • Links
    NCBI Gene ID: 51633
    neXtProt AC: NX_Q8N6M0
    UniProt: Q8N6M0

  • Chr Location
    8q21.3; chr8:91070196-91087095 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6064
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OTUD6B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete perinatal lethality, decreased fetal size, and ventricular septal defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72201 NCBI Gene Model | MGI Sequence Detail 17083 C57BL/6J ±  kb
    transcript NM_152812 RefSeq | MGI Sequence Detail 3085 C57BL/6  
    polypeptide Q8K2H2 UniProt | EBI | MGI Sequence Detail 294 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 127
      cDNA 127

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140427
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:240669 Santiago-Sim T, et al., Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features. Am J Hum Genet. 2017 Apr 06;100(4):676-688

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory