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Fbxl20
Gene Detail
Symbol

Name
ID
Fbxl20
F-box and leucine-rich repeat protein 20
MGI:1919444
Synonyms
2610511F20Rik, 4632423N09Rik, C86145, Fbl2, Scr, Scrapper
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:98082556-98150403 bp, - strand
From VEGA annotation of GRCm38

  67848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68784  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FBXL20
Protein SuperFamily: conserved protein with F-box/LRR-repeat, Skp2 type
Gene Tree: Fbxl20

Human
homologs
FBXL20, F-box and leucine-rich repeat protein 20
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 84961
neXtProt AC: NX_Q96IG2

Human Synonyms: Fbl2, Fbl20

Human Chr (Location): 17q12; chr17:39252644-39402661 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(21) Targeted(4)
Genomic Mutations involving Fbxl20 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit some embryonic lethality, shortened lifespans, decreased body size and altered CNS synaptic transmission.
 
Interactions
Fbxl20 interacts with 471 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process behavioral fear response
Component cytoplasm
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (36)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 36
cDNA source data(148)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fbxl20    NEW 
Molecular
reagents
All nucleic(150) cDNA(149) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000002913 (Evidence)
Ensembl Gene Model ENSMUSG00000020883 (Evidence)
Entrez Gene 72194 (Evidence)
UniGene 218350
DFCI TC1635025, TC1578037, TC1614999, TC1583448, TC1601225, TC1684603
DoTS DT.55122433, DT.103574098, DT.40170240
NIA Mouse Gene Index U013286
Consensus CDS Project CCDS25339.1
International Mouse Phenotyping Consortium Status Fbxl20
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002913 VEGA Gene Model | MGI Sequence Detail 67848 C57BL/6J ±  kb
transcript OTTMUST00000005970 VEGA | MGI Sequence Detail 8601 Not Applicable 
polypeptide OTTMUSP00000002821 VEGA | MGI Sequence Detail 436 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(509 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001810 F-box domain, cyclin-like
InterPro IPR006553 Leucine-rich repeat, cysteine-containing subtype
Protein Ontology PR:000007379 F-box/LRR-repeat protein 20
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(39)
Other
accession IDs
MGI:2144301, MGI:2144684, MGI:3034930

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory