Fbxl20
Gene Detail

Symbol Name ID

Fbxl20 F-box and leucine-rich repeat protein 20 MGI:1919444

Synonyms

2610511F20Rik, 4632423N09Rik, C86145, Fbl2, Scr, Scrapper

Feature Type

protein coding gene

Genetic Map

Chromosome 11

61.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:98082556-98150403 bp, - strand From VEGA annotation of GRCm38   67848 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68784  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: conserved protein with F-box/LRR-repeat, Skp2 type
Gene Tree: Fbxl20

Human homologs

Human Homolog		FBXL20, F-box and leucine-rich repeat protein 20
NCBI Gene ID		84961
neXtProt AC		NX_Q96IG2
Human Synonyms		Fbl2, Fbl20
Human Chr (Location)		17q12; chr17:37408897-37557909 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(24) : Targeted(3) Gene trapped(21)
 

Mice homozygous for a null allele exhibit some embryonic lethality, shortened lifespans, decreased body size and altered CNS synaptic transmission.

 

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	biological_process
Component	cytoplasm
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (36)    Tissues (2)   
Theiler Stages: 2, 3

Assay Type	Results
RT-PCR	36

cDNA source data(149)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(151) cDNA(150) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000002913 (Evidence)
Ensembl Gene Model	ENSMUSG00000020883 (Evidence)
Entrez Gene	72194 (Evidence)
UniGene	218350
DFCI	TC1578037, TC1583448, TC1601225, TC1614999, TC1635025, TC1684603
DoTS	DT.103574098, DT.40170240, DT.55122433
NIA Mouse Gene Index	U013286
Consensus CDS Project	CCDS25339.1
International Mouse Knockout Project Status	Fbxl20

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002913	VEGA Gene Model | MGI Sequence Detail	67848	C57BL/6J
transcript	OTTMUST00000005970	VEGA | MGI Sequence Detail	8601	Not Applicable
polypeptide	OTTMUSP00000002821	VEGA | MGI Sequence Detail	436	Not Applicable

All sequences(62) RefSeq(3) UniProt(4)

Polymorphisms

SNPs(334 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001810	F-box domain, cyclin-like
InterPro	IPR006553	Leucine-rich repeat, cysteine-containing subtype
Protein Ontology	PR:000007379	F-box/LRR-repeat protein 20

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(41)

Other accession IDs

MGI:2144301, MGI:2144684, MGI:3034930