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Fbxl20 Gene Detail
Summary
  • Symbol
    Fbxl20
  • Name
    F-box and leucine-rich repeat protein 20
  • Synonyms
    2610511F20Rik, 4632423N09Rik, C86145, Fbl2, Scr, Scrapper
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919444
    NCBI Gene: 72194
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:98082556-98150403 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67848 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FBXL20, F-box and leucine rich repeat protein 20
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FBXL20, F-box and leucine rich repeat protein 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Fbl2, Fbl20
  • Links
    NCBI Gene ID: 84961
    neXtProt AC: NX_Q96IG2
    UniProt: Q96IG2

  • Chr Location
    17q12; chr17:39252644-39402659 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit some embryonic lethality, shortened lifespans, decreased body size and altered CNS synaptic transmission.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000002913 VEGA Gene Model | MGI Sequence Detail 67848 C57BL/6J ±  kb
    transcript OTTMUST00000005970 VEGA | MGI Sequence Detail 8601 Not Applicable  
    polypeptide OTTMUSP00000002821 VEGA | MGI Sequence Detail 436 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      508 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR001810 F-box domain
      IPR036047 F-box-like domain superfamily
      IPR001611 Leucine-rich repeat
      IPR006553 Leucine-rich repeat, cysteine-containing subtype
      IPR032675 Leucine-rich repeat domain superfamily
    Molecular
    Reagents
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    • All nucleic 152
      cDNA 151
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144301, MGI:2144684, MGI:3034930
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:240596 Koga K, et al., SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex. J Neurosci. 2017 Apr 05;37(14):3887-3895

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory