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Fbxl20 Gene Detail
Summary
  • Symbol
    Fbxl20
  • Name
    F-box and leucine-rich repeat protein 20
  • Synonyms
    2610511F20Rik, 4632423N09Rik, C86145, Fbl2, Scr, Scrapper
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919444
    NCBI Gene: 72194
Location & Maps
more
  • Sequence Map
    Chr11:98082556-98150403 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67848 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.69 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FBXL20, F-box and leucine rich repeat protein 20
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FBXL20, F-box and leucine rich repeat protein 20
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Fbl2, Fbl20
  • Links
    NCBI Gene ID: 84961
    neXtProt AC: NX_Q96IG2

  • Chr Location
    17q12; chr17:39252644-39402661 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Gene trapped
    21
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Fbxl20
  • Incidental Mutations
Mice homozygous for a null allele exhibit some embryonic lethality, shortened lifespans, decreased body size and altered CNS synaptic transmission.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002913 VEGA Gene Model | MGI Sequence Detail 67848 C57BL/6J ±  kb
transcript OTTMUST00000005970 VEGA | MGI Sequence Detail 8601 Not Applicable  
polypeptide OTTMUSP00000002821 VEGA | MGI Sequence Detail 436 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    508 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007379 F-box/LRR-repeat protein 20
  • InterPro Domains
    IPR001810 F-box domain
    IPR001611 Leucine-rich repeat
    IPR006553 Leucine-rich repeat, cysteine-containing subtype
    IPR032675 Leucine-rich repeat domain, L domain-like
Molecular
Reagents
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  • All nucleic 150
    cDNA 149
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2144301, MGI:2144684, MGI:3034930
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory