Scaf11 MGI Mouse Gene Detail - MGI:1919443 - SR-related CTD-associated factor 11

Symbol

Scaf11
Name

SR-related CTD-associated factor 11
Synonyms

1110061H03Rik, 2610510E10Rik, CASP11, Sfrs2ip, SIP1, SRRP129, Srsf2ip

Feature Type

protein coding gene
IDs

MGI:1919443
NCBI Gene: 72193
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:96309580-96358724 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 52.44 cM
Mapping Data

2 experiments

SNPs within 2kb

143 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919443	protein coding gene	Chr15:96309579-96358886 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022269	protein coding gene	Chr15:97996725-98048051 (-)
A/J	MGP_AJ_G0022228	protein coding gene	Chr15:94160936-94209723 (-)
AKR/J	MGP_AKRJ_G0022203	protein coding gene	Chr15:96985942-97036040 (-)
BALB/cJ	MGP_BALBcJ_G0022234	protein coding gene	Chr15:94358415-94408324 (-)
C3H/HeJ	MGP_C3HHeJ_G0022004	protein coding gene	Chr15:97040031-97088963 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022679	protein coding gene	Chr15:101624660-101675962 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020205	protein coding gene	Chr15:90157606-90209081 (-)
CAST/EiJ	MGP_CASTEiJ_G0021526	protein coding gene	Chr15:97904183-97954820 (-)
CBA/J	MGP_CBAJ_G0021971	protein coding gene	Chr15:105004244-105058125 (-)
DBA/2J	MGP_DBA2J_G0022098	protein coding gene	Chr15:93605482-93654274 (-)
FVB/NJ	MGP_FVBNJ_G0022077	protein coding gene	Chr15:92590150-92639899 (-)
LP/J	MGP_LPJ_G0022169	protein coding gene	Chr15:98119581-98168413 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022097	protein coding gene	Chr15:109216124-109274426 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022694	protein coding gene	Chr15:97117441-97167660 (-)
PWK/PhJ	MGP_PWKPhJ_G0021267	protein coding gene	Chr15:93681249-93730680 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021101	protein coding gene	Chr15:96911498-96963808 (-)
WSB/EiJ	MGP_WSBEiJ_G0021575	protein coding gene	Chr15:97631395-97682429 (-)

Human Ortholog

SCAF11, SR-related CTD associated factor 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCAF11, SR-related CTD associated factor 11
Synonyms

CASP11, SFRS2IP, SIP1, SRRP129, SRSF2IP
Links

HGNC:10784

NCBI Gene ID: 9169

neXtProt AC: NX_Q99590

UniProt: Q99590
Chr Location

12q12; chr12:45919131-45992040 (-) GRCh38.p7

Alliance of Genome Resources

Scaf11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCAF11
Gene Tree

Scaf11

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

50
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

43
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Scaf11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

4
cDNA Data

15
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scaf11

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Scaf11 interacts with 339 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

68
RefSeq

8
UniProt

8
CCDS

CCDS37186.1

Ensembl

ENSMUSG00000033228 (Evidence)
NCBI Gene

72193

			Length	Strain/Species	Flank
genomic	ENSMUSG00000033228	Ensembl Gene Model \| MGI Sequence Detail	49145	C57BL/6J	± kb
transcript	ENSMUST00000047835	Ensembl \| MGI Sequence Detail	5766	Not Applicable
polypeptide	ENSMUSP00000044898	Ensembl \| MGI Sequence Detail	1456	Not Applicable

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UniProt

8 Sequences
InterPro Domains

IPR027370 RING-type zinc-finger, LisH dimerisation motif

IPR018957 Zinc finger, C3HC4 RING-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 15

cDNA 15

Microarray probesets 8

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MGI:1916069, MGI:2146022

Summaries

All 57

Developmental Gene Expression 3

Diseases 1

Gene Ontology 2

Phenotypes 32
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:301232 Butterfield NC, et al., Accelerating functional gene discovery in osteoarthritis. Nat Commun. 2021 Jan 20;12(1):467

TSS for Scaf11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136028	Chr15:96358816-96358874 (-)	-121 bp
Tssr136027	Chr15:96358752-96358807 (-)	-56 bp
Tssr136026	Chr15:96358719-96358737 (-)	-4 bp
Tssr136025	Chr15:96358624-96358715 (-)	54 bp
Tssr136024	Chr15:96358592-96358623 (-)	116 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/28/2022 MGI 6.20