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Mfsd8
Gene Detail
 Symbol
Name
ID
Mfsd8
major facilitator superfamily domain containing 8
MGI:1919425
Synonyms 2810423E13Rik, Cln7
Feature Type protein coding gene
Genetic Map
Chromosome 3
19.55 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:40818070-40846885 bp, - strand
From VEGA annotation of GRCm38

  28816 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:115814  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mfsd8

Human
homologs
Human Homolog MFSD8, major facilitator superfamily domain containing 8
NCBI Gene ID 256471
neXtProt AC  NX_Q8NHS3
Human Synonyms  CLN7
Human Chr (Location)  4q28.2; chr4:127917805-127965984 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MFSD8
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(3) Targeted(3)
Interactions
Mfsd8 interacts with 265 markers (Mir1a-1, Mir1a-2, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process lysosome organization, transmembrane transport, ...
Component integral component of membrane, intracellular membrane-bounded organelle, ...
Function molecular_function
External Resources: FuncBase
Expression
cDNA source data(37)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(37)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027548 (Evidence)
Ensembl Gene ModelENSMUSG00000025759 (Evidence)
Entrez Gene72175 (Evidence)
UniGene130610
NIA Mouse Gene IndexU023973
Consensus CDS ProjectCCDS17329.1
International Mouse Knockout Project StatusMfsd8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027548 VEGA Gene Model | MGI Sequence Detail 28816 C57BL/6J ±  kb
transcript OTTMUST00000068214 VEGA | MGI Sequence Detail 3184 Not Applicable 
polypeptide OTTMUSP00000034429 VEGA | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(140 from dbSNP Build 137)    SNPs within 2kb including multiple locations(188)
Protein-related
information
ResourceIDDescription
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000010375 major facilitator superfamily domain-containing protein 8
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211608 Damme M, et al., Gene disruption of Mfsd8 in mice provides the first animal model for CLN7 disease. Neurobiol Dis. 2014 May;65:12-24
All references(34)
Other
accession IDs
MGI:2139801, MGI:3035426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory