Rexo5 MGI Mouse Gene Detail - MGI:1919402

Symbol

Rexo5
Name

RNA exonuclease 5
Synonyms

2610020H08Rik

Feature Type

protein coding gene
IDs

MGI:1919402
NCBI Gene: 434234
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:119393229-119448166 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 64.21 cM, cytoband F3
Mapping Data

2 experiments

SNPs within 2kb

1114 from dbSNP Build 142
Strain Annotations

27

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919402	protein coding gene	Chr7:119393229-119488130 (+)
129S1/SvImJ	ENSMUSGG00200054752	protein coding gene	Chr7:105913483-105924651 (+)
129S1/SvImJ	ENSMUSG00200021671	protein coding gene	Chr7:105924508-105968308 (+)
A/J	ENSMUSGG00195055349	protein coding gene	Chr7:110429023-110440156 (+)
A/J	ENSMUSG00195033085	protein coding gene	Chr7:110440013-110483801 (+)
AKR/J	ENSMUSG00220022083	protein coding gene	Chr7:103885157-103928955 (+)
AKR/J	ENSMUSGG00220054838	protein coding gene	Chr7:103874137-103885300 (+)
BALB/cJ	ENSMUSGG00180055092	protein coding gene	Chr7:107092253-107103387 (+)
BALB/cJ	ENSMUSG00180027712	protein coding gene	Chr7:107103244-107147030 (+)
C3H/HeJ	ENSMUSGG00175055108	protein coding gene	Chr7:107805774-107816915 (+)
C3H/HeJ	ENSMUSG00175022008	protein coding gene	Chr7:107816772-107860559 (+)
C57BL/6NJ	ENSMUSGG00215055191	protein coding gene	Chr7:107068667-107079838 (+)
C57BL/6NJ	ENSMUSG00215016326	protein coding gene	Chr7:107079695-107123496 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030385	protein coding gene	Chr7:121959424-122011091 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSGG00210055043	protein coding gene	Chr7:107528275-107539415 (+)
CBA/J	ENSMUSG00210022784	protein coding gene	Chr7:107539272-107583056 (+)
DBA/2J	ENSMUSG00185043661	protein coding gene	Chr7:111890276-111934061 (+)
DBA/2J	ENSMUSGG00185057898	protein coding gene	Chr7:111879286-111890419 (+)
FVB/NJ	ENSMUSGG00205054233	protein coding gene	Chr7:107530948-107542104 (+)
FVB/NJ	ENSMUSG00205025407	protein coding gene	Chr7:107541961-107585760 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230035254	protein coding gene	Chr7:118011245-118055042 (+)
LP/J	ENSMUSGG00230055452	protein coding gene	Chr7:118000225-118011388 (+)
NOD/ShiLtJ	ENSMUSGG00190054730	protein coding gene	Chr7:107744829-107756000 (+)
NOD/ShiLtJ	ENSMUSG00190021244	protein coding gene	Chr7:107755857-107799659 (+)
NZO/HlLtJ	ENSMUSG00225039140	protein coding gene	Chr7:116246804-116290588 (+)
NZO/HlLtJ	ENSMUSGG00225055290	protein coding gene	Chr7:116235818-116246947 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010006569	protein coding gene	Chr7:107295304-107349524 (+)
WSB/EiJ	no annotation

Human Ortholog

REXO5, RNA exonuclease 5

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REXO5, RNA exonuclease 5
Synonyms

NEF-sp
Links

HGNC:24661

NCBI Gene ID: 81691

UniProt: Q96IC2
Chr Location

16p12.3; chr16:20806157-20849668 (+) GRCh38

MGI Vertebrate Homology

Rexo5 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: REXO5
Gene Tree

Rexo5

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Phenotype Summary

1 phenotype from multigenic genotypes
7 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available

Mice homozygous for a knock-out allele exhibit normal fertility.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

619
Tissues

22
cDNA Data

22
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rexo5

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All Sequences

120
RefSeq

58
UniProt

9
CCDS

CCDS21787.1, CCDS21788.1

Ensembl

ENSMUSG00000030924 (Evidence)
NCBI Gene

434234

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030924	Ensembl Gene Model \| MGI Sequence Detail	54938	C57BL/6J	± kb
transcript	ENSMUST00000106520	Ensembl \| MGI Sequence Detail	2492	Not Applicable
polypeptide	ENSMUSP00000102130	Ensembl \| MGI Sequence Detail	759	Not Applicable

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UniProt

9 Sequences
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR013520 Ribonuclease H-like domain

IPR012337 Ribonuclease H-like superfamily

IPR036397 Ribonuclease H superfamily

IPR035979 RNA-binding domain superfamily

IPR034922 RNA exonuclease 1-like, exonuclease domain

IPR047021 RNA exonuclease REXO1/REXO3/REXO4-like

IPR000504 RNA recognition motif domain

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 4

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MGI:5883131

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:243740 Silva S, et al., Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' --> 5' exoribonuclease. RNA. 2017 Sep;23(9):1385-1392

TSS for Rexo5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68757	Chr7:119392964-119392975 (+)	-259 bp
Tssr68758	Chr7:119393210-119393235 (+)	-6 bp
Tssr68759	Chr7:119393244-119393268 (+)	27 bp
Tssr68760	Chr7:119393325-119393380 (+)	124 bp
Tssr68761	Chr7:119393491-119393517 (+)	275 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29