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Rfc5 Gene Detail
Summary
  • Symbol
    Rfc5
  • Name
    replication factor C (activator 1) 5
  • Synonyms
    2610020K06Rik, 2610209F07Rik, 36.5kDa, 36kDa, Recc5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919401
    NCBI Gene: 72151
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:117517210-117527088 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.88 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919401
 protein coding gene Chr5:117516168-117527112 (-)
129S1/SvImJ ENSMUSG00200020831
 protein coding gene Chr5:111264701-111275652 (-)
A/J ENSMUSG00195035374
 protein coding gene Chr5:110778267-110789216 (-)
AKR/J ENSMUSG00220044339
 protein coding gene Chr5:110279039-110289988 (-)
BALB/cJ ENSMUSG00180045694
 protein coding gene Chr5:110900060-110911009 (-)
C3H/HeJ ENSMUSG00175021169
 protein coding gene Chr5:112896436-112907379 (-)
C57BL/6NJ ENSMUSG00215028118
 protein coding gene Chr5:110919087-110930031 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027644
 protein coding gene Chr5:110322004-110332841 (-)
CAST/EiJ ENSTCUG00005021854
 protein coding gene Chr5:110089496-110100431 (-)
CBA/J ENSMUSG00210007291
 protein coding gene Chr5:111647494-111658437 (-)
DBA/2J ENSMUSG00185043537
 protein coding gene Chr5:114710734-114721661 (-)
FVB/NJ ENSMUSG00205022725
 protein coding gene Chr5:110554419-110565363 (-)
JF1/MsJ ENSUMUG00000040130
 protein coding gene Chr5:117535830-117546807 (-)
LP/J ENSMUSG00230042190
 protein coding gene Chr5:118787225-118798174 (-)
NOD/ShiLtJ ENSMUSG00190031321
 protein coding gene Chr5:110587223-110598167 (-)
NZO/HlLtJ ENSMUSG00225013697
 protein coding gene Chr5:126460062-126470989 (-)
PWK/PhJ ENSLUMG00010028124
 protein coding gene Chr5:109427287-109438241 (-)
SPRET/EiJ ENSMSPG00010032066
 protein coding gene Chr5:112737715-112747517 (-)
WSB/EiJ ENSIUOG00005015368
 protein coding gene Chr5:113276050-113286993 (-)



Homology
more
  • Human Ortholog
    RFC5, replication factor C subunit 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RFC5, replication factor C subunit 5
  • Synonyms
    RFC36
  • Links
    NCBI Gene ID: 5985
    UniProt: P40937

  • Chr Location
    12q24.23; chr12:118013588-118041448 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    84
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 72151 NCBI Gene Model | MGI Sequence Detail 9879 C57BL/6J ±  kb
    transcript NM_028128 RefSeq | MGI Sequence Detail 1750 C57BL/6  
    polypeptide Q9D0F6 UniProt | EBI | MGI Sequence Detail 339 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013909 replication factor C subunit 5
      (term hierarchy)
    • InterPro Domains
      IPR003593 AAA+ ATPase domain
      IPR003959 ATPase, AAA-type, core
      IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal
      IPR050238 DNA Replication and Repair Clamp Loader Complex
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR013748 Replication factor C, C-terminal
      IPR047854 Replication factor C, lid domain
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 85

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13829, MGI:1924040, MGI:97894
    References
    more
    • Summaries
      All 48
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory