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Zbtb46
Gene Detail
 Symbol
Name
ID
Zbtb46
zinc finger and BTB domain containing 46
MGI:1919397
Synonyms 2610019F01Rik, 4933406L05Rik, Btbd4
Feature Type protein coding gene
Genetic Map
Chromosome 2
103.63 cM, cytoband H4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:181387762-181459426 bp, - strand
From VEGA annotation of GRCm38

  71665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zbtb46

Human
homologs
Human Homolog ZBTB46, zinc finger and BTB domain containing 46
NCBI Gene ID 140685
neXtProt AC  NX_Q86UZ6
Human Synonyms  BTBD4, BZEL, dJ583P15.7, dJ583P15.8, RINZF, ZNF340
Human Chr (Location)  20q13.33; chr20:63743668-63832377 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit repressed altered myeloid potential in dendritic cells. Mice homozygous for a different knock-out allele exhibit partial activation of classical dendritic cells in the steady state.
 
Interactions
Zbtb46 interacts with 333 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process negative regulation of dendritic cell differentiation, negative regulation of granulocyte differentiation, ...
Component nucleus
Function metal ion binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (32)    Tissues (23)    Images (2)
Theiler Stages: 2, 3, 4, 5, 23, 28
Assay TypeResults
RNA in situ 24
RT-PCR 8
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016707 (Evidence)
Ensembl Gene ModelENSMUSG00000027583 (Evidence)
Entrez Gene72147 (Evidence)
UniGene486504
DFCITC1583871, TC1589137, TC1610155, TC1621024, TC1768050
DoTSDT.482678, DT.55236894, DT.94176454, DT.94223884
NIA Mouse Gene IndexU023787
Consensus CDS ProjectCCDS17212.1, CCDS50854.1
International Mouse Knockout Project StatusZbtb46
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016707 VEGA Gene Model | MGI Sequence Detail 71665 C57BL/6J ±  kb
transcript OTTMUST00000040480 VEGA | MGI Sequence Detail 5309 Not Applicable 
polypeptide OTTMUSP00000018094 VEGA | MGI Sequence Detail 600 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(13) UniProt(3)
Polymorphisms SNPs within 2kb(510 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017587 zinc finger and BTB domain-containing protein 46
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:209372 Epelman S, et al., Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation. Immunity. 2014 Jan 16;40(1):91-104
All references(45)
Other
accession IDs
MGI:1918297

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory