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Zbtb46 Gene Detail
Summary
  • Symbol
    Zbtb46
  • Name
    zinc finger and BTB domain containing 46
  • Synonyms
    2610019F01Rik, 4933406L05Rik, Btbd4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919397
    NCBI Gene: 72147
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:181387762-181459426 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.63 cM, cytoband H4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    690 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919397
protein coding gene Chr2:181371261-181492983 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027024
protein coding gene Chr2:187976757-188055674 (-)
A/J MGP_AJ_G0026990
protein coding gene Chr2:180239846-180311254 (-)
AKR/J MGP_AKRJ_G0026960
protein coding gene Chr2:185642413-185720586 (-)
BALB/cJ MGP_BALBcJ_G0026998
protein coding gene Chr2:180712680-180790737 (-)
C3H/HeJ MGP_C3HHeJ_G0026740
protein coding gene Chr2:185994827-186071106 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027444
protein coding gene Chr2:193405824-193500279 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024808
protein coding gene Chr2:170921799-170996449 (-)
CAST/EiJ MGP_CASTEiJ_G0026199
protein coding gene Chr2:184260083-184335940 (-)
CBA/J MGP_CBAJ_G0026717
protein coding gene Chr2:200414919-200493357 (-)
DBA/2J MGP_DBA2J_G0026854
protein coding gene Chr2:179337838-179412724 (-)
FVB/NJ MGP_FVBNJ_G0026820
protein coding gene Chr2:177956665-178027763 (-)
LP/J MGP_LPJ_G0026956
protein coding gene Chr2:188000906-188077207 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026840
protein coding gene Chr2:202974805-203053891 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027504
protein coding gene Chr2:185610073-185686744 (-)
PWK/PhJ MGP_PWKPhJ_G0025935
protein coding gene Chr2:176861768-176934138 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025735
protein coding gene Chr2:182113629-182189741 (-)
WSB/EiJ MGP_WSBEiJ_G0026271
protein coding gene Chr2:186597194-186676589 (-)



Homology
more
  • Human Ortholog
    ZBTB46, zinc finger and BTB domain containing 46
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZBTB46, zinc finger and BTB domain containing 46
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTBD4, BZEL, dJ583P15.7, dJ583P15.8, RINZF, ZNF340
  • Links
    NCBI Gene ID: 140685
    neXtProt AC: NX_Q86UZ6
    UniProt: Q86UZ6

  • Chr Location
    20q13.33; chr20:63743668-63832332 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 5 alleles in 4 genetic backgrounds
    1 images
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit repressed altered myeloid potential in dendritic cells. Mice homozygous for a different knock-out allele exhibit partial activation of classical dendritic cells in the steady state.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027583 Ensembl Gene Model | MGI Sequence Detail 71665 C57BL/6J ±  kb
    transcript ENSMUST00000029106 Ensembl | MGI Sequence Detail 5309 Not Applicable  
    polypeptide ENSMUSP00000029106 Ensembl | MGI Sequence Detail 600 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 34
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1918297
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 44
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:270907 Giles DA, et al., CNS-resident classical DCs play a critical role in CNS autoimmune disease. J Clin Invest. 2018 Dec 3;128(12):5322-5334

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory