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Zbtb46
Gene Detail
Symbol

Name
ID
Zbtb46
zinc finger and BTB domain containing 46
MGI:1919397
Synonyms
2610019F01Rik, 4933406L05Rik, Btbd4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
103.63 cM, cytoband H4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:181387762-181459426 bp, - strand
From VEGA annotation of GRCm38

  71665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81908  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: ZBTB46
Gene Tree: Zbtb46

Human
homologs
ZBTB46, zinc finger and BTB domain containing 46
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 140685
neXtProt AC: NX_Q86UZ6

Human Synonyms: BTBD4, BZEL, dJ583P15.7, dJ583P15.8, RINZF, ZNF340

Human Chr (Location): 20q13.33; chr20:63743668-63832344 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit repressed altered myeloid potential in dendritic cells. Mice homozygous for a different knock-out allele exhibit partial activation of classical dendritic cells in the steady state.
 
Interactions
Zbtb46 interacts with 333 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process negative regulation of dendritic cell differentiation, negative regulation of granulocyte differentiation, ...
Component nucleus
Function metal ion binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (32)    Tissues (23)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 8
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase zbtb46    NEW 
Molecular
reagents
All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016707 (Evidence)
Ensembl Gene Model ENSMUSG00000027583 (Evidence)
Entrez Gene 72147 (Evidence)
UniGene 486504
DFCI TC1610155, TC1589137, TC1583871, TC1768050, TC1621024
DoTS DT.94223884, DT.94176454, DT.55236894, DT.482678
NIA Mouse Gene Index U023787
Consensus CDS Project CCDS17212.1, CCDS50854.1
International Mouse Phenotyping Consortium Status Zbtb46
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016707 VEGA Gene Model | MGI Sequence Detail 71665 C57BL/6J ±  kb
transcript OTTMUST00000040480 VEGA | MGI Sequence Detail 5309 Not Applicable 
polypeptide OTTMUSP00000018094 VEGA | MGI Sequence Detail 600 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(510 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017587 zinc finger and BTB domain-containing protein 46
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:217466 Broz ML, et al., Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014 Nov 10;26(5):638-52
All references(46)
Other
accession IDs
MGI:1918297

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory