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Zbtb46 Gene Detail
Summary
  • Symbol
    Zbtb46
  • Name
    zinc finger and BTB domain containing 46
  • Synonyms
    2610019F01Rik, 4933406L05Rik, Btbd4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919397
    NCBI Gene: 72147
Location & Maps
more
  • Sequence Map
    Chr2:181387762-181459426 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 103.63 cM, cytoband H4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ZBTB46, zinc finger and BTB domain containing 46
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZBTB46, zinc finger and BTB domain containing 46
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BTBD4, BZEL, dJ583P15.7, dJ583P15.8, RINZF, ZNF340
  • Links
    NCBI Gene ID: 140685
    neXtProt AC: NX_Q86UZ6

  • Chr Location
    20q13.33; chr20:63743668-63832344 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 5 alleles in 4 genetic backgrounds
    1 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit repressed altered myeloid potential in dendritic cells. Mice homozygous for a different knock-out allele exhibit partial activation of classical dendritic cells in the steady state.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016707 VEGA Gene Model | MGI Sequence Detail 71665 C57BL/6J ±  kb
transcript OTTMUST00000040480 VEGA | MGI Sequence Detail 5309 Not Applicable  
polypeptide OTTMUSP00000018094 VEGA | MGI Sequence Detail 600 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    690 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017587 zinc finger and BTB domain-containing protein 46
  • InterPro Domains
    IPR000210 BTB/POZ domain
    IPR011333 SKP1/BTB/POZ domain
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 33
    cDNA 32
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1918297
References
more
  • Summaries
    All 49
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 21
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:230709 Loschko J, et al., Inducible targeting of cDCs and their subsets in vivo. J Immunol Methods. 2016 Apr 9;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory