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Pygo1 Gene Detail
Summary
  • Symbol
    Pygo1
  • Name
    pygopus 1
  • Synonyms
    2600014C22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919385
    NCBI Gene: 72135
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:72832927-72859463 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 40.08 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    759 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919385
 protein coding gene Chr9:72832927-72859868 (+)
129S1/SvImJ ENSMUSG00200041905
 protein coding gene Chr9:69896267-69922823 (+)
A/J ENSMUSG00195024283
 protein coding gene Chr9:69681847-69708373 (+)
AKR/J ENSMUSG00220039358
 protein coding gene Chr9:69846307-69872842 (+)
BALB/cJ ENSMUSG00180017245
 protein coding gene Chr9:69796237-69822765 (+)
C3H/HeJ ENSMUSG00175011334
 protein coding gene Chr9:69809355-69835883 (+)
C57BL/6NJ ENSMUSG00215014994
 protein coding gene Chr9:69780033-69806577 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032422
 protein coding gene Chr9:70045012-70072298 (+)
CAST/EiJ ENSTCUG00005028167
 protein coding gene Chr9:69618788-69646151 (+)
CBA/J ENSMUSG00210013627
 protein coding gene Chr9:69889869-69916403 (+)
DBA/2J ENSMUSG00185031640
 protein coding gene Chr9:69913762-69940298 (+)
FVB/NJ ENSMUSG00205031624
 protein coding gene Chr9:70187195-70213727 (+)
JF1/MsJ ENSUMUG00000036165
 protein coding gene Chr9:69980151-70006804 (+)
LP/J ENSMUSG00230026390
 protein coding gene Chr9:70091230-70117782 (+)
NOD/ShiLtJ ENSMUSG00190021003
 protein coding gene Chr9:70017789-70044322 (+)
NZO/HlLtJ ENSMUSG00225045219
 protein coding gene Chr9:70220319-70246851 (+)
PWK/PhJ ENSLUMG00010023951
 protein coding gene Chr9:69894360-69921017 (+)
SPRET/EiJ ENSMSPG00010003704
 protein coding gene Chr9:70983081-71005930 (+)
WSB/EiJ ENSIUOG00005025885
 protein coding gene Chr9:69399206-69425783 (+)



Homology
more
  • Human Ortholog
    PYGO1, pygopus family PHD finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PYGO1, pygopus family PHD finger 1
  • Links
    NCBI Gene ID: 26108
    UniProt: Q9Y3Y4

  • Chr Location
    15q21.3; chr15:55538884-55588971 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    1 images
    15 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Pygo1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    22 strains or lines available
Homozygous null mice are viable and show no obvious phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    149
  • cDNA Data
    20
  • Literature Summary
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034910 Ensembl Gene Model | MGI Sequence Detail 26537 C57BL/6J ±  kb
transcript ENSMUST00000038489 Ensembl | MGI Sequence Detail 7916 Not Applicable  
polypeptide ENSMUSP00000044368 Ensembl | MGI Sequence Detail 417 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 20
    Primer pair 5
    Antibodies 1

    Microarray probesets 2
References
more
  • Summaries
    All 56
    Developmental Gene Expression 13
    Gene Ontology 11
    Phenotypes 15
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:370212 Hu L, et al., Mettl3 Regulates Lens Development by Promoting the Differentiation Processes of Secondary Fiber Cells. Invest Ophthalmol Vis Sci. 2025 Jul 1;66(9):45
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory