Naa50 MGI Mouse Gene Detail - MGI:1919367 - N(alpha)-acetyltransferase 50, NatE catalytic subunit

Symbol

Naa50
Name

N(alpha)-acetyltransferase 50, NatE catalytic subunit
Synonyms

2600005K24Rik, 2810441M03Rik, Mak3p, Nat13, Nat5, San

Feature Type

protein coding gene
IDs

MGI:1919367
NCBI Gene: 72117
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr16:43960193-43983729 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 28.47 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

51 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919367	protein coding gene	Chr16:43960154-43983825 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022835	protein coding gene	Chr16:42870392-42898720 (+)
A/J	MGP_AJ_G0022800	protein coding gene	Chr16:40940087-40963840 (+)
AKR/J	MGP_AKRJ_G0022772	protein coding gene	Chr16:42252204-42275854 (+)
BALB/cJ	MGP_BALBcJ_G0022801	protein coding gene	Chr16:40928426-40951404 (+)
C3H/HeJ	MGP_C3HHeJ_G0022565	protein coding gene	Chr16:42447358-42472983 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023248	protein coding gene	Chr16:43861025-43882921 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020763	protein coding gene	Chr16:40994412-41016359 (+)
CAST/EiJ	MGP_CASTEiJ_G0022091	protein coding gene	Chr16:42646434-42671204 (+)
CBA/J	MGP_CBAJ_G0022536	protein coding gene	Chr16:45707481-45735322 (+)
DBA/2J	MGP_DBA2J_G0022668	protein coding gene	Chr16:40684250-40707537 (+)
FVB/NJ	MGP_FVBNJ_G0022643	protein coding gene	Chr16:40643436-40665501 (+)
LP/J	MGP_LPJ_G0022736	protein coding gene	Chr16:42584354-42610968 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022662	protein coding gene	Chr16:45101854-45138317 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023263	protein coding gene	Chr16:42279164-42303111 (+)
PWK/PhJ	MGP_PWKPhJ_G0021831	protein coding gene	Chr16:41068486-41092562 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021662	protein coding gene	Chr16:42174815-42200894 (+)
WSB/EiJ	MGP_WSBEiJ_G0022135	protein coding gene	Chr16:42372838-42395985 (+)

Human Ortholog

NAA50, N-alpha-acetyltransferase 50, NatE catalytic subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NAA50, N-alpha-acetyltransferase 50, NatE catalytic subunit
Synonyms

hNaa50p, MAK3, NAT13, NAT13P, NAT5, NAT5P, SAN
Links

HGNC:29533

NCBI Gene ID: 80218

neXtProt AC: NX_Q9GZZ1

UniProt: Q9GZZ1
Chr Location

3q13.31; chr3:113716458-113746300 (-) GRCh38

MGI Vertebrate Homology

Naa50 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NAA50
Gene Tree

Naa50

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Endonuclease-mediated

3
Gene trapped

28
Targeted

4
Incidental Mutations

APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

97
cDNA Data

212
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase naa50

ZFIN naa50

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All Sequences

67
RefSeq

6
UniProt

1
CCDS

CCDS28183.1, CCDS84236.1

Ensembl

ENSMUSG00000022698 (Evidence)
NCBI Gene

72117

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022698	Ensembl Gene Model \| MGI Sequence Detail	23537	C57BL/6J	± kb
transcript	ENSMUST00000159514	Ensembl \| MGI Sequence Detail	3756	Not Applicable
polypeptide	ENSMUSP00000125517	Ensembl \| MGI Sequence Detail	175	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010998 N-alpha-acetyltransferase 50

(term hierarchy)
EC

2.3.1.-, 2.3.1.258
InterPro Domains

IPR016181 Acyl-CoA N-acyltransferase

IPR000182 GNAT domain

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All nucleic 213

cDNA 212

Primer pair 1

Microarray probesets 7

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MGI:1919982, MGI:2146622

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 12
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:149737 Sansom SN, et al., The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511

TSS for Naa50:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138537	Chr16:43959512-43959524 (+)	-675 bp
Tssr138538	Chr16:43960184-43960263 (+)	31 bp
Tssr138539	Chr16:43962982-43962993 (+)	2,795 bp
Tssr138540	Chr16:43966681-43966685 (+)	6,490 bp
Tssr138541	Chr16:43976784-43976806 (+)	16,602 bp
Tssr138542	Chr16:43980053-43980089 (+)	19,878 bp
Tssr138543	Chr16:43980112-43980128 (+)	19,927 bp
Tssr138544	Chr16:43980464-43980477 (+)	20,278 bp
Tssr138545	Chr16:43980669-43980688 (+)	20,486 bp
Tssr138546	Chr16:43980705-43980731 (+)	20,525 bp
Tssr138547	Chr16:43981715-43981762 (+)	21,546 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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