Jmjd8 Gene Detail

Summary

• Symbol
  Jmjd8
• Name
  jumonji domain containing 8
• Synonyms
  2610003J06Rik

• Feature Type
  protein coding gene
• IDs
  MGI:1919356
  NCBI Gene: 72106
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr17:26048017-26050817 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 17, 12.92 cM, cytoband B1
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  22 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919356	protein coding gene	Chr17:26047841-26050817 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023372	protein coding gene	Chr17:24926200-24929175 (+)
A/J	MGP_AJ_G0023331	protein coding gene	Chr17:24201772-24204745 (+)
AKR/J	MGP_AKRJ_G0023297	protein coding gene	Chr17:24307333-24310308 (+)
BALB/cJ	MGP_BALBcJ_G0023336	protein coding gene	Chr17:24429843-24432818 (+)
C3H/HeJ	MGP_C3HHeJ_G0023096	protein coding gene	Chr17:24690942-24693917 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023778	protein coding gene	Chr17:25979257-25982232 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021254	protein coding gene	Chr17:21663331-21666291 (+)
CAST/EiJ	MGP_CASTEiJ_G0022598	protein coding gene	Chr17:24576304-24579259 (+)
CBA/J	MGP_CBAJ_G0023071	protein coding gene	Chr17:26890937-26893912 (+)
DBA/2J	MGP_DBA2J_G0023201	protein coding gene	Chr17:23804446-23807421 (+)
FVB/NJ	MGP_FVBNJ_G0023171	protein coding gene	Chr17:23544596-23547571 (+)
LP/J	MGP_LPJ_G0023278	protein coding gene	Chr17:25226857-25229832 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023190	protein coding gene	Chr17:26503292-26506267 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023818	protein coding gene	Chr17:24626858-24629833 (+)
PWK/PhJ	MGP_PWKPhJ_G0022347	protein coding gene	Chr17:22565764-22568731 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022165	protein coding gene	Chr17:22700651-22703623 (+)
WSB/EiJ	MGP_WSBEiJ_G0022661	protein coding gene	Chr17:24677570-24680534 (+)

Homology

• Human Ortholog
  JMJD8, jumonji domain containing 8

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  JMJD8, jumonji domain containing 8
  
• Synonyms
  C16orf20, PP14397
• Links
  HGNC:14148

  NCBI Gene ID: 339123

  neXtProt AC: NX_Q96S16

  UniProt: Q96S16

  
  
• Chr Location
  16p13.3; chr16:681670-684528 (-)  GRCh38

---

• MGI Vertebrate Homology
  Jmjd8 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: JMJD8
• Gene Tree
  Jmjd8
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  15 phenotypes from 4 alleles in 4 genetic backgrounds
  10 phenotype references
  

• All Mutations and Alleles
  9
• Endonuclease-mediated
  1
• Radiation induced
  2
• Targeted
  5
• Transgenic
  1
• Genomic Mutations
  2 involving Jmjd8
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  19 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced capillaries in muscle tissue and reduced glycolysis in isolated cells. Mice for another null allele exhibit increased insulin sensitivity and glucose tolerance.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  17
• GO References
  3

Expression

• Assay Results
  713
• Tissues
  7
• cDNA Data
  7
• Literature Summary
  2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase jmjd8

Sequences &
Gene Models

• All Sequences
  45
• RefSeq
  2
• UniProt
  3
• CCDS
  CCDS28532.2

• Ensembl
  ENSMUSG00000025736 (Evidence)
• NCBI Gene
  72106

Representative Sequences			Length	Strain/Species
genomic	72106	NCBI Gene Model | MGI Sequence Detail	2801	C57BL/6J
transcript	NM_028101	RefSeq | MGI Sequence Detail	2107	C57BL/6
polypeptide	Q3TA59	UniProt | EBI | MGI Sequence Detail	269	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000030550 JmjC domain-containing protein 8
  (term hierarchy)
• InterPro Domains
  IPR041667 Cupin-like domain 8
  IPR003347 JmjC domain

Molecular
Reagents

• All nucleic 7

  cDNA 7

  
  

  Microarray probesets 5

References

• Summaries
  All 33

  Developmental Gene Expression 2

  Gene Ontology 3

  Phenotypes 10
• Earliest
  J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
• Latest
  J:319518 You D, et al., JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance. Diabetes. 2021 Oct 21;

TSS for Jmjd8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5041	Chr17:26046836-26046884 (+)	-1,157 bp
Tssr143191	Chr17:26047765-26047800 (+)	-234 bp
Tssr143192	Chr17:26048010-26048050 (+)	13 bp