Megf6 MGI Mouse Gene Detail - MGI:1919351 - multiple EGF-like-domains 6

Symbol

Megf6
Name

multiple EGF-like-domains 6
Synonyms

2600001P17Rik, Egfl3, MGC:49785

Feature Type

protein coding gene
IDs

MGI:1919351
NCBI Gene: 230971
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:154170730-154275713 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 83.89 cM
Mapping Data

2 experiments

SNPs within 2kb

1109 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919351	protein coding gene	Chr4:154170713-154275721 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029194	protein coding gene	Chr4:158424184-158537276 (+)
A/J	MGP_AJ_G0029159	protein coding gene	Chr4:151774628-151880349 (+)
AKR/J	MGP_AKRJ_G0029107	protein coding gene	Chr4:155918385-156028836 (+)
BALB/cJ	MGP_BALBcJ_G0029175	protein coding gene	Chr4:152243902-152350953 (+)
C3H/HeJ	MGP_C3HHeJ_G0028896	protein coding gene	Chr4:156454844-156564369 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029624	protein coding gene	Chr4:164089747-164204835 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026870	protein coding gene	Chr4:144077483-144184361 (+)
CAST/EiJ	MGP_CASTEiJ_G0028309	protein coding gene	Chr4:153856209-153967329 (+)
CBA/J	MGP_CBAJ_G0028858	protein coding gene	Chr4:169015337-169140137 (+)
DBA/2J	MGP_DBA2J_G0029007	protein coding gene	Chr4:151801480-151909313 (+)
FVB/NJ	MGP_FVBNJ_G0028971	protein coding gene	Chr4:151004058-151113831 (+)
LP/J	MGP_LPJ_G0029097	protein coding gene	Chr4:158333421-158444759 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028998	protein coding gene	Chr4:171931879-172046554 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029656	protein coding gene	Chr4:156480349-156591663 (+)
PWK/PhJ	MGP_PWKPhJ_G0028029	protein coding gene	Chr4:147885268-147998865 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027863	protein coding gene	Chr4:150779533-150892328 (+)
WSB/EiJ	MGP_WSBEiJ_G0028389	protein coding gene	Chr4:156651105-156762452 (+)

Human Ortholog

MEGF6, multiple EGF like domains 6

Vertebrate Orthologs

11

Human Ortholog

MEGF6, multiple EGF like domains 6
Orthology source: HomoloGene, HGNC
Synonyms

EGFL3
Links

HGNC:3232

NCBI Gene ID: 1953

neXtProt AC: NX_O75095

UniProt: O75095
Chr Location

1p36.32; chr1:3487942-3624757 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 45412
1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: MEGF6
Gene Tree

Megf6

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

4
Targeted

4
Genomic Mutations

3 involving Megf6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available

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All GO Annotations

3
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

143
Tissues

17
cDNA Data

60
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Megf6 interacts with 246 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

68
RefSeq

8
UniProt

6
CCDS

CCDS51398.1
UniGene

275216

Ensembl

ENSMUSG00000057751 (Evidence)
NCBI Gene

230971

			Length	Strain/Species	Flank
genomic	ENSMUSG00000057751	Ensembl Gene Model \| MGI Sequence Detail	104984	C57BL/6J	± kb
transcript	ENSMUST00000030897	Ensembl \| MGI Sequence Detail	6851	Not Applicable
polypeptide	ENSMUSP00000030897	Ensembl \| MGI Sequence Detail	1572	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000032481 multiple epidermal growth factor-like domains protein 6

(term hierarchy)
InterPro Domains

IPR026823 Complement Clr-like EGF domain

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR013111 EGF-like domain, extracellular

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR011489 EMI domain

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR002049 Laminin EGF domain

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All nucleic 60

cDNA 60

Microarray probesets 13

Summaries

All 31

Developmental Gene Expression 2

Gene Ontology 3

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:271659 Wang Y, et al., Generation and characterization of Megf6 null and Cre knock-in alleles. Genesis. 2019 Feb;57(2):e23262

TSS for Megf6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40578	Chr4:154170731-154170742 (+)	7 bp
Tssr40579	Chr4:154170744-154170769 (+)	27 bp
Tssr40580	Chr4:154170770-154170806 (+)	58 bp
Tssr40583	Chr4:154237549-154237571 (+)	66,830 bp
Tssr40584	Chr4:154237577-154237608 (+)	66,863 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/14/2019 MGI 6.14