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Megf6 Gene Detail
Summary
  • Symbol
    Megf6
  • Name
    multiple EGF-like-domains 6
  • Synonyms
    2600001P17Rik, Egfl3, MGC:49785
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919351
    NCBI Gene: 230971
Location & Maps
more
  • Sequence Map
    Chr4:154170730-154275713 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      104984 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 83.89 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MEGF6, multiple EGF like domains 6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MEGF6, multiple EGF like domains 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EGFL3
  • Links
    NCBI Gene ID: 1953
    neXtProt AC: NX_O75095

  • Chr Location
    1p36.3; chr1:3487942-3624757 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Genomic Mutations
    3 involving Megf6
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    143
  • Tissues
    17
  • cDNA Data
    59
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010501 VEGA Gene Model | MGI Sequence Detail 104984 C57BL/6J ±  kb
transcript OTTMUST00000024496 VEGA | MGI Sequence Detail 6851 Not Applicable  
polypeptide OTTMUSP00000011264 VEGA | MGI Sequence Detail 1572 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1109 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000032481 multiple epidermal growth factor-like domains protein 6
  • InterPro Domains
    IPR026823 Complement Clr-like EGF domain
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR013111 EGF-like domain, extracellular
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR011489 EMI domain
    IPR009030 Growth factor receptor cysteine-rich domain
    IPR002049 Laminin EGF domain
Molecular
Reagents
less
  • All nucleic 59
    cDNA 59

    Microarray probesets 13
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory