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Slc39a5 Gene Detail
Summary
  • Symbol
    Slc39a5
  • Name
    solute carrier family 39 (metal ion transporter), member 5
  • Synonyms
    1810013D05Rik, 2010205A06Rik, Zip5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919336
    NCBI Gene: 72002
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128395931-128401229 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.55 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1919336
 protein coding gene Chr10:128395927-128401276 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017863
 protein coding gene Chr10:132129644-132134936 (-)
A/J MGP_AJ_G0017838
 protein coding gene Chr10:126822318-126827610 (-)
AKR/J MGP_AKRJ_G0017801
 protein coding gene Chr10:130545780-130551069 (-)
BALB/cJ MGP_BALBcJ_G0017802
 protein coding gene Chr10:127205309-127210604 (-)
C3H/HeJ MGP_C3HHeJ_G0017625
 protein coding gene Chr10:130709190-130714506 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018257
 protein coding gene Chr10:136607088-136612378 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015935
 protein coding gene Chr10:120756853-120762157 (-)
CAST/EiJ MGP_CASTEiJ_G0017186
 protein coding gene Chr10:131419100-131424397 (-)
CBA/J MGP_CBAJ_G0017595
 protein coding gene Chr10:142153756-142159045 (-)
DBA/2J MGP_DBA2J_G0017701
 protein coding gene Chr10:125883648-125888938 (-)
FVB/NJ MGP_FVBNJ_G0017696
 protein coding gene Chr10:124813015-124818317 (-)
LP/J MGP_LPJ_G0017775
 protein coding gene Chr10:132722242-132727531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017724
 protein coding gene Chr10:144759292-144764582 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018297
 protein coding gene Chr10:130645803-130651098 (-)
PWK/PhJ MGP_PWKPhJ_G0016971
 protein coding gene Chr10:126143834-126149123 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016760
 protein coding gene Chr10:129740251-129745446 (-)
WSB/EiJ MGP_WSBEiJ_G0017245
 protein coding gene Chr10:130861634-130866923 (-)



Homology
more
  • Human Ortholog
    SLC39A5, solute carrier family 39 member 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC39A5, solute carrier family 39 member 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LZT-Hs7, MYP24, ZIP5
  • Links
    NCBI Gene ID: 283375
    neXtProt AC: NX_Q6ZMH5
    UniProt: Q6ZMH5

  • Chr Location
    12q13.3; chr12:56230036-56237846 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human SLC39A5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered zinc homeostasis and increased susceptibility to zinc-induced pancretitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    56
  • Tissues
    40
  • cDNA Data
    25
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039878 Ensembl Gene Model | MGI Sequence Detail 5299 C57BL/6J ±  kb
    transcript ENSMUST00000042666 Ensembl | MGI Sequence Detail 1947 Not Applicable  
    polypeptide ENSMUSP00000037753 Ensembl | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 26
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919252
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
    • Latest
      J:254216 Bin BH, et al., Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis. Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12243-12248
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    03/13/2019
    MGI 6.13     		The Jackson Laboratory