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Slc39a5 Gene Detail
Summary
  • Symbol
    Slc39a5
  • Name
    solute carrier family 39 (metal ion transporter), member 5
  • Synonyms
    1810013D05Rik, 2010205A06Rik, Zip5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919336
    NCBI Gene: 72002
Location & Maps
more
  • Sequence Map
    Chr10:128395934-128401224 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5291 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 76.55 cM, cytoband D3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC39A5, solute carrier family 39 member 5
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC39A5, solute carrier family 39 member 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LZT-Hs7, MYP24, ZIP5
  • Links
    NCBI Gene ID: 283375
    neXtProt AC: NX_Q6ZMH5

  • Chr Location
    12q13.3; chr12:56230036-56237846 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC39A5 associations

Human Disease Mouse Models
       Myopia 24, Autosomal Dominant; MYP24   OMIM: 615946
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 4 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered zinc homeostasis and increased susceptibility to zinc-induced pancretitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039878 Ensembl Gene Model | MGI Sequence Detail 5291 C57BL/6J ±  kb
transcript ENSMUST00000167859 Ensembl | MGI Sequence Detail 2025 Not Applicable  
polypeptide ENSMUSP00000131736 Ensembl | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    45 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015132 zinc transporter ZIP5
  • InterPro Domains
    IPR003689 Zinc/iron permease
Molecular
Reagents
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  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1919252
References
more
  • Summaries
    All 40
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory