Slc39a5 MGI Mouse Gene Detail - MGI:1919336 - solute carrier family 39 (metal ion transporter), member 5

Slc39a5 Gene Detail

Symbol

Slc39a5
Name

solute carrier family 39 (metal ion transporter), member 5
Synonyms

1810013D05Rik, 2010205A06Rik, Zip5

Feature Type

protein coding gene
IDs

MGI:1919336
NCBI Gene: 72002

Sequence Map

Chr10:128395931-128401229 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

5299 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.55 cM, cytoband D3
Mapping Data

2 experiments

Human Ortholog

SLC39A5, solute carrier family 39 member 5

Vertebrate Orthologs

7

Human Ortholog

SLC39A5, solute carrier family 39 member 5
Orthology source: HomoloGene, HGNC
Synonyms

LZT-Hs7, MYP24, ZIP5
Links

HGNC:20502

NCBI Gene ID: 283375

neXtProt AC: NX_Q6ZMH5

UniProt: Q6ZMH5
Chr Location

12q13.3; chr12:56230036-56237846 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 57083
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 macaque, rhesus
HCOP

human homology predictions: SLC39A5
Gene Tree

Slc39a5

Diseases

1 with human SLC39A5 associations

				Human Disease	Mouse Models
				myopia IDs myopia DOID:11830 EFO:0003927 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613959 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 3 alleles in 4 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

Mice homozygous for a knock-out allele exhibit altered zinc homeostasis and increased susceptibility to zinc-induced pancretitis.

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All GO Annotations

21
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

38
Tissues

32
cDNA Data

24
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Slc39a5 interacts with 56 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

35
RefSeq

13
UniProt

3
CCDS

CCDS24275.1
UniGene

22983

Ensembl

ENSMUSG00000039878 (Evidence)
NCBI Gene

72002

			Length	Strain/Species	Flank
genomic	ENSMUSG00000039878	Ensembl Gene Model \| MGI Sequence Detail	5299	C57BL/6J	± kb
transcript	ENSMUST00000042666	Ensembl \| MGI Sequence Detail	1947	Not Applicable
polypeptide	ENSMUSP00000037753	Ensembl \| MGI Sequence Detail	535	Not Applicable

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SNPs within 2kb

45 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000015132 zinc transporter ZIP5

(term hierarchy)
InterPro Domains

IPR003689 Zinc/iron permease

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All nucleic 26

cDNA 25

Primer pair 1

Microarray probesets 3

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MGI:1919252

Summaries

All 41

Developmental Gene Expression 7

Gene Ontology 6

Phenotypes 9
Earliest

J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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