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Cnot2 Gene Detail
Summary
  • Symbol
    Cnot2
  • Name
    CCR4-NOT transcription complex, subunit 2
  • Synonyms
    2600016M12Rik, 2810470K03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1919318
    NCBI Gene: 72068
  • Gene Overview
    MyGene.info: CNOT2
Location & Maps
more
  • Sequence Map
    Chr10:116485165-116581511 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      96347 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 64.76 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CNOT2, CCR4-NOT transcription complex subunit 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CNOT2, CCR4-NOT transcription complex subunit 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDC36, HSPC131, NOT2, NOT2H
  • Links
    NCBI Gene ID: 4848
    neXtProt AC: NX_Q9NZN8

  • Chr Location
    12q15; chr12:70242994-70354993 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    636
  • Chemically induced (other)
    1
  • Gene trapped
    631
  • Targeted
    4
  • Genomic Mutations
    1 involving Cnot2
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    78
  • Tissues
    70
  • cDNA Data
    23
  • Literature Summary
    6
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035217 VEGA Gene Model | MGI Sequence Detail 96347 C57BL/6J ±  kb
transcript OTTMUST00000089726 VEGA | MGI Sequence Detail 2800 Not Applicable  
polypeptide OTTMUSP00000049065 VEGA | MGI Sequence Detail 540 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    789 from dbSNP Build 142
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000005650 CCR4-NOT transcription complex subunit 2
  • InterPro Domains
    IPR007282 NOT2/NOT3/NOT5
Molecular
Reagents
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  • All nucleic 25
    Genomic 1
    cDNA 23
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1925587, MGI:2143488, MGI:2143511, MGI:2143869, MGI:2143929
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:196241 Zheng X, et al., Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation. Stem Cells. 2012 May;30(5):910-22
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory