Aopep MGI Mouse Gene Detail - MGI:1919311

Symbol

Aopep
Name

aminopeptidase O
Synonyms

2010111I01Rik, 2300006M17Rik, ApO

Feature Type

protein coding gene
IDs

MGI:1919311
NCBI Gene: 72061
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr13:62964893-63326096 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 32.80 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

1841 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1919311	protein coding gene	Chr13:62964893-63326096 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020668	protein coding gene	Chr13:62962524-63286204 (+)
A/J	MGP_AJ_G0020622	protein coding gene	Chr13:60688853-60984362 (+)
AKR/J	MGP_AKRJ_G0020599	protein coding gene	Chr13:62710928-63026673 (+)
BALB/cJ	MGP_BALBcJ_G0020620	protein coding gene	Chr13:61108120-61412987 (+)
C3H/HeJ	MGP_C3HHeJ_G0020415	protein coding gene	Chr13:62243537-62559097 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021056	protein coding gene	Chr13:65011365-65348338 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018632	protein coding gene	Chr13:58366159-58658283 (+)
CAST/EiJ	MGP_CASTEiJ_G0019932	protein coding gene	Chr13:62251297-62561655 (+)
CBA/J	MGP_CBAJ_G0020375	protein coding gene	Chr13:67520816-67867841 (+)
DBA/2J	MGP_DBA2J_G0020500	protein coding gene	Chr13:60527721-60827280 (+)
FVB/NJ	MGP_FVBNJ_G0020479	protein coding gene	Chr13:59644084-59944776 (+)
LP/J	MGP_LPJ_G0020574	protein coding gene	Chr13:63248030-63563000 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020508	protein coding gene	Chr13:66527269-66841064 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021098	protein coding gene	Chr13:62015133-62331119 (+)
PWK/PhJ	MGP_PWKPhJ_G0019686	protein coding gene	Chr13:60080489-60385618 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019512	protein coding gene	Chr13:60184978-60486744 (+)
WSB/EiJ	MGP_WSBEiJ_G0019992	protein coding gene	Chr13:62515612-62821346 (+)

Human Ortholog

AOPEP, aminopeptidase O (putative)

Vertebrate Orthologs

10

Human Ortholog

AOPEP, aminopeptidase O (putative)
Orthology source: HomoloGene, HGNC
Synonyms

APO, AP-O, C90RF3, C9orf3, ONPEP
Links

HGNC:1361

NCBI Gene ID: 84909

neXtProt AC: NX_Q8N6M6

UniProt: Q8N6M6
Chr Location

9q22.32; chr9:94726604-95148264 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 66273
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: AOPEP
Gene Tree

Aopep

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

82
Chemically induced (other)

1
Gene trapped

78
Targeted

3
Genomic Mutations

1 involving Aopep
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one gene trapped allele are phenotypically normal.

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All GO Annotations

13
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

664
Tissues

17
cDNA Data

25
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase aopep

ZFIN aopep

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Aopep interacts with 247 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

112
RefSeq

7
UniProt

16
CCDS

CCDS36699.1

Ensembl

ENSMUSG00000021458 (Evidence)
NCBI Gene

72061

			Length	Strain/Species	Flank
genomic	72061	NCBI Gene Model \| MGI Sequence Detail	361204	C57BL/6J	± kb
transcript	NM_001289926	RefSeq \| MGI Sequence Detail	6778	C57BL/6
polypeptide	Q8BXQ6	UniProt \| EBI \| MGI Sequence Detail	817	Not Applicable

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UniProt

16 Sequences
Protein Ontology

PR:000011642 aminopeptidase O

(term hierarchy)
EC

3.4.11.-
InterPro Domains

IPR034015 Aminopeptidase, leukotriene A4 hydrolase-like

IPR042097 Aminopeptidase N-like , N-terminal

IPR033577 Aminopeptidase O

IPR016024 Armadillo-type fold

IPR015211 Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal

IPR038502 Peptidase M1 LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily

IPR014782 Peptidase M1, membrane alanine aminopeptidase

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All nucleic 27

Genomic 1

cDNA 26

Microarray probesets 7

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MGI:1916716, MGI:2145468

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 14
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:249029 Shen L, et al., MicroRNA-27b Regulates Mitochondria Biogenesis in Myocytes. PLoS One. 2016;11(2):e0148532

TSS for Aopep:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120163	Chr13:62964867-62964931 (+)	6 bp
Tssr120164	Chr13:62964938-62964951 (+)	52 bp
Tssr120170	Chr13:63151508-63151530 (+)	186,626 bp
Tssr120171	Chr13:63151534-63151547 (+)	186,648 bp
Tssr120172	Chr13:63239551-63239576 (+)	274,671 bp
Tssr120173	Chr13:63240013-63240051 (+)	275,139 bp
Tssr120174	Chr13:63240056-63240093 (+)	275,182 bp
Tssr120175	Chr13:63240386-63240400 (+)	275,500 bp
Tssr120176	Chr13:63240545-63240567 (+)	275,663 bp
Tssr120184	Chr13:63272596-63272600 (+)	307,705 bp
Tssr120185	Chr13:63272793-63272808 (+)	307,908 bp
Tssr120186	Chr13:63272987-63273005 (+)	308,103 bp
Tssr120193	Chr13:63301270-63301276 (+)	336,380 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16