2010111I01Rik Gene Detail

Summary

• Symbol
  2010111I01Rik
• Name
  RIKEN cDNA 2010111I01 gene
• Synonyms
  2300006M17Rik, aminopeptidase O, ApO

• Feature Type
  protein coding gene
• IDs
  MGI:1919311
  NCBI Gene: 72061

Location & Maps

• Sequence Map
  Chr13:63282142-63326096 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    43955 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 32.80 cM, cytoband B3
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  C9orf3, chromosome 9 open reading frame 3

• Vertebrate Orthologs
  10

• Human Ortholog
  C9orf3, chromosome 9 open reading frame 3
  Orthology source: HomoloGene, HGNC
• Synonyms
  AOPEP, APO, AP-O, C90RF3, ONPEP
• Links
  HGNC:1361

  NCBI Gene ID: 84909

  neXtProt AC: NX_Q8N6M6

  UniProt: Q8N6M6

  
  
• Chr Location
  9q22.32; chr9:94726604-95148264 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 66273
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: C9orf3
• Gene Tree
  2010111I01Rik
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  11 phenotype references
  

• All Mutations and Alleles
  81
• Chemically induced (other)
  1
• Gene trapped
  78
• Targeted
  2
• Genomic Mutations
  1 involving 2010111I01Rik
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  37 strains or lines available

Mice homozygous for one gene trapped allele are phenotypically normal.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  16
• GO References
  6

• External Resources
  FuncBase

Expression

• Assay Results
  33
• Tissues
  17
• cDNA Data
  24
• Literature Summary
  1

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN zgc:162939

Interactions

• 2010111I01Rik interacts with 247 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

Sequences &
Gene Models

• All Sequences
  56
• RefSeq
  7
• UniProt
  8
• CCDS
  CCDS36699.1

• VEGA
  OTTMUSG00000030849 (Evidence)
• Ensembl
  ENSMUSG00000021458 (Evidence)
• NCBI Gene
  72061

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000030849	VEGA Gene Model | MGI Sequence Detail	43955	C57BL/6J
transcript	OTTMUST00000076332	VEGA | MGI Sequence Detail	2667	Not Applicable
polypeptide	OTTMUSP00000040169	VEGA | MGI Sequence Detail	114	Not Applicable

Polymorphisms

• SNPs within 2kb
  1841 from dbSNP Build 142

Protein
Information

• UniProt
  8 Sequences
• EC
  3.4.11.-
• InterPro Domains
  IPR033577 Aminopeptidase O
  IPR016024 Armadillo-type fold
  IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
  IPR015211 Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal
  IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal

Molecular
Reagents

• All nucleic 25

  cDNA 25

  
  

  Microarray probesets 7

Other
Accession IDs

MGI:1916716, MGI:2145468

References

• Summaries
  All 36

  Developmental Gene Expression 1

  Gene Ontology 6

  Phenotypes 11
• Earliest
  J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42