Tnfrsf13c
Gene Detail

Symbol Name ID

Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c MGI:1919299

Synonyms

2010006P15Rik, Baffr, BAFF-R, Bcmd1, Bcmd-1, Lvis22

Feature Type

protein coding gene

Genetic Map

Chromosome 15

38.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr15:82221744-82224336 bp, - strand From NCBI annotation of GRCm38   2593 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49897  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: tumor necrosis factor receptor superfamily member 13C
Gene Tree: Tnfrsf13c

Human homologs

Human Homolog		TNFRSF13C, tumor necrosis factor receptor superfamily, member 13C
NCBI Gene ID		115650
neXtProt AC		NX_Q96RJ3
Human Synonyms		BAFFR, BAFF-R, BROMIX, CD268, CVID4, prolixin
Human Chr (Location)		22q13.1-q13.31; chr22:42321036-42322821 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TNFRSF13C

Alleles and phenotypes

All alleles(6) : Targeted(4) QTL(2)
 

Homozygous inactivation of this gene results in defective splenic B-cell maturation, reduced marginal zone B-cell numbers, and impaired T-cell-dependent antibody formation.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	B cell costimulation, B cell homeostasis, ...
Component	external side of plasma membrane, integral to membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (36)    Tissues (27)    Images (2)
Theiler Stages: 16, 17, 18, 23, 28

Assay Type	Results
RNA in situ	24
Northern blot	12

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000068105 (Evidence)
Entrez Gene	72049 (Evidence)
UniGene	240047
DFCI	TC1584455, TC1596344
DoTS	DT.101168738, DT.110818444, DT.87066474
NIA Mouse Gene Index	U036447
Consensus CDS Project	CCDS27684.1
International Mouse Knockout Project Status	Tnfrsf13c

Sequences

Length	Strain/Species
genomic	72049	NCBI Gene Model | MGI Sequence Detail	2593	C57BL/6J
transcript	NM_028075	RefSeq | MGI Sequence Detail	1906	C57BL/6
polypeptide	Q9D8D0	UniProt | EBI | MGI Sequence Detail	175	Not Applicable

All sequences(29) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022338	Tumour necrosis factor receptor 13C
InterPro	IPR015336	Tumour necrosis factor receptor 13C, TALL-1 binding domain
Protein Ontology	PR:000001957	tumor necrosis factor receptor superfamily member 13C

Graphical View of Protein Domain Structure

References

(Earliest) J:25731 Miller DJ, et al., Phenotypic and genetic characterization of a unique B lymphocyte deficiency in strain A/WySnJ mice. Eur J Immunol. 1991 May;21(5):1123-30
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(59)

Other accession IDs

MGD-MRK-23965, MGI:103101