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Tnfrsf13c
Gene Detail
Symbol

Name
ID
Tnfrsf13c
tumor necrosis factor receptor superfamily, member 13c
MGI:1919299
Synonyms
2010006P15Rik, Baffr, BAFF-R, Bcmd1, Bcmd-1, Lvis22
Feature Type
protein coding gene
Genetic Map
Chromosome 15
38.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:82221744-82224336 bp, - strand
From NCBI annotation of GRCm38

  2593 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49897  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Protein SuperFamily: tumor necrosis factor receptor superfamily member 13C
Gene Tree: Tnfrsf13c

Human
homologs
Human Homolog TNFRSF13C, tumor necrosis factor receptor superfamily, member 13C
NCBI Gene ID 115650
neXtProt AC  NX_Q96RJ3
Human Synonyms  BAFFR, BAFF-R, BROMIX, CD268, CVID4, prolixin
Human Chr (Location)  22q13.1-q13.31; chr22:41925032-41926817 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TNFRSF13C
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : QTL(2) Radiation induced(1) Targeted(5)
Genomic Mutations involving Tnfrsf13c (1)
 
Homozygous inactivation of this gene results in defective splenic B-cell maturation, reduced marginal zone B-cell numbers, and impaired T-cell-dependent antibody formation.
 
Interactions
Tnfrsf13c interacts with 141 markers (Mir10b, Mir22, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process B cell costimulation, B cell homeostasis, ...
Component external side of plasma membrane, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (36)    Tissues (27)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 12
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(18) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000068105 (Evidence)
Entrez Gene72049 (Evidence)
UniGene240047
DFCITC1584455, TC1596344
DoTSDT.101168738, DT.110818444, DT.87066474
NIA Mouse Gene IndexU036447
Consensus CDS ProjectCCDS27684.1
International Mouse Knockout Project StatusTnfrsf13c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 72049 NCBI Gene Model | MGI Sequence Detail 2593 C57BL/6J ±  kb
transcript NM_028075 RefSeq | MGI Sequence Detail 1906 C57BL/6 
polypeptide Q9D8D0 UniProt | EBI | MGI Sequence Detail 175 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022338 Tumour necrosis factor receptor 13C
InterPro IPR015336 Tumour necrosis factor receptor 13C, TALL-1 binding domain
Protein Ontology PR:000001957 tumor necrosis factor receptor superfamily member 13C
Graphical View of Protein Domain Structure
References
(Earliest) J:25731 Miller DJ, et al., Phenotypic and genetic characterization of a unique B lymphocyte deficiency in strain A/WySnJ mice. Eur J Immunol. 1991 May;21(5):1123-30
(Latest) J:212997 Frederico B, et al., BAFF receptor deficiency limits gammaherpesvirus infection. J Virol. 2014 Apr;88(8):3965-75
All references(65)
Other
accession IDs
MGD-MRK-23965, MGI:103101

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory