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Sulf2
Gene Detail
 Symbol
Name
ID
Sulf2
sulfatase 2
MGI:1919293
Synonyms 2010004N24Rik, mKIAA1247
Feature Type protein coding gene
Genetic Map
Chromosome 2
86.31 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:166073089-166155663 bp, - strand
From VEGA annotation of GRCm38

  82575 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10313  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: extracellular sulfatase
Gene Tree: Sulf2

Human
homologs
Human Homolog SULF2, sulfatase 2
NCBI Gene ID 55959
neXtProt AC  NX_Q8IWU5
Human Synonyms  HSULF-2
Human Chr (Location)  20q12-q13.2; chr20:47657406-47786629 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(271) : Gene trapped(266) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene may lead to a partially penetrant, strain-dependent phenotype of embryonic lethality, reduced postnatal body weight, lung abnormalities, brain malformations, and reduced fertility. Mice homozygous for a hypomorphic gene-trap allele display skeletal defects.
 
Phenotype Images(3)
Interactions
Sulf2 interacts with 223 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process bone development, cartilage development, ...
Component cell surface, endoplasmic reticulum, ...
Function alkyl sulfatase activity, arylsulfatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (134)    Tissues (104)    Images (40)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 109
In situ reporter (knock in) 11
RT-PCR 14
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(21) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000001130 (Evidence)
Ensembl Gene ModelENSMUSG00000006800 (Evidence)
Entrez Gene72043 (Evidence)
DFCITC1571976
EC3.1.6.-
Consensus CDS ProjectCCDS17086.1
International Mouse Knockout Project StatusSulf2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001130 VEGA Gene Model | MGI Sequence Detail 82575 C57BL/6J ±  kb
transcript OTTMUST00000002215 VEGA | MGI Sequence Detail 4580 Not Applicable 
polypeptide OTTMUSP00000001078 VEGA | MGI Sequence Detail 875 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(564 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
InterPro IPR017850 Alkaline-phosphatase-like, core domain
InterPro IPR014615 Extracellular sulfatase
InterPro IPR024609 Extracellular sulfatase, C-terminal
InterPro IPR000917 Sulfatase
InterPro IPR024607 Sulfatase, conserved site
Protein Ontology PR:000015817 extracellular sulfatase Sulf-2
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:205898 Maltseva I, et al., The SULFs, extracellular sulfatases for heparan sulfate, promote the migration of corneal epithelial cells during wound repair. PLoS One. 2013;8(8):e69642
All references(61)
Other
accession IDs
MGI:2139186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory